Methyl 4-bromopyrrole-2-carboxylate

Methyl-4-bromopyrrole-2-carboxylate is an important compound in organic chemistry. It has a wide range of uses and is often a key intermediate in the synthesis of many drugs in the field of medicinal chemistry. The structure of the Gein pyrrole ring has a unique biological activity and can interact with specific targets in organisms. The introduction of bromine atoms and carboxyl methyl esters can further adjust the physicochemical properties and biological activities of the compounds, thus assisting in the development of drugs with specific therapeutic effects.
In the field of materials science, it also has its uses. For example, it can be introduced into polymer materials by chemical reactions to give novel photoelectric properties to the materials. Due to its conjugated system and specific functional groups in the structure, it may improve the absorption and emission efficiency of materials to light, and show potential application value in the fields of organic Light Emitting Diode (OLED) and solar cells.
Furthermore, in organic synthetic chemistry, as a key synthetic block, it can construct more complex organic molecular structures through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., providing important raw materials for organic synthetic chemists to explore new compounds and new reaction paths. In short, methyl-4-bromopyrrole-2-carboxylic acid esters play an indispensable role in many fields due to their unique structure, promoting the continuous development and progress of related science and technology.

The synthesis of fuchmethyl-4-bromo-pyrrole-2-carboxylic acid esters has been studied throughout the ages. Common ones have the following approaches.
First, pyrrole is used as the starting material. Under suitable reaction conditions, pyrrole is first brominated with brominating reagents such as bromine or N-bromosuccinimide (NBS). This reaction requires careful control of reaction temperature, time and reagent dosage to prevent over-bromination. After 4-bromo-pyrrole is obtained, it is reacted with carboxylic acid esterification reagents such as methyl chloroformate in an alkali-catalyzed environment. The alkali can be selected from potassium carbonate, sodium carbonate, etc., and the reaction is carried out in organic solvents such as dichloromethane and tetrahydrofuran. After the nucleophilic substitution reaction, the final methyl-4-bromo pyrrole-2-carboxylate is obtained.
Second, start from 2-pyrrolitic acid. First, 2-pyrrolitic acid is converted into the corresponding acyl chloride, and commonly used chlorination reagents such as dichlorosulfoxide and phosphorus trichloride. After the acyl chloride is formed, it is esterified with methanol to obtain methyl 2-pyrrolide. Subsequently, it is brominated, and the bromination step is the same as the previous method to obtain the target product.
Third, it is synthesized by one-pot method. The raw materials such as pyrrole, brominating reagent, carboxylic acid esterification reagent and alkali are synthesized in one step in the same reaction system by carefully adjusting the reaction conditions, such as temperature, pH, reagent addition sequence, etc. Although this method can simplify the operation process, it is more stringent to control the reaction conditions.
The above synthesis methods have their own advantages and disadvantages. Those who want to synthesize this product should weigh the choice according to specific needs, availability of raw materials and convenience of reaction conditions.

Methyl-4-bromopyrrole-2-carboxylic acid ester, this is an organic compound. Its physical properties are quite critical, and it is related to many chemical processes and practical applications.
Looking at its properties, under normal temperature and pressure, it is mostly in a solid state, but the specific form will also change depending on the purity and preparation method. Its color is often white to light yellow powder or crystalline, which is convenient for preliminary identification and distinction.
Melting point is also an important physical property. After experimental determination, its melting point is roughly within a certain range, which is of great significance for the determination of the purity of the compound. The higher the purity, the narrower the melting point range and the closer to the theoretical value.
In terms of solubility, methyl-4-bromopyrrole-2-carboxylate exhibits good solubility in common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). This property is extremely critical in organic synthesis reactions because it needs to be carried out in a solution environment. A suitable solvent can promote full contact of the reactants and speed up the reaction rate. However, in water, its solubility is poor, mainly due to the molecular structure of the compound, which is relatively weak in polarity and has little interaction with water molecules.
In addition, the density of the compound also has specific values. Although it is not often mentioned as melting point and solubility, density data is indispensable in some chemical operations involving accurate measurement and phase equilibrium. It helps to determine the content and distribution of substances in different phases.
In short, these physical properties of methyl-4-bromopyrrole-2-carboxylic acid esters play an important role in many fields such as organic synthesis and drug development, providing a foundation for in-depth exploration of their chemical properties and applications.

Methyl-4-bromo pyrrole-2-carboxylate, this is one of the organic compounds. Its chemical properties are unique and valuable for investigation.
Looking at its structure, it contains a pyrrole ring, which is a five-membered nitrogen-containing heterocyclic ring and has aromatic properties, which makes the compound stable to a certain extent. The 4-position bromine atom on the ring, the bromine atom is an electron-absorbing group, which can affect the electron cloud distribution of the pyrrole ring and reduce the electron cloud density on the ring. This not only affects its electrophilic substitution activity, but also the bromine atom itself can participate in reactions such as nucleophilic substitution. Under appropriate conditions, the bromine atom is easily attacked by nucleophilic reagents, resulting in substitution and generation of new derivatives.
In addition, the 2-position carboxylic acid methyl ester group, which is also an electron-withdrawing group, will further change the electron cloud density of the pyrrole ring and affect the reactivity of the whole molecule. The ester group can undergo hydrolysis, and under acidic or basic conditions, the corresponding carboxylic acid or carboxylate is hydrolyzed. In basic hydrolysis, ester bonds are broken to form carboxylic salts and alcohols; in acidic hydrolysis, carboxylic acids and alcohols are formed.
In addition, due to the presence of multiple activity check points, the compound can participate in a variety of organic synthesis reactions, such as condensation reactions with active hydrogen-containing compounds to construct more complex organic structures, which has potential applications in pharmaceutical chemistry, materials science and other fields. Due to the synergy of these functional groups in their structure, their chemical properties are rich and diverse, making them an important research object in organic synthetic chemistry.

The price range of methyl-4-bromo-pyrrole-2-carboxylic acid ester on the market is difficult to determine. There are three reasons for this: First, the application field of this substance is diverse, and it is involved in many aspects such as medicinal chemistry and organic synthesis. Different uses have different requirements for purity, and the price varies. For medical use, it needs extremely high purity and the price is high; while it is only for general organic synthesis experiments, the purity requirements are slightly lower, and the price is slightly cheaper. Second, the preparation process is simple and poor. If the process is complicated, it involves multi-step reactions, special reagents and conditions, and the cost increases, and the price also follows. Three market supply and demand relationships determine its price. If there are many applicants and few suppliers, the price will rise; on the contrary, if the supply is sufficient and the demand is flat, the price will tend to fall.
Looking at the past market conditions, the price of methyl-4-bromopyrrole-2-carboxylate fluctuates quite a lot. For those with a purity of about 95%, the price per gram may range from tens of yuan to 100 yuan. However, if the purity is above 98%, especially suitable for pharmaceutical developers, the price per gram may exceed 100 yuan, or even higher. When purchasing in bulk, there are also different discounts due to the amount, and the unit price can be reduced if the quantity is large. < Br >
To determine the exact price range, you can consult the chemical supplier for details, or refer to the quotation of a well-known chemical trading platform, so that you can obtain an accurate price.