Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate

Ethyl 5 - formyl - 2,4 - dimethyl - 1H - pyrrole - 3 - carboxylate, this is the name of an organic compound. From its name, its chemical structure can be deduced. "Ethyl", ethyl is also, is a common organic group, represented by -C ² H. "5 - formyl", that is, there is a formyl group (-CHO) at position 5 of the pyrrole ring. "2,4 - dimethyl" refers to the presence of a methyl group (-CH 🥰) at positions 2 and 4 of the pyrrole ring. " 1H-pyrrole "indicates that this is a pyrrole ring, a five-membered heterocyclic ring containing a nitrogen atom." 3-carboxylate "means that there is a carboxylic acid ethyl ester group (-COOCH -2 CH) attached to the pyrrole ring at position 3. The chemical structure of this compound is a pyrrole ring as the core, with a methyl group at positions 2 and 4, a carboxylic acid ethyl group at position 3, and a formyl group at position 5. In the diagram, the nitrogen atom in the pyrrole ring occupies one place, and the remaining four positions are connected to the corresponding groups according to the above description. This structure gives the compound unique chemical properties and may have important uses in the field of organic synthesis.

Ethyl 5 - formyl - 2,4 - dimethyl - 1H - pyrrole - 3 - carboxylate, the Chinese name can be called 5 - formyl - 2,4 - dimethyl - 1H - pyrrole - 3 - carboxylate ethyl ester. This substance has a wide range of uses and is mostly used as a key intermediate in organic synthesis in the field of medicine and chemical industry.
First, in drug creation, based on this, a heterocyclic system with diverse structures can be built to obtain compounds with specific biological activities. For example, by a specific chemical reaction, it is connected to a nitrogen-containing and oxygen-containing heterocyclic fragment, and the new compound may have antibacterial, anti-inflammatory, anti-tumor and other activities, providing the possibility for the development of new drugs.
Second, in the field of materials science, it can participate in the preparation of functional materials. Because its molecular structure contains active groups such as pyrrole ring and ester group and formyl group, it can be polymerized and copolymerized with other monomers, and the unique photoelectric properties of the material are provided. It is used in the manufacture of organic Light Emitting Diodes, solar cells and other photoelectric devices.
Third, it also has important uses in dye chemistry. By modifying its structure, chromophore groups can be introduced to adjust the molecular conjugate system, and a series of dyes with bright color and excellent performance can be synthesized for textile, printing and dyeing industries.
In short, Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate has key application value in many fields due to its unique molecular structure. With the progress of scientific research, its use may be more extensive.

Ethyl 5 - formyl - 2,4 - dimethyl - 1H - pyrrole - 3 - carboxylate, that is, 5 - formyl - 2,4 - dimethyl - 1H - pyrrole - 3 - carboxylate, is synthesized as follows:
##Take 2,4 - dimethylpyrrole as the starting material
1. ** Formalylation reaction **:
- Vilsmeier - Haack reaction can be used. Mix 2,4 - dimethylpyrrole with N, N - dimethylformamide (DMF) and phosphorus oxychloride (POCl 🥰). At low temperatures, such as 0-5 ° C, POCl is slowly added dropwise to the DMF-containing reaction system to generate an active Vilsmeier reagent. After that, 2,4-dimethylpyrrole is added, and the reaction is gradually warmed to room temperature or moderately heated for several hours. This reaction can introduce formyl groups at the 5-position of the pyrrole ring to give 5-formyl-2,4-dimethylpyrrole.
- The reaction mechanism is that POCl reacts with DMF to form an electrophilic Vilsmeier reagent, which attacks the 5-position with a high electron cloud density of the pyrrole ring, and then hydrolyzes to obtain formylated products.
2. ** Esterification reaction **:
- Using 5-formyl-2,4-dimethyl pyrrole and ethanol as raw materials, the reaction is carried out in the presence of acidic catalysts such as concentrated sulfuric acid or p-toluenesulfonic acid. After mixing the reactants, heat and reflux for several hours. Catalysts such as concentrated sulfuric acid can promote the esterification reaction of carboxylic acid and alcohol to generate 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester.
- During the reaction, the acid catalyst protonates the carboxyl group, enhances its electrophilicity, and facilitates the attack of the alcohol hydroxyl group. After a series of intermediate conversions, ester bonds are finally formed.
###Using ethyl acetoacetate derivatives as raw materials
1. ** Construction of pyrrole rings **:
- Using the activity of alpha-hydrogen of ethyl acetoacetate, the synthesis of Paal-Knorr occurs with a suitable ammonia source (such as a derivative of urea or ammonia) and another carbonyl compound with a suitable substituent (such as 2-butanone) catalyzed by acid or base. In acid catalysis, p-toluenesulfonic acid and the like are usually used, and in alkali catalysis, sodium ethanol and the like can be used.
- During the reaction, a condensation reaction occurs first to form the skeleton of the pyrrole ring, and a 2,4-dimethyl substituent is introduced at the same time. The reaction conditions need to be controlled at a suitable temperature and reaction time. Generally, the reaction is refluxed under heating conditions for several hours.
2. ** Modification of formylation **:
- The resulting 2,4-dimethyl pyrrole-3-carboxylic acid ethyl ester is formylated. The Vilsmeier-Haack reaction can be used again. Similar to the above-mentioned formylation with 2,4-dimethyl pyrrole as a raw material, a formyl group is introduced at the 5-position of the pyrrole ring to obtain the target product 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester.

