N-(2-hydroxyethyl)pyrrole

N- (2 -hydroxyethyl) pyrrole has a wide range of uses and is useful in various fields.
In the field of organic synthesis, it often acts as a key intermediate. Due to its unique chemical structure, it has an active reaction check point. It can be used through various chemical reactions, such as nucleophilic substitution and addition, to build a diverse and complex organic molecular structure. In this way, the synthesis and preparation of many drugs, natural products and functional materials rely on it.
In the process of pharmaceutical research and development, this compound also plays an important role. Due to its specific biological activity, it can act on specific targets in the body, and then exhibit pharmacological effects such as antibacterial, anti-inflammatory, and anti-tumor effects. Researchers often use it as a starting material, and through structural modification and optimization, they hope to obtain new drugs with better efficacy and fewer side effects.
In the field of materials science, N - (2-hydroxyethyl) pyrrole also plays an important role. It can participate in the synthesis of polymer materials and endow materials with unique properties, such as improving material solubility, flexibility, and biocompatibility. In the fields of biomedical materials, coatings, adhesives, etc., this property has contributed greatly to the improvement of material performance and functional expansion.
In addition, in the field of catalysis, it may be a ligand that complexes with metal ions to form a catalyst, showing unique catalytic activity and selectivity, which plays a role in the catalytic process of organic reactions and promotes the efficient progress of the reaction.
In short, N - (2-hydroxyethyl) pyrrole plays an indispensable role in many fields such as organic synthesis, medicine, materials and catalysis due to its own structure and properties, promoting the development and progress of various fields.

N- (2-hydroxyethyl) pyrrole is one of the organic compounds. Its physical properties are particularly important and are related to many chemical and industrial applications.
First of all, under normal temperature and pressure, N- (2-hydroxyethyl) pyrrole is mostly colorless to light yellow liquid. The view is clear, and its fluidity can be seen. It is like a smart water, but its properties are not comparable to water.
Second and boiling point, the boiling point of this substance is quite high, about 200 degrees Celsius. This high temperature can cause it to transform from a liquid state to a gaseous state, and therefore its characteristics. In ordinary environments, it exists in a liquid state, stable and not impatient. < Br >
In addition, the melting point is relatively low, and it is often in the negative range. Under normal low temperature conditions, it is also difficult to condense into a solid state and can still maintain a flowing state.
Its density is slightly larger than that of water. If it is co-placed with water, it can be seen that it sinks underwater, like a pearl falling into the abyss.
Solubility is also an important property. N- (2-hydroxyethyl) pyrrole is soluble in many organic solvents, such as ethanol, ether, etc., just like fish get water, and it is insoluble. It also has a certain solubility in water, which makes it unique in chemical reactions and material separation processes.
In addition, its odor also has characteristics, with a weak special smell, not pungent, but it can also distinguish its unique smell, and the smell can know its properties.
In summary, the physical properties of N- (2-hydroxyethyl) pyrrole, such as properties, boiling point, melting point, density, solubility and odor, are intertwined to constitute its unique physical properties, which are of great significance in the research and application of chemistry.

N- (2-hydroxyethyl) pyrrole is one of the organic compounds. It has unique chemical properties and is worth exploring.
This compound contains a pyrrole ring, which is connected with 2-hydroxyethyl. The pyrrole ring is aromatic, but it is slightly different from the typical benzene aromatic hydrocarbons. The nitrogen atom on its ring has a pair of unshared electron pairs, which participate in the conjugation system, so that pyrrole has a certain electron cloud density distribution characteristic. This property affects its reactivity, making it more active than benzene in the electrophilic substitution reaction, and the substitution check point is also regular. < Br >
The 2-hydroxyethyl group attached to it introduces hydroxyl groups into the molecule. The hydroxyl group is hydrophilic, so N - (2-hydroxyethyl) pyrrole has a certain water solubility. At the same time, the hydroxyl group can participate in a variety of chemical reactions, such as esterification reaction, and can form ester compounds with carboxylic acids under appropriate conditions. And because of the presence of hydroxyl groups, dehydration reactions can occur, or coordination bonds with metal ions can be formed.
In terms of acidity and alkalinity, although the nitrogen atom of the pyrrole ring does not share an electron pair, its basicity is weak due to its participation in conjugation. The hydroxyl group can weakly ionize hydrogen ions, so the whole compound has both weak acidity and alkalinity, and can exhibit different chemical behaviors in different acid-base environments.
In the field of organic synthesis, N- (2-hydroxyethyl) pyrrole can be used as a key intermediate. With its pyrrole ring and hydroxyl properties, it can construct complex organic molecular structures through various reactions, which has potential application value in many fields such as pharmaceutical chemistry and materials science.

The method of making N- (2-hydroxyethyl) pyrrole has been explored by many chemists in the past. One method is also to use pyrrole and ethylene oxide as the starting materials. At the right temperature and the presence of a catalyst, the two are combined. Pyrrole is nucleophilic, and the ring of ethylene oxide is easily broken. The nitrogen atom of pyrrole nucleophilically attacks the carbon atom of ethylene oxide, causing the ring to open, resulting in N- (2-hydroxyethyl) pyrrole. This reaction condition needs to be carefully controlled. If the temperature is too high or too low, it can affect the yield and purity.
There are also 2-chloroethanol and pyrrole as materials. Under the catalysis of the base, the nitrogen atom of pyrrole reacts with the carbon attached to the chlorine atom of 2-chloroethanol, and the chlorine leaves to form N- (2-hydroxyethyl) pyrrole. The type and dosage of bases have a great influence on the reaction process. If the strong alkalinity is too strong, it may cause side reactions to produce and reduce the amount of product.
There are also pyrrole and glycolate as raw materials. After a series of reactions such as transesterification and reduction, the target product can be obtained. First, pyrrole and glycolate are transesterified under the action of the catalyst, and then through the reduction step, the ester group is converted to hydroxyethyl group to obtain N- (2-hydroxyethyl) pyrrole. The reaction steps of this path are slightly complicated, but the reaction selectivity of each step is better, and the product separation and purification are easier.
All synthesis methods have their own advantages and disadvantages. In practical application, when the availability of raw materials, cost, product purity requirements and other factors, choose carefully.

I searched all over the market, but I couldn't find the exact price of N - (2-hydroxyethyl) pyrrole. This is a rather specific chemical, which can be found in unusual markets.
Or in a special chemical raw material market, ask all the merchants, but the price also varies according to time, place, quality and quantity. It has been heard in the past that the price may fluctuate between tens and hundreds of gold per kilogram. If the purchase quantity is very large, the merchant may make a profit, and the price may drop slightly; if the quality and purity are sought, the price will also rise.
Also interviewed in various chemical shops, the fluctuation of their prices is due to the abundance of raw materials, the difficulty of production methods, and the amount of supply and demand. In recent times, if raw materials are abundant, production methods are advanced, and supply exceeds demand, the price will decline; on the contrary, if raw materials are scarce, the system is complicated, and demand exceeds supply, the price will rise.
However, if you want to know the exact price of chemical raw materials, you still need to go to the market of chemical raw materials in person, negotiate with various merchants, and inquire in detail about the relationship between quality, quantity and price before you can get a definite number.