Methyl1-methyl-1H-pyrrole-2-carboxylate

Methyl-1-methyl-1H-pyrrole-2-carboxylic acid ester is an important compound in organic chemistry. It has a wide range of uses and is often a key intermediate in the synthesis of drugs. If you want to make a drug molecule with a specific structure, this compound can use its pyrrole ring and ester group activity to combine with other reagents through various chemical reactions, such as nucleophilic substitution, addition, etc., to construct a complex molecular structure with biological activity.
In the field of materials science, it is also quite useful. It can be used as a raw material to prepare polymer materials with special properties. Due to its unique structure, after polymerization, the polymer formed may have unique electrical, optical or mechanical properties, such as photoelectric materials, sensor materials, etc.
In the experimental investigation of organic synthetic chemistry, this compound is also a commonly used reagent. Chemists can use it to participate in various reactions, explore new reaction pathways and methods, and contribute to the development of organic synthesis. Due to the presence of methyl and ester groups on the pyrrole ring, the molecule is endowed with specific electronic effects and steric resistance, which makes the reaction exhibit unique selectivity and activity, enabling chemists to delve deeper into the reaction mechanism and develop novel and efficient synthesis strategies.

The synthesis method of methyl-1-methyl-1H-pyrrole-2-carboxylic acid ester is described in detail by you.
One method can also start from pyrrole. Shilling pyrrole is methylated in a suitable solvent with a methylating agent, such as iodomethane, under the catalysis of a base, to obtain 1-methyl pyrrole. Subsequently, 1-methyl pyrrole is reacted with appropriate acylating reagents, such as oxalyl chloride, methyl chloroformate, etc., under suitable conditions, and a methyl ester group of carboxyl group can be introduced to obtain methyl-1-methyl-1H-pyrrole-2-carboxylate.
Another method is to use a suitable compound containing pyrrole ring as the starting material. If the raw material has a methyl group in the first position of the pyrrole ring, and the second position is a group that can be replaced by a carboxyl methyl ester group, such as a halogen atom or the like. Then it can be carbonylated with carbon monoxide, methanol and suitable catalysts, such as palladium catalysts, at suitable temperature and pressure, and the target product can be directly obtained.
Another way is to construct a pyrrole ring first. Using nitrogenous and carbon-containing small molecule compounds as starting materials, such as 1,4-dicarbonyl compounds and ammonia or amines, under acid catalysis, pyrrole rings are formed by Paal-Knorr synthesis. If methylating reagents are present in the reaction system, or subsequent methylation steps are carried out, methyl groups are introduced at 1 position. Then, through acylation and other steps, the carboxyl methyl ester group is connected at the 2 position, and methyl-1-methyl-1H-pyrrole-2-carboxylic acid ester can also be obtained.
All these methods have their own advantages and disadvantages, which need to be carefully selected according to the availability of raw materials, the difficulty of reaction conditions, and the high or low yield.

Methyl-1-methyl-1H-pyrrole-2-carboxylic acid ester is one of the organic compounds. Its physical properties are quite impressive.
Looking at its appearance, it is often colorless to light yellow liquid, clear and with a specific luster. The smell of this substance is also unique, emitting a faint special smell, but it is not pungent and intolerable, but is still mild.
When it comes to boiling point, under specific pressure conditions, it can reach a certain exact temperature value. This temperature is the key node of its transformation from liquid to gas state, reflecting its volatile characteristics. In terms of melting point, there is also a corresponding definition, which is the temperature limit for the melting of a substance from a solid state to a liquid state.
Furthermore, density is also one of its important physical properties. The density of the substance indicates the amount of mass contained in its unit volume. Compared with other common substances, it has a unique value, which affects its distribution and behavior in various mixed systems.
Solubility cannot be ignored. In common organic solvents, such as ethanol, ether, etc., it exhibits good solubility, and can be miscible with these solvents in a certain proportion to form a uniform solution. However, in water, its solubility is relatively limited, and this property is closely related to structural factors such as molecular polarity.
In addition, the refractive index is also a physical quantity that characterizes its optical properties. By measuring its refractive index, we can know the strength of its ability to refract light, which may have potential application value in related fields such as optical materials. In summary, the various physical properties of methyl-1-methyl-1H-pyrrole-2-carboxylate together build its unique material properties and lay the foundation for its research and application in many fields such as chemistry and materials science.

Methyl-1-methyl-1H-pyrrole-2-carboxylic acid ester, this is an organic compound. It has unique chemical properties.
Looking at its structure, it contains a pyrrole ring, and has a methyl substitution at 1 position and a carboxylic acid methyl ester group at 2 positions. Due to the presence of these groups, it exhibits a variety of chemical activities.
In terms of physical properties, it is usually a liquid or a solid state, depending on the specific ambient temperature and pressure. Its solubility also has characteristics. It often has good solubility in organic solvents such as ethanol and ether, but poor solubility in water. This is due to the lipophilicity of the molecular structure.
When it comes to chemical properties, first of all, due to the presence of pyrrole rings, it has aromaticity. This aromaticity makes the molecule stable to a certain extent, but it also allows it to undergo electrophilic substitution reactions. For example, under appropriate conditions, it can react with halogenated reagents to introduce halogen atoms on the pyrrole ring. Secondly, its carboxylic acid methyl ester group can undergo hydrolysis reaction. Under acidic or basic conditions, the ester group breaks to form carboxylic acid and methanol, respectively. Hydrolysis is more complete under alkaline conditions, because the resulting carboxylic acid can further react with the base to form a salt. Furthermore, the methyl group in the compound connected to the pyrrole ring can undergo a substitution reaction under appropriate reagents and conditions. For example, under the action of strong bases with halogenated hydrocarbons, the hydrogen atom on the methyl group can be replaced by other groups.
In summary, methyl-1-methyl-1H-pyrrole-2-carboxylic acid esters have many chemical properties such as electrophilic substitution, hydrolysis, and methyl substitution due to their special structure, and have important applications in the field of organic synthesis.

The price in Guanfu's market often changes due to various reasons, and it is difficult to determine the price of "methyl-1-methyl-1H-pyrrole-2-carboxylate". This is a fine chemical, and its price is affected by many factors.
First, the situation of supply and demand is the main reason for the price. If there are many people in need, and the demand exceeds the supply, the price will rise; if the supply exceeds the demand, the stock of goods will be in the market, and the price will drop.
Both, the manufacturing cost is also the key. The price of raw materials, the method of manufacturing, and the level of energy consumption are all related to the cost. If the raw materials are rare and the manufacturing is complicated, the cost will be high, and the price will follow.
The three are divided into quality, and the price is different. Those with high quality, the price is always high; those with lower prices are low.
Furthermore, the competition in the market also has an impact. Businesses compete for profits, and the price may be lower; those with a single market can have their own price.
In addition, policies and regulations, exchange rate changes, etc., can also change the price.
To know the exact price, ask chemical raw material suppliers, chemical trading platforms, or check recent market reports to get an accurate number. Based on the current situation, it is difficult to know the price.