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N- (2- (diethylamino) ethyl) -5- ((z) - (5-fluoro-1, 2-dihydro-2-oxo-3h-indol-3-ylidene) methyl) -2, what is the chemical structure of 4-dimethyl-1h-pyrrole-3-carboxamide
This is about the chemical structure of the compound "N- (2- (diethylamino) ethyl) -5- ((Z) - (5-fluoro-1,2-dihydro-2-oxo-3H-indole-3-subunit) methyl) -2,4-dimethyl-1H-pyrrole-3-formamide".
The structure of this compound is based on the pyrrole ring. In the 3-position of the pyrrole ring, there is a formamide group. There are no other substituents on the nitrogen atom in this formamide group, but only the pyrrole ring, while the carbonyl group is connected to the methyl group. The 2,4-position has methyl substitution, respectively, which changes the electron cloud distribution and spatial steric resistance of the pyrrole ring. The 5-position is connected to an indolone structure through methylene, and this connection is in the (Z) configuration, that is, the larger groups on both sides of the double bond are on the same side. The indolone structure is dihydro at the 1,2-position, carbonyl oxygen at the 2-position, and fluorine atom at the 5-position, which endows the indolone structure with specific electronic properties. In addition, through the methylene-linked pyrrole ring, its nitrogen atom is connected to 2- (diethylamino) ethyl, which is a nitrogen-containing aliphatic chain substituent, which can increase the hydrophilicity of the compound and the possibility of interacting with biological macromolecules.
Such a structure makes the compound have unique physical, chemical and biological activities, or have important value in drug research and development, organic synthesis and other fields.
N- (2- (diethylamino) ethyl) -5- ((z) - (5-fluoro-1, 2-dihydro-2-oxo-3h-indol-3-ylidene) methyl) -2, what are the physical properties of 4-dimethyl-1h-pyrrole-3-carboxamide
This is an organic compound with a long and complicated name. The physical properties of this compound are related to its appearance, melting point, boiling point, solubility and density.
Looking at its appearance, it is often presented in solid form, but the specific color state may vary depending on the purity and crystal form, or it is white crystalline, or it is powdery with a little color.
As for the melting point, the melting point of an organic compound is determined by intermolecular forces and structural regularity. This compound has a complex structure, contains a variety of functional groups, and is rich in intermolecular forces, resulting in a high melting point. However, the exact value needs to be accurately determined by experiments.
The boiling point is also closely related to the molecular structure. Due to the large size of the molecule and the large number of functional groups, the intermolecular force is strong, and more energy is required to boil it, so the boiling point may be quite high.
Solubility is related to its dissolution in various solvents. In view of the fact that there are polar functional groups in the molecule, such as carboxyamide groups, in polar solvents, such as water and alcohols, there may be some solubility; however, the molecule also contains non-polar parts, such as dihydroindolyl, in non-polar solvents, such as alkane solvents, solubility or poor.
Density is also related to molecular structure and composition. Due to the type and number of atoms, its density may have a specific range, but the exact value depends on experimental determination. < Br >
The physical properties of this compound are determined by its unique molecular structure, but the exact data still needs to be experimentally investigated to obtain accurate data.
What is the synthesis method of n- (2- (diethylamino) ethyl) -5- ((z) - (5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene) methyl) -2 4-dimethyl-1h-pyrrole-3-carboxamide
To prepare n- (2- (diethylamino) ethyl) -5- ((Z) - (5-fluoro-1,2-dihydro-2-oxo-3H-indole-3-subunit) methyl) -2,4-dimethyl-1H-pyrrole-3-formamide, the following method can be followed.
First take an appropriate amount of 5-fluoro-1,2-dihydro-2-oxo-3H-indole and place it in a clean reaction vessel. In this vessel, add a suitable solvent, such as dichloromethane or N, N-dimethylformamide, to fully dissolve the indole. In this solution, slowly add specific aldehyde compounds dropwise, and at the time of dropwise addition, the reaction temperature needs to be strictly regulated, usually maintained at a low temperature, such as between 0 ° C and 5 ° C. After the dropwise addition, the reaction system is slowly warmed to room temperature, and the reaction is continuously stirred to promote the full progress of the reaction. This step aims to form the key intermediate, that is, the structure containing (Z) - (5-fluoro-1,2-dihydro-2-oxo-3H-indole-3-subunit) methyl.
