Ethyl 5-methyl-1H-pyrrole-2-carboxylate

Ethyl + 5 - methyl - 1H - pyrrole - 2 - carboxylate is 5 - methyl - 1H - pyrrole - 2 - carboxylate, and its chemical structure is as follows.
The core structure of this compound is a pyrrole ring, which is a five-membered heterocyclic ring containing a nitrogen atom and is aromatic. In the 1H - pyrrole structure, the hydrogen atom is attached to the nitrogen atom. In ethyl 5-methyl-1H-pyrrole-2-carboxylic acid, the pyrrole ring at position 2 is connected to a carboxylic acid ethyl ester group (- COOCH ³ CH < unk >). In this group, the carbonyl group (C = O) is connected to the oxygen atom, and the oxygen atom is connected to the ethyl group (- CH < unk > CH < unk >).
From the overall structure, 5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester contains different groups such as pyrrole ring, ester group and methyl group, and each group has unique chemical properties, which makes the compound exhibit various chemical activities. The ester group can undergo hydrolysis, alcoholysis and other reactions, and the hydrogen atom on the pyrrole ring can be substituted under certain conditions, while the methyl group can participate in some reactions involving alkyl groups. Such structural characteristics make 5-methyl-1H-pyrrole-2-carboxylic acid ethyl ester have potential application value in organic synthesis, medicinal chemistry and other fields.

Ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ester, which is widely used. In the field of medicine, it is often a key intermediate, helping to create a variety of drugs. For example, in the preparation of some antidepressant drugs, with its unique chemical structure, it can participate in the construction of the core pharmacoactive group, which is transformed through a series of reactions, giving the drug the ability to precisely act on the target, helping it to adjust the balance of neurotransmitters and relieve depression symptoms.
In the field of materials science, it also has good performance. It can be used as a starting material for the synthesis of special functional materials. After clever chemical modification and polymerization, materials with unique optical and electrical properties can be prepared. For example, when preparing organic optoelectronic materials, their structures can optimize the charge transport and luminescence properties of materials, and are expected to be applied to cutting-edge fields such as organic Light Emitting Diodes (OLEDs) to improve display effects and device performance.
In the field of organic synthetic chemistry, it is an important cornerstone. As organic compounds with high activity, they can react with a variety of reagents through many classical organic reactions, such as nucleophilic substitution, electrophilic addition, etc., to derive organic compounds with rich structures, providing diverse possibilities for the development of organic synthetic chemistry and promoting the construction and innovation of complex organic molecules.

To prepare Ethyl 5 - methyl - 1H - pyrrole - 2 - carboxylate, the following ancient method can be used.
First take appropriate starting materials, preferably 2 - methyl pyrrole and diethyl oxalate. Place 2 - methyl pyrrole in a reactor and empty the air in the kettle with an inert gas such as nitrogen to prevent oxidation. Then slowly add diethyl oxalate, and the molar ratio of the two should be carefully prepared, about 1:1.2 to 1:1.5. This ratio can make the reaction sufficient and reduce side reactions.
Add an appropriate amount of base as a catalyst, such as sodium ethanol, in an amount of about 0.1 to 0.2 times the number of moles of 2 - methyl pyrrole. The alkali can promote the reaction and accelerate the transfer of ester groups.
Then, the reaction system is heated to 120-140 ° C, and the temperature is maintained and stirred continuously. Under this temperature and stirring conditions, the molecules interact and nucleophilic substitution occurs. The ethyl ester group of diethyl oxalate gradually replaces the hydrogen atom on 2-methyl pyrrole to form Ethyl 5-methyl-1H-pyrrole-2-carboxylate.
During the reaction, the reaction progress needs to be monitored regularly by thin-layer chromatography (TLC) or other suitable analytical methods. When the raw material point almost disappears and the product point is obvious and stable, the reaction can be regarded as basically completed.
After the reaction is completed, the system is cooled to room temperature. Carefully adjust the pH to a weakly acidic pH of about 5-6 with a dilute acid such as dilute hydrochloric acid. This can convert the excess base into a salt for subsequent separation.
Next, an organic solvent such as ethyl acetate is extracted, and multiple extractions are made to fully extract the product. The organic phases are combined and dried with anhydrous sodium sulfate to remove the moisture.
Finally, the organic solvent is evaporated by reduced pressure distillation and the fractions in a specific boiling point range are collected to obtain Ethyl 5-methyl-1H-pyrrole-2-carboxylate product. After this series of operations, a relatively pure target product can be obtained.

Ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ester, which is colorless to light yellow liquid, has a special odor, and has a slight irritation in smell. Its boiling point is about 118-120 ° C (2.0 kPa), and the material gradually changes from liquid to gaseous at this temperature. The relative density (water = 1) is about 1.08-1.10, which is slightly heavier than water and can slowly settle in water.
In terms of solubility, it is slightly soluble in water, but easily soluble in organic solvents such as ethanol, ether, and chloroform. It can be miscible with organic solvents in a certain proportion to form a uniform and stable solution.
In terms of chemical stability, under normal environmental conditions, the properties of ethyl-5-methyl-1H-pyrrole-2-carboxylic acid ester are relatively stable. However, in case of open flame or hot topic, it is easy to cause combustion. Because of its flammability, it may produce irritating fumes when burning. In addition, it can also react violently with strong oxidants, resulting in dangerous situations. Therefore, when storing and using, special attention should be paid to keep away from fire sources, heat sources and strong oxidants, and store them properly to ensure safety.

"Tiangong Kaiwu" records the principle of all things in ancient Chinese, and today describes the market prospect of "Ethyl 5 - methyl - 1H - pyrrole - 2 - carboxylate" in its style.
"Ethyl 5 - methyl - 1H - pyrrole - 2 - carboxylate", the Chinese name may be ethyl 5 - methyl - 1H - pyrrole - 2 - carboxylate. This substance has emerged in the chemical industry and the prospect is beginning to emerge.
Looking at the present, the industry of organic synthesis is booming, and the demand for fine chemicals is on the rise. Due to its unique chemical structure, this compound has potential uses in drug research and development, material synthesis, etc. In drug research and development, it can be a lead compound, which can be cleverly modified, or become a specific drug to cure diseases. Therefore, pharmaceutical manufacturers are paying more and more attention to it.
The way of material synthesis may add to the construction of new materials. Such as photoelectric materials, if this compound is incorporated, or the material is endowed with specific photoelectric properties, it is suitable for high-end display and energy storage, attracting the attention of the materials industry.
However, its market also has challenges. The complex synthesis process, the cost remains high, and the scale of production is limited. And the competition among similar substitutes is fierce. If you want to occupy the top of the market, you need to improve the process, reduce costs and increase efficiency.
But overall, with the advance of science and technology and the deepening of research and development, if the bottleneck can be broken, "Ethyl 5 - methyl - 1H - pyrrole - 2 - carboxylate" may shine in the future market, adding splendor to the chemical industry.