ethyl 3-(ethoxycarbonyl)-1,4-dimethyl-1H-pyrrole-2-acetate

Ethyl + 3- (ethoxycarbonyl) -1,4-dimethyl-1H-pyrrole-2-acetate, that is, 3- (ethoxycarbonyl) -1,4-dimethyl-1H-pyrrole-2-ethyl acetate, this substance has a wide range of uses.
In the field of organic synthesis, it is a key class of intermediates. Because the molecule is rich in active groups such as ester groups and pyrrole rings, a series of pyrrole derivatives can be prepared by various chemical reactions, such as hydrolysis, esterification, substitution, etc. Pyrrole derivatives are of great significance in the field of medicinal chemistry. Many biologically active drug molecules have pyrrole rings as the core structure. This compound is used as the starting material, and after structural modification and modification, new drugs with specific pharmacological activities may be obtained.
In the field of materials science, the pyrrole derivatives prepared by this method may have unique optoelectronic properties. The conjugated structure of pyrrole rings endows materials with certain electron transport capabilities, or can be applied to the preparation of organic semiconductor materials, and has emerged in devices such as organic Light Emitting Diode (OLED) and organic solar cells, providing a material basis for the research and development of new optoelectronic devices.
In the field of fine chemicals, it can be used as an important raw material for the synthesis of fine chemicals such as special fragrances and dyes. With its unique molecular structure, the synthesized fragrances may have a unique aroma, and the dyes may have excellent dyeing properties and color fastness, meeting the specific needs of different industries for fine chemicals.

There are many ways to synthesize ethyl 3- (ethoxycarbonyl) -1, 4-dimethyl-1H-pyrrole-2-acetate. In the past, people tried to synthesize nitrogen-containing heterocycles as a basis, and created multiple methods to prepare such compounds.
One method can also be started from a suitable β-ketone ester with ammonia or amines. First, the β-ketone ester is condensed with ammonia or specific amines to form a pyrrole ring precursor. In the meantime, the carbon-oxygen double bond in the molecule interacts with the amino group, and after dehydration and other steps, it closes into a pyrrole ring. On this basis, an alkylation reaction is carried out, and a methyl group is introduced to obtain methyl substitution at the 1st and 4th positions of the pyrrole ring. After the acylation reaction, ethoxycarbonyl is introduced at the 3rd position of the pyrrole ring, and finally ethyl acetate is connected at the 2nd position to obtain ethyl 3- (ethoxycarbonyl) -1,4-dimethyl-1H-pyrrole-2-acetate.
Another method can be started from 1,4-dicarbonyl compounds. The 1,4-dicarbonyl compound is synthesized with ammonia or amine under acid catalysis by Paal-Knorr synthesis method. In this process, the carbonyl groups at both ends of the 1,4-dicarbonyl compound are condensed with ammonia or amine to form a pyrrole ring. Thereafter, methyl, ethoxycarbonyl and ethyl acetate are introduced in sequence as in the previous method. After a multi-step reaction, the target product can also be obtained.
Furthermore, the coupling reaction catalyzed by transition metals can be used. First synthesize the intermediate containing pyrrole ring, and then use transition metal catalysts such as palladium and copper to couple the intermediate with reagents containing ethoxycarbonyl, methyl and ethyl acetate. This approach requires precise control of the reaction conditions, selection of appropriate ligands and bases, in order to promote the smooth progress of the reaction and obtain the target compound.
All synthesis methods have advantages and disadvantages. Depending on the availability of raw materials, the difficulty of reaction, the yield, and the cost, the optimal method can be selected to synthesize ethyl 3- (ethoxycarbonyl) -1, 4-dimethyl-1H-pyrrole-2-acetate.

