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What is the main use of ethyl 4-methyl-2-pyrrolecarboxylate/40611-85-6?
Ethyl 4-methyl-2-pyrrolecarboxylate (CAS No.: 40611-85-6) has a wide range of uses.
In the field of pharmaceutical chemistry, it is often a key intermediate for the synthesis of many drugs. Due to its unique chemical and biological activities of the pyrrole ring structure, compounds with specific pharmacological activities can be constructed by chemical modification. For example, in the synthesis of some antidepressant drugs and antibacterial drugs, it is used as the starting material. By modifying its structure, such as introducing specific functional groups on the pyrrole ring, the drug is given better pharmacological properties and improved drug efficacy and selectivity. < Br >
In the field of organic synthesis, it is also an extremely important building block. It can participate in a variety of classical organic reactions, such as nucleophilic substitution reactions, cyclization reactions, etc. Through nucleophilic substitution, different substituents can be introduced at specific positions of pyrrole rings to expand the structural diversity of compounds; through cyclization reactions, more complex cyclic compounds can be further constructed, laying the foundation for the synthesis of natural products, functional materials, etc.
In the field of materials science, some polymers or organic materials synthesized from this raw material exhibit unique optoelectronic properties. For example, introducing it into the polymer backbone may endow the material with good fluorescence properties, which is expected to be applied to Light Emitting Diodes, sensors and other fields, providing new ideas for material design and development.
What are the physical properties of ethyl 4-methyl-2-pyrrolecarboxylate/40611-85-6
Ethyl 4-methyl-2-pyrrolecarboxylate (CAS No.: 40611-85-6) is an organic compound. Its physical properties are as follows:
In terms of view, this substance is often colorless to light yellow liquid. It exists stably at room temperature and pressure. However, it has a certain sensitivity to light and air. If it is exposed to light and air for a long time, or causes it to undergo a chemical reaction, the color gradually changes.
Smell it, it has a weak and special smell, but the smell is not pungent. Compared with common organic solvents, its smell is relatively mild.
The boiling point is about a specific temperature range, which varies slightly due to specific test conditions and is roughly within a certain range. The characteristics of the boiling point make it possible to separate by distillation during the separation and purification process, according to the difference between its boiling point and other substances.
As for the melting point, it is at a relatively low temperature, which makes the compound liquid at room temperature. The lower melting point also reflects the characteristics of its intermolecular forces, and the intermolecular interactions are weak, resulting in less energy required for its solid state to be converted into a liquid state.
In terms of solubility, it can be soluble in common organic solvents such as ethanol, ether, and dichloromethane. This solubility is due to the similar interaction between its molecular structure and organic solvent molecules, such as van der Waals force, hydrogen bonding, etc., and follows the principle of "similar miscibility". However, the solubility in water is very small, because its molecular polarity is weak, and the force between water molecules cannot rival the hydrogen bond between water molecules, so it is difficult to dissolve in water. This solubility characteristic is of great significance in the selection of solvents, product separation and purification of organic synthesis reactions.
Is ethyl 4-methyl-2-pyrrolecarboxylate/40611-85-6 chemically stable?
The stability of the chemical properties of fuethyl 4-methyl-2-pyrrole carboxylate (CAS No. 40611-85-6) is related to many chemical scenarios. This compound has a specific structure, and the pyrrole ring is connected to ethyl ester and methyl groups.
In terms of stability, in a conventional mild environment, if there is no specific chemical reaction conditions to trigger, its structure can be maintained relatively stable. Although the pyrrole ring has certain electron cloud distribution characteristics, the surrounding substituents, such as methyl and ethyl ester groups, affect its activity to a certain extent. Methyl groups act as the power supply group, which can increase the electron cloud density of the pyrrole ring, while ethyl ester groups interact with the pyrrole ring due to the existence of carbonyl and ethoxy groups.
When there are no active reagents such as strong oxidants, strong acids, and strong bases at normal room temperature and pressure, the molecular structure of this compound can be maintained for a long time, and its chemical properties have not changed significantly. However, in case of strong acids, the pyrrole ring may be protonated, which may change its electron cloud distribution and reactivity; in case of strong bases, the ethyl ester group may undergo reactions such as hydrolysis, which will affect its overall stability. And if there is strong oxidant intervention or pyrrole epoxidation, the conjugate structure will be destroyed and the stability will be damaged. Therefore, its stability is not absolute, but varies depending on the chemical environment.
What are the synthesis methods of ethyl 4-methyl-2-pyrrolecarboxylate/40611-85-6
The synthesis method of fuethyl-4-methyl-2-pyrrole carboxylate (CAS No.: 40611-85-6) is of interest in the field of organic synthesis. In the ancient meaning of "Tiangong Kaiwu", although there is no direct correspondence to the synthesis of this specific compound, it can be compared to the current synthesis method due to its technological wisdom.
One, or follow the esterification reaction. Use 4-methyl-2-pyrrolitic acid and ethanol as raw materials, and add suitable catalysts, such as concentrated sulfuric acid. This is because concentrated sulfuric acid has catalytic activity, which can promote the reaction of acid and alcohol, so that the two dehydrate and condensate to form esters. At the time of the reaction, the temperature needs to be controlled in an appropriate range, about 100-120 ° C. This temperature can not only accelerate the reaction process, but also avoid the decomposition of raw materials and products. And the reaction system needs to be carried out in a reflux device to ensure that the reactants are fully contacted and the yield is increased.
Second, the acyl chloride method can be used. First, 4-methyl-2-pyrrolitic acid is converted into acyl chloride, which is often reacted with thionyl chloride. Sulfoxide chloride is very active, which can replace the hydroxyl group of the carboxylic acid with chlorine atoms to form an acyl chloride. Then the acyl chloride reacts with ethanol in the presence of a base, which can neutralize the generated hydrogen chloride and promote the positive reaction. Common bases such as pyridine. In this process, the reaction conditions also need to be carefully regulated. For example, the reaction temperature should be started at 0-5 ° C, and then gradually raised to room temperature to obtain satisfactory results.
Third, the transesterification method is also feasible. Using methyl 4-methyl-2-pyrrole carboxylate and ethanol as raw materials, add an appropriate amount of transesterification catalyst, such as sodium methoxide. The transesterification reaction can occur under relatively mild conditions, generally at a temperature of 60-80 ° C. Through the exchange of groups, the synthesis of the target product ethyl-4-methyl-2-pyrrole carboxylate can be achieved. During the reaction process, the proportion of reactants and the amount of catalyst should be carefully considered to optimize the synthesis effect.
What is the price range of ethyl 4-methyl-2-pyrrolecarboxylate/40611-85-6 in the market?
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