Pyrrolo[3,4-c]pyrrole,benzonitrile deriv.

The main application fields of pyrrolio [3,4-c] pyrrobenzonitrile derivatives are particularly important. This derivative has many outstanding performances in the field of materials science. For example, in optoelectronic materials, it can significantly affect the optical and electrical properties of materials. Because of its unique molecular structure, it can endow materials with excellent light absorption and charge transport properties. It is often regarded as a key material in the preparation of organic Light Emitting Diodes (OLEDs), solar cells and other devices, helping to improve the efficiency and stability of the device.
In the field of biomedicine, it has also emerged. Or because of its structure and bioactive molecules have similarities, it can interact with specific targets in organisms. Therefore, in drug development, it can be used as a lead compound. After structural modification and optimization, it is expected to develop innovative drugs for the treatment of specific diseases, such as drug creation for certain cancers and inflammatory diseases.
In the field of chemical synthesis, it can be used as a key intermediate to construct more complex organic molecular structures. Through various reactions in organic synthesis chemistry, such as nucleophilic substitution, cyclization, etc., a series of compounds with specific functions and structures have been derived, which greatly expands the boundaries of organic synthesis chemistry and provides rich possibilities for the creation of new compounds.

To prepare benzonitrile derivatives of pyrrole [3,4-c] pyrrole, there are three methods. First, the nitrogen-containing heterocyclic ring and benzonitrile derivatives are used as raw materials and prepared by condensation reaction. First, take an appropriate amount of nitrogen-containing heterocyclic ring, put it in the reactor, fill it with an inert gas, and remove the air in the kettle. Then add benzonitrile derivatives, accompanied by suitable catalysts, such as organic bases or metal salts. The temperature is controlled within a certain range, usually 50 to 150 degrees Celsius, and the reaction is completed. After the reaction, the product is purified by extraction and column chromatography.
Second, it is formed by cyclization. Select an appropriate bifunctional compound, one end is a nitrile group, and the other end contains an active group that can form a pyrrole ring. In an organic solvent, add a catalyst, such as Lewis acid or protonic acid. Heat to 80 to 180 degrees Celsius to promote its cyclization. During the reaction process, observe it by thin-layer chromatography. After the reaction is completed, cool, crystallize, filter, and obtain a purified product.
Third, by transition metal catalysis. Halogenated benzonitrile and nitrogen-containing heterocycles are used as starting materials, and transition metals such as palladium and copper are selected as catalysts, and the ligands cooperate. In the presence of a base, react in an organic solvent. The temperature is controlled at 60 to 120 degrees Celsius, and the metal catalytic coupling and cyclization steps are taken to form the target product. After the reaction, the impurities were removed by extraction, distillation and other methods to obtain the benzonitrile derivative of pyrrole [3,4-c] pyrrole. Each method has its own advantages and disadvantages, and the actual operation needs to be selected according to the requirements of raw materials, equipment and products.

The chemical properties of pyrrole [3,4-c] pyrrole and benzonitrile derivatives have their own color, state, and taste, and have the characteristics of melting point, boiling point, and solubility. Its color may be bright or dull, and the state may be different from solid, liquid, and gas. Taste or pungent, or tasteless, varies depending on the structure.
The melting point is related to the intermolecular force, and the melting point is higher if the force is strong. Intermolecular hydrogen bonds and the strength of van der Waals forces all affect the melting point. The boiling point is the same. If the molecular weight is large and the force is strong, the boiling point is high.
The solubility is related to the polarity of the molecule, and it is similar to miscibility. If the polarity of the derivative is strong, it is easily soluble in polar solvents, such as alcohols; if the polarity is weak, it is easily soluble in non-polar solvents, such as hydrocarbons.
In addition, its chemical activity is also an important physical property. Because it contains pyrrole-pyrrole and benzonitrile structures, it has specific reactivity. The nitrogen atom of the pyrrole ring is rich in electrons and can participate in electrophilic substitution reactions; the cyanide group of benzonitrile can be hydrolyzed and added, showing a variety of chemical reactivity, and is widely used in organic synthesis. These are all pyrrole [3,4-c] pyrrole and benzonitrile derivatives.

I don't know what you mean by "Pyrrolo [3,4 - c] pyrrole, benzonitrile deriv." What is the price range in the market. This is a very professional and specific chemical, and its price is determined by many factors.
First, the purity has a great impact. If the purity is extremely high, it is almost flawless, and it is suitable for high-end scientific research experiments, the price will be high; if the purity is slightly lower, it will be used for general industrial use, and the price will drop slightly.
Second, the output is also the key. If the output of this product is rare, it needs exquisite and complex processes to produce it, just like a rare treasure, and its price will be high; if it can be mass-produced, the price may be affordable under cost sharing.
Third, the amount of market demand is related to the price. If many industries urgently need this product, the demand is greater than the supply, and the price is bound to rise; if the demand is small, the supply exceeds the demand, and the merchant may reduce the price in order to sell it.
Fourth, the price varies depending on the manufacturer. Well-known large factories, exquisite craftsmanship, high quality, or higher prices; small factories produce, although the price may be low, the quality may be different.
I have not checked the market conditions in detail, so it is difficult to determine the price range. You can go to the chemical product trading platform, consult chemical raw material suppliers or related industry people to get the exact price range.

There are many manufacturers of pyrrole [3,4-c] pyrrole and benzonitrile derivatives in ancient and modern times. In today's world, many chemical and chemical companies are involved in the production of such compounds. Foreign countries such as BASF in Germany have strong scientific research strength, advanced production technology, and have a long-standing reputation in the manufacturing of organic compounds, or involve the production of pyrrole [3,4-c] pyrrole and benzonitrile derivatives. DuPont in the United States is also known for its innovative and high-quality products, and is involved in the production of such derivatives.
There are also many such manufacturers in China. For example, Zhejiang Longsheng, as a giant in the global dye industry, has been deeply cultivated in the field of fine chemicals for many years and has accumulated deep technology. It may have a production layout for fine chemicals such as pyrrole [3,4-c] pyrrole and benzonitrile derivatives. There is also Jiangsu Yangnong Chemical, which focuses on the research and development and production of pesticides and fine chemical products. With its professional technical team and sophisticated production equipment, it may also be involved in the manufacture of such derivatives.
Looking back in the past, although the technology was not as developed as it is today, there were also skilled craftsmen who explored the preparation of related compounds under limited conditions. Ancient alchemists, although their purpose was mostly to seek longevity and to refine alchemy, during their long practice, they had some understanding and records of the reactions of various substances, or were indirectly involved in the synthesis and exploration of similar compounds, but the cognition and technical means at that time were far less systematic and accurate than those of modern times.