Ethyl 5 - formyl - 2,4 - dimethyl - 1H - pyrrole - 3 - carboxylate is an organic compound whose physical properties are worthy of investigation.
Looking at its appearance, it is usually in a solid state, which is easy to store and operate. This is an important property for many starting materials for chemical reactions. Furthermore, this compound has a specific melting point. The melting point is the temperature at which a substance changes from solid to liquid. The melting point of this compound is of great significance for the detection of its purity and the control of the reaction process at different temperatures.
Discusses solubility, which exhibits unique solubility properties in common organic solvents. In some organic solvents such as ethanol and ether, it may have good solubility. This property makes it possible to skillfully select suitable solvents according to the needs of the reaction, promote the smooth progress of the reaction, and also help the separation and purification of the product.
This substance also has a specific density. Density is a physical constant of the substance, reflecting the mass of the substance per unit volume. Knowing its density, when measuring a certain mass of the substance for the reaction, the required volume can be accurately obtained through density conversion, so as to accurately control the proportion of the reaction material and ensure that the reaction proceeds as expected.
In addition, the refractive index of this substance is also an important physical property. The refractive index can reflect the degree of change in the direction of light propagation in the substance. By measuring the refractive index, the purity of the substance can be identified or the composition of the mixture can be determined.
In summary, the physical properties of Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate, such as appearance, melting point, solubility, density and refractive index, have a profound impact on its application in organic synthesis, analysis and testing.

Wen Jun asked about the market prospect of "Ethyl 5 - formyl - 2,4 - dimethyl - 1H - pyrrole - 3 - carboxylate", and I will analyze it with quaint words.
This substance is a key intermediate in organic synthesis and has important applications in the fields of medicine, pesticides and materials science. Looking at medicine, it can be used as a lead compound, which can be delicately modified to become a good medicine for treating diseases. In the pesticide industry, it may be the cornerstone of the creation of high-efficiency and low-toxicity pesticides to protect farmers and mulberry. As for material science, it may also be the starting material for the development of novel functional materials, opening a new chapter.
As far as the market is concerned, with the booming development of the global pharmaceutical and pesticide industries, the demand for them is also increasing day by day. Coupled with the innovation and exploration in the field of materials science, the reliance on such intermediates is even more. Although competition may exist, the expansion of new application fields, such as the exploration of new energy materials, has opened up a vast world for it.
However, the market is changing and technological innovation is like a torrent. If we can improve the synthesis process, improve the yield and reduce the cost, we will be able to take the lead in the market. And the requirements of environmental protection are becoming more and more stringent, and the development of green synthesis paths is also a move in line with the times. In this way, "Ethyl 5 - formyl - 2,4 - dimethyl - 1H - pyrrole - 3 - carboxylate" is expected to shine in the market and achieve extraordinary results.