Then, take another 2,4-dimethyl-1H-pyrrole-3-formyl chloride and add it to the above reaction system. At the same time, an appropriate amount of acid binding agent, such as triethylamine, is added to neutralize the acid generated by the reaction to ensure that the reaction advances in a positive direction. In this reaction stage, the temperature should be controlled in a moderate range, about 20 ° C to 30 ° C, and stirred continuously for several hours to achieve the desired degree of reaction.
In addition, prepare 2 - (diethylamino) ethylamine and slowly add it to the obtained reaction mixture. In this step, the temperature may need to be slightly adjusted, and it can be raised to 40 ° C to 50 ° C, and the stirring state is maintained. When the reaction is completed, the product is purified by conventional separation and purification methods, such as column chromatography or recrystallization. The target product, n - (2 - (diethylamino) ethyl) - 5 - ((Z) - (5 - fluoro - 1,2 - dihydro - 2 - oxo - 3H - indole - 3 - subunit) methyl) - 2,4 - dimethyl - 1H - pyrrole - 3 - formamide, can be obtained by these steps.
N- (2- (diethylamino) ethyl) -5- ((z) - (5-fluoro-1, 2-dihydro-2-oxo-3h-indol-3-ylidene) methyl) -2, what are the application fields of 4-dimethyl-1h-pyrrole-3-carboxamide
This is a complex organic compound with a wide range of application fields. In the field of pharmaceutical research and development, due to its specific chemical structure, or unique biological activity. It may be used as a potential drug lead compound for researchers to further explore its effects on specific disease-related targets, such as some tumor diseases. Because it contains specific functional groups, it may interact with key proteins or enzymes in tumor cells to block key processes such as tumor cell proliferation and migration, bringing new opportunities for the creation of anti-cancer drugs.
In the field of materials science, its unique structure may endow materials with special optical and electrical properties. For example, it is introduced into specific polymer materials or makes materials have fluorescence properties, and it has emerged in the construction of optical sensors. By changing the fluorescence intensity or wavelength in response to specific substances, sensitive detection of harmful substances in the environment or specific biomarkers in organisms can be achieved.
In the field of organic synthetic chemistry, the exploration of the synthesis route of this compound is of great value. Its complex structure prompts chemists to develop novel synthesis methods and strategies, and promotes the progress of organic synthesis technology. The study of reaction conditions and reagent selection during the synthesis process can provide reference for the synthesis of other similar complex compounds, expand the boundaries of organic synthesis chemistry, and help create more functional organic molecules.
N- (2- (diethylamino) ethyl) -5- ((z) - (5-fluoro-1, 2-dihydro-2-oxo-3h-indol-3-ylidene) methyl) -2, what is the market outlook for 4-dimethyl-1h-pyrrole-3-carboxamide
The full name of this compound is longer, and the Chinese name is N- (2- (diethylamino) ethyl) -5 - (Z) - (5-fluoro-1,2-dihydro-2-oxo-3H-indole-3-subunit) methyl) -2,4-dimethyl-1H-pyrrole-3-formamide. However, at present, the market prospect of this substance seems to be hidden in the clouds, and it is still difficult to gain clear insight.
This substance may have potential opportunities in the field of pharmaceutical research and development. In the prevention and treatment of tumor diseases, many pyrrole and indole derivatives with specific structures often exhibit anti-tumor activities. If this compound also has such efficacy, through rigorous and systematic pharmacological research and clinical trials, it may become a new type of anti-cancer drug, which may be a major market opportunity.
However, it also faces many challenges. First, the road of drug development is long and full of thorns, requiring massive investment of manpower, material resources and time. From basic research to clinical application, it must undergo many rigorous tests to prove its safety and effectiveness. Second, the market competition is very fierce. In the field of medicine, anti-cancer drug research and development is a hot direction, and many pharmaceutical companies and scientific research institutions are involved in it. If you want to stand out, it is not easy. Third, after the drug is approved for marketing, marketing activities are also key. It is necessary to overcome many obstacles such as medical insurance policies, doctor recognition, and patient acceptance.
In summary, although N - (2 - (diethylamino) ethyl) -5 - ((Z) - (5 - fluoro-1,2 - dihydro-2 - oxo-3H - indole-3 - subunit) methyl) -2,4 - dimethyl-1H - pyrrole-3 - formamide has potential value in the field of medicine, its market prospect is still in a confusing state due to many factors, and it needs to be continuously explored and developed by scientific research and industry.