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What is the main use of Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate?
Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate, that is, ethyl 4H-thiopheno [2,3-d] pyrrole-5-carboxylate, has a wide range of uses. In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of various biologically active compounds. Or because of its unique structure, it can be combined with specific targets in organisms. Therefore, in the process of creating new drugs, such as antibacterial, antiviral and even anti-cancer drugs, it is often favored by chemists. It is used as a starting material to build an active molecular skeleton.
In the field of materials science, because of the photoelectric properties endowed by its special chemical structure, it can participate in the preparation of organic optoelectronic materials. Such materials show potential application value in the fields of organic Light Emitting Diodes (OLEDs), solar cells, etc., or can improve the properties of charge transport and luminous efficiency of materials.
In the field of organic synthetic chemistry, as a special class of nitrogenous and sulfur heterocyclic ester compounds, they can participate in many organic reactions, such as nucleophilic substitution and condensation, by virtue of their reactivity of ester groups and heterocyclic rings, providing the possibility to construct more complex and diverse organic molecular structures, and promoting the development and innovation of organic synthetic chemistry.
What are the synthetic methods of Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate
Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate is an organic compound. The synthesis method of ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate has been studied by chemists throughout the ages. The following are common synthesis methods.
First, thiophene and pyrrole derivatives are used as starting materials. First, thiophene is reacted in a specific way to introduce a functional group at a suitable position. This functional group needs to be able to condensate with pyrrole derivatives under suitable conditions. When condensation occurs, or a specific catalyst is used to catalyze the combination of the two to form a key carbon-carbon bond or a carbon-heteroatomic bond to construct the basic skeleton of 4H-thieno [2,3-d] pyrrole. Subsequently, the skeleton is carboxylated, and the carboxyl group is introduced at the appropriate position, and then the carboxyl group is converted into ethyl ester group, so that Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate is obtained. In this process, each step of the reaction requires strict control of the reaction conditions, such as temperature, reaction time, and the proportion of reactants. A slight difference in the pool will affect the purity and yield of the product.
Second, other heterocyclic compounds containing sulfur and nitrogen can be started. The heterocyclic ring is modified and modified through multi-step reaction. For example, a partial heterocyclic structure is formed by cyclization reaction, and then nucleophilic substitution, electrophilic substitution and other reactions are used to gradually introduce the required groups, and finally the molecular structure of Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate is constructed. This path requires a good understanding of various reaction mechanisms in order to skillfully design the reaction route and achieve the purpose of synthesis.
Third, there are also synthesis strategies using transition metal catalysis. Transition metal catalysts can effectively promote some difficult reactions and improve reaction efficiency and selectivity. For example, transition metal catalysts such as palladium and copper are used to catalyze the coupling reaction between substrates, so as to quickly construct the structure of the target compound. Although this method is efficient, the cost of transition metal catalysts is higher, and the post-reaction treatment may need to consider metal residues and other issues.
All synthesis methods have their own advantages and disadvantages. Chemists need to choose carefully according to actual needs, such as product purity, cost, difficulty of reaction conditions, etc., in order to achieve the ideal synthesis effect.
What are the physical properties of Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate
Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate, Chinese name or ethyl 4H-thiopheno [2,3-d] pyrrole-5-carboxylate. Although this physical property is not directly stated in ancient books, it can be deduced from the chemical theory.
It is an organic compound with a specific molecular structure. It is composed of a ring system of thiophene and pyrrole, and is connected with an ethyl ester group. From a structural perspective, it should have a certain stability. The conjugated structure of the cap ring system makes the distribution of the electron cloud more delocalized and increases its structural stability.
In terms of physical properties, it may be solid or liquid under normal conditions. Its melting point and boiling point are affected by the intermolecular force. The existence of van der Waals force between molecules, the existence of ethyl ester group, or cause it to have a certain polarity, so that the intermolecular force is slightly stronger, and the melting point, boiling point or non-extremely low.
In terms of solubility, according to the principle of "similar phase dissolution", it is an organic compound, and it may have a certain solubility in common organic solvents, such as ethanol, ether, dichloromethane, etc. However, because the molecule contains polar groups and non-polar rings, the solubility in water may not be good, and water is a strong polar solvent, which is very different from the structure of the compound.
Density may be similar to that of common organic compounds, between water and common organic solvents. Due to its relative molecular weight and molecular accumulation mode, its density has this characteristic.
The physical properties of Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate are determined by its unique molecular structure. Its stability, melting point, solubility, density and other properties conform to the general laws of organic compounds, which can be analyzed from the aspects of structure and intermolecular forces.
What are the chemical properties of Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate
Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate is an organic compound with specific chemical properties. Its sulfur-containing heterocycle is combined with pyrrole ring, and there is ethyl ester group. This structure gives it unique chemical activity and properties.
In terms of physical properties, under normal circumstances, it may be a solid with a certain melting point and boiling point. The specific values vary according to the purity and measurement conditions. It has certain solubility in organic solvents, such as common organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc., but poor solubility in water due to limited molecular polarity.
From the perspective of chemical properties, ethyl ester groups can undergo hydrolysis reactions. Under acidic or basic conditions, it can be hydrolyzed to 4H-thieno [2,3-d] pyrrole-5-carboxylic acid and ethanol. Under alkaline conditions, the hydrolysis reaction is easier to carry out, because the hydroxide ion will push the reaction forward. At the same time, it can participate in the reverse reaction of esterification reaction, react with alcohols under acid catalysis, and adjust the ester structure. The heterocyclic structure in the
molecule has certain aromaticity due to the presence of conjugated systems, and can undergo electrophilic substitution reactions. Electrophilic reagents will attack positions with high electron cloud density, such as halogenation reactions, nitrification reactions, sulfonation reactions, etc. For example, under the action of suitable catalysts, electrophilic substitution can occur with halogens, and halogen atoms can replace hydrogen atoms at specific positions on the heterocyclic ring.
In addition, it may participate in some reactions that build carbon-carbon bonds, such as palladium-catalyzed coupling reactions. This is of great significance in the field of organic synthesis and can be used to build more complex organic molecular structures, providing key steps for the synthesis of drugs, natural products, etc.
What is the price range of Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate in the market?
Ethyl 4H-thieno [2,3-d] pyrrole-5-carboxylate is an important compound in organic synthesis, but it is difficult to determine its price in the market price range. This is due to many reasons, which affect its price.
The first to bear the brunt is the difficulty of preparation. If the synthesis method is complicated, rare reagents are required, or the reaction conditions are harsh, such as precise temperature control, pressure control, and multi-step reaction accumulation, the cost will be high, and the price will rise accordingly. On the contrary, if the preparation path is simple, the reagents used are common and inexpensive, the price can be close to the people.
Furthermore, the market supply and demand situation also has a great impact. If many pharmaceutical companies and scientific research institutions have strong demand for this product, but the supply is limited, the so-called "rare is expensive", the price will rise. If the market demand is limited, but the supply is sufficient, the price will be reduced for promotional sales.
In addition, the scale of production also affects the price. In large-scale production, due to the scale effect, the unit cost may be reduced, and the price is expected to decrease. Small-scale production is difficult to reduce, and the price is often high.
As far as I know, the price of Ethyl 4H - thieno [2,3 - d] pyrrole - 5 - carboxylate on the market varies widely, either a few dollars per gram, or hundreds of yuan per gram, or even higher. If you want an accurate price, you need to consult the chemical raw material supplier in detail, or check it carefully on the chemical product trading platform.