tert-butyl (3aR,5S,6aS)-5-(hydroxymethyl)-hexahydro-1H-cyclopenta[c]pyrrole-2-carboxylate

This is a compound called tert-butyl (3aR, 5S, 6aS) -5- (hydroxymethyl) hexahydro-1H-cyclopento [c] pyrrole-2-carboxylate. According to its name, "tert-butyl" is a substituent of an ester group, which is an alkyl group containing a specific structure. " (3aR, 5S, 6aS) " is a conformational label for the chiral center, indicating the spatial arrangement of specific atoms in the molecule.
"5- (hydroxymethyl) " is shown in the 5th position of the cyclopentopyrrole ring with a hydroxymethyl group, that is, a -CH 2O OH group. " "Hexahydro-1H-cyclopento [c] pyrrole" indicates that the core structure of this compound is a hexahydrated cyclopento-pyrrole ring, and there is a hydrogen atom in the "1H" epicycle at a specific position. "-2-formate" is a formate ester structure at position 2 on the ring, and is connected to tert-butyl to form an ester.
In summary, the structure of this compound consists of a cyclopento-pyrrole ring containing a specific chiral configuration as the core. The ring is connected with hydroxyl methyl at position 5, and the position 2 exists in the form of tert-butyl formate. The parts are connected to each other to form the unique chemical structure of this organic compound.

Tert-butyl (3aR, 5S, 6aS) -5- (hydroxymethyl) hexahydro-1H-cyclopento [c] pyrrole-2-carboxylate has a wide range of uses. In the field of organic synthesis, it is often a key intermediate. It can be converted into a variety of complex and biologically active compounds through ingenious reaction pathways.
In the field of pharmaceutical chemistry, this compound has significant uses. Due to its specific stereochemical structure, it may provide a novel parent nucleus structure for drug development. After modification and optimization, potential drug molecules with high selectivity and strong activity may be obtained for the treatment of various diseases, such as inflammation and tumors.
In the field of materials science, it is also promising. By reacting with other monomers or polymers, materials may be endowed with special properties. Such as improving the biocompatibility and mechanical properties of materials, it shows application potential in biomedical materials, high-performance engineering materials, etc.
In addition, in the total synthesis of natural products, the compound may play an important role in the complete synthesis of complex natural products by fitting the structural fragments of some natural products, thus in-depth study of the biological activity and mechanism of action of natural products.

To prepare tert-butyl (3aR, 5S, 6aS) -5- (hydroxymethyl) hexahydro-1H-cyclopento [c] pyrrole-2-carboxylate, the following ancient method can be carried out.
When the starting material is a cyclopentene derivative with a suitable configuration, it is carefully converted in multiple steps to form its basic skeleton. In the first step, the cyclopentene is reacted with a specific electrophilic reagent under mild and precise temperature control conditions, so that the electrophilic addition of the cyclopentene double bond occurs. This step requires careful control of the reaction solvent, reagent dosage and temperature to obtain the desired regio- and stereoselective products.
Then, the addition product is given an appropriate nucleophilic reagent to make it undergo nucleophilic substitution, and key functional groups are introduced at specific positions. This process requires attention to the activity and reaction time of nucleophilic reagents to prevent side reactions from clumping.
Then, by redox method, the oxidation state of functional groups in the molecule is finely adjusted to construct specific hydroxyl and carboxyl precursors in the target molecule. In this step, an appropriate oxidative reducing agent needs to be selected, and the conditions can be flexibly adjusted according to the reaction process.
Wait for the key functional groups to be in place, and then go through the cyclization reaction. Catalysis with suitable catalysts causes cyclization in the molecule to construct the core structure of cyclopentyl pyrrole. This step requires strict catalyst activity and reaction environment, and needs to create a pure and suitable reaction atmosphere.
Finally, with tert-butyl alcohol and corresponding acylating reagents, under the catalysis of suitable bases, esterification is carried out, tert-butyl ester is introduced at the carboxyl group of the pyrrole ring, and hydroxymethyl is precisely introduced at another key position, so tert-butyl (3aR, 5S, 6aS) -5- (hydroxymethyl) hexahydro-1H-cyclopento [c] pyrrole-2-carboxylate. In each step of the reaction, the product needs to be separated and purified in detail. By recrystallization, column chromatography, etc., to maintain the purity of the product. Following this rigorous method, the synthesis of the target product is expected to be achieved.

This is (3aR, 5S, 6aS) -5- (hydroxymethyl) -hexahydro-1H-cyclopento [c] pyrrole-2-carboxylate tert-butyl ester. Its physical and chemical properties are as follows:
In terms of view, this compound is often in a white to quasi-white solid state, which is caused by its intermolecular forces and crystal structure. Under normal temperature and pressure, it is quite stable, and it may be dangerous in case of hot topics or open flames. Its organic structure contains flammable elements such as hydrocarbons.
Its solubility is also an important property. Slightly soluble in water, although there are hydroxymethyl groups in its molecules that can form hydrogen bonds with water, the tert-butyl ester group has strong hydrophobicity, and the combination of the two causes its water solubility to be poor. However, in common organic solvents such as dichloromethane, chloroform, and tetrahydrofuran, the solubility is still good, because these solvents and the compound molecules can form similar intermolecular forces, following the principle of "similar miscibility".
When it comes to the melting point, it is about a specific temperature range, which is determined by its intermolecular forces and lattice energy. The exact melting point needs to be accurately determined experimentally, which can be one of the important indicators for identifying the compound.
In addition, the chemical properties of this compound are active, in that hydroxymethyl groups can undergo oxidation, esterification and other reactions, while tert-butyl ester groups can undergo hydrolysis under specific conditions to release corresponding carboxylic acids. These properties are widely used in the field of organic synthesis and can be used to construct more complex organic molecular structures.

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