ethyl 5-formyl-1H-pyrrole-2-carboxylate

Ethyl-5-formyl-1H-pyrrole-2-carboxylic acid ester, its chemical structure is based on a pyrrole ring. This pyrrole ring has no substituent at position 1 and is only connected to a hydrogen atom. At position 2, it is related to a ethyl carboxylate group, and at position 5, it is connected to a formyl group.
The pyrrole ring is a five-membered heterocyclic ring containing a nitrogen atom. It has a conjugated structure, and the electron cloud is distributed over the entire ring, resulting in its unique chemical properties. The carboxylic acid ethyl ester group at the
2 position, -COOCH < CH < CH >, contains an ester functional group. In this ester group, the carbonyl carbon atom is connected to the oxygen atom by a double bond, and the ethoxy group connected to the oxygen atom gives the structure a specific reactivity. For example, under basic or acidic conditions, the ester group can undergo hydrolysis to generate corresponding carboxylic acids and alcohols. The formyl group at the
5 position, -CHO, is an aldehyde functional group. In the aldehyde group, the carbonyl carbon atom is connected to the hydrogen atom. This structure allows the compound to participate in many reactions specific to aldose, such as addition reactions with nucleophiles and oxidation reactions with weak oxidants to form carboxylic acids. Such a chemical structure endows ethyl-5-formyl-1H-pyrrole-2-carboxylic acid esters with unique physical and chemical properties, and has important applications in organic synthesis and other fields.

Ethyl-5-formyl-1H-pyrrole-2-carboxylic acid ester, which has a wide range of uses. In the field of organic synthesis, it is often a key intermediate. It can undergo a variety of chemical reactions to build complex organic molecules. For example, by condensation with specific reagents, pyrrole derivatives with specific properties and structures can be generated. Such derivatives are valuable in the field of medicinal chemistry, or can be used as lead compounds to develop new drugs and play therapeutic effects on specific diseases.
In the field of materials science, materials prepared from this raw material may have unique optoelectronic properties. For example, with appropriate modification and polymerization, the obtained materials may be applied to organic Light Emitting Diodes (OLEDs) to improve their luminous efficiency and stability, and then promote the development of display technology.
Furthermore, in the field of total synthesis of natural products, ethyl-5-formyl-1H-pyrrole-2-carboxylic acid esters also have important uses. Many natural products contain pyrrole units in their structures. By using these compounds as starting materials, ingeniously designed synthesis routes may be able to achieve total synthesis of target natural products, which will facilitate in-depth research on the biological activity and pharmacological effects of natural products.

There are many ways to synthesize ethyl 5-formyl-1H-pyrrole-2-carboxylate (5-formyl-1H-pyrrole-2-carboxylate), which is a common one in Jundao.
First, pyrrole is used as the starting material. Under specific reaction conditions, the carboxyl ethyl ester group is introduced first at the 2-position of pyrrole, and then at the 5-position through a suitable formylation reagent. This process requires fine control of the reaction conditions, and the choice of formylation reagents is crucial. For example, the Vilsmeier-Haack reagent can be used to react in a suitable temperature and solvent system to effectively introduce formyl groups.
Second, start from the compound containing the pyrrole ring precursor. Such precursors may already have part of the target structure, and through a series of functional group transformations, such as esterification, oxidation, and reduction, the target molecular structure is gradually constructed. Among them, the esterification reaction converts the carboxyl group into ethyl ester group, and the oxidation or reduction process can precisely regulate the formation of formyl groups.
Furthermore, through multi-step tandem reaction. Starting with a simple compound, in the same reaction system, a pyrrole ring is constructed through continuous reaction and the desired carboxyethyl ester and formyl group are introduced at the same time. Although this method can simplify the operation steps, it requires extremely high synergy of reaction conditions, and each step needs to be adapted to each other to ensure the efficient progress of the overall reaction.
The above methods have their own advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider many factors such as raw material availability, reaction cost, yield and purity requirements, and make a careful choice to achieve the purpose of synthesis.

Ethyl + 5 - formyl - 1H - pyrrole - 2 - carboxylate is 5 - formyl - 1H - pyrrole - 2 - carboxylate, the physical properties of this substance are quite important, related to its many uses.
Looking at its properties, at room temperature, 5 - formyl - 1H - pyrrole - 2 - carboxylate is often liquid, with a clear texture, like a clear spring, in color, or colorless to light yellow, like morning light sprinkled on water waves, slightly light color. < Br >
When it comes to solubility, it is very easy to dissolve in organic solvents, such as common ethanol and ether, just like fish get water. This property is due to the interaction between its molecular structure and the molecules of organic solvents. However, in water, it is difficult to dissolve, just like the barrier between oil and water, and it is difficult to blend. This is due to the difference in molecular polarity and water.
A boiling point is about a specific temperature range. At this temperature, the liquid seems to break free and rise into a gaseous state. The value of this boiling point depends on the strength of intermolecular forces, such as van der Waals forces and hydrogen bonds. < Br >
Melting point is also a key physical property. When the temperature drops to a certain value, the substance solidifies from liquid to solid, just like water turns into ice when it meets cold. The melting point of ethyl 5-formyl-1H-pyrrole-2-carboxylate reveals the critical condition for the conversion of its solid state to liquid state.
In terms of density, its density is relatively specific. Under a given temperature and pressure, the mass per unit volume is constant. This property is of great significance in many practical application scenarios, such as the separation and mixing of substances.
In addition, its volatility cannot be ignored. Although it is not highly volatile, it will gradually disperse in the air under appropriate conditions. This property affects the choice of its storage and use environment.
The physical properties of 5-formyl-1H-pyrrole-2-carboxylic acid ethyl ester are interrelated and jointly determine its application in many fields such as chemical industry and medicine.

The Chinese name of ethyl 5-formyl-1H-pyrrole-2-carboxylate is ethyl 5-formyl-1H-pyrrole-2-carboxylate. In the current market outlook, this compound has development opportunities in various fields such as medicine and materials.
In the field of medicine, pyrrole compounds often have diverse biological activities. The structure of 5-formyl-1H-pyrrole-2-carboxylate may make it a key intermediate for the synthesis of specific drugs. With the deepening of pharmaceutical research and development, the demand for compounds with unique structures and activities is increasing. They may gain attention in the creation of antibacterial, anti-tumor and other drugs due to their own structural characteristics. Over time, new drugs based on this compound may come out, and the prospects are quite promising.
In the field of materials, with the rise of functional materials research, compounds containing pyrrole structures can be chemically modified to construct materials with special photoelectric properties. 5-formyl-1H-pyrrole-2-carboxylate can be modified by various chemical reactions due to its formyl and ester groups, or used to prepare organic Light Emitting Diodes, sensors and other materials. The market demand for such materials is growing, so it also has potential in the field of materials.
However, its market development also faces challenges. Optimization of synthetic processes is the top priority. To achieve large-scale production to meet market demand, it is necessary to improve synthesis efficiency and reduce costs, which is related to whether it can be widely used in the market. And the market competition is also fierce. There are many similar or similar functional compounds. To stand out, it is necessary to achieve a delicate balance between performance and cost. Although there are challenges, opportunities coexist. With reasonable research and development and promotion, "ethyl 5 - formyl - 1H - pyrrole - 2 - carboxylate" should occupy a place in the market.