"Tiangong Kaiwu" is a scientific and technological work written by Song Yingxing in the Ming Dynasty. It records various skills such as agriculture and engineering in ancient Chinese. However, today's "ethyl 3- (ethoxycarbonyl) -1,4 - dimethyl - 1H - pyrrole - 2 - acetate" is a modern chemical term. It is an organic compound. It is difficult to find a direct corresponding expression in ancient Chinese. Today, in the style of ancient Chinese, its physical and chemical properties are outlined as follows:
This compound is a colorless to light yellow oily liquid, with a certain volatility, and is relatively stable at room temperature and pressure. Looking at its physical properties, its boiling point is about a certain temperature range. Due to the force between molecules, the boiling point is affected by the structure. Its density is moderate, insoluble in water, but it can be miscible with most organic solvents. This is due to the principle of similar miscibility, and its molecular structure has certain non-polar characteristics.
In terms of its chemical properties, the molecule contains an ester group and a pyrrole ring structure. The ester group can undergo hydrolysis, and the hydrolysis rate varies under acidic or alkaline conditions. In an alkaline environment, hydrolysis is more rapid, generating corresponding carboxylic salts and alcohols. Pyrrole rings have certain aromatic properties and can undergo electrophilic substitution reactions, such as halogenation and nitrification. Because of the substituents such as methyl and ethoxycarbonyl on the ring, it has an impact on the reaction check point and activity. Methyl group is the electron carrier group, which can increase the electron cloud density of pyrrole ring, and the electrophilic substitution reaction is more likely to occur in the adjacent and para-position; while ethoxycarbonyl group is the electron-withdrawing group, which has the passivation of benzene ring, which inhibits the reactivity to a certain extent and affects the reaction regioselectivity. It can be used as an important intermediate in the field of organic synthesis to construct more complex organic molecular structures through a series of reactions.

I don't know what the price range of "ethyl 3- (ethoxycarbonyl) -1, 4-dimethyl-1H-pyrrole-2-acetate" is on the market. This compound is not a well-known common substance, and its price is often influenced by a variety of reasons.
First, the purity has a great impact. If it is high purity, it is suitable for high-end applications such as fine chemical experiments or pharmaceuticals, and the price must be high; if the purity is slightly lower, it is used in general chemical synthesis, and the price may drop.
Second, the relationship between supply and demand is critical. If the market is in demand, and the supply is scarce, the price will rise; if the supply exceeds the demand, the price will decline.
Third, the difficulty of preparation is also related. If the preparation requires complicated steps, special raw materials or conditions, the cost is high, and the price is also high; the preparation is simple, and the price is close to the people.
Fourth, the manufacturer and the brand are different, and the price is also different. Well-known large factories, due to good quality control and reputation, the price may be high; small factories compete for the market, the price may be low.
Because I don't know the details of the current market, it is difficult to determine its price range. If you want to know, you can consult chemical reagent suppliers, or check chemical product trading platforms to get accurate price information.

Ethyl 3- (ethoxycarbonyl) -1,4 - dimethyl - 1H - pyrrole - 2 - acetate (3 - ethoxycarbonyl - 1,4 - dimethyl - 1H - pyrrole - 2 - ethyl acetate) should pay attention to the following matters during use:
First, it is related to the characteristics of the material. This compound is an organic ester, and its properties must be well known. Esters have a specific odor, and some of them may be volatile in the air. When taking it, be careful to avoid inhaling volatile gases, because it may irritate the respiratory tract. In addition, esters may undergo hydrolysis under certain conditions. Therefore, when storing, it should be ensured that the environment is dry and away from water vapor to prevent its deterioration due to hydrolysis and affect the subsequent use effect.
Second, the operating environment. The use field needs to be well ventilated, so that possible volatile gases can be dissipated in time, reducing the concentration of harmful substances in the air, and ensuring the safety of operators. If it is operated in a laboratory, a fume hood is a necessary facility, and all operations involving the compound should be properly carried out in the fume hood. At the same time, the operating area should be kept away from fire sources and high temperatures. Because it is an organic compound, it is flammable, and it is dangerous to encounter open flames, hot topics or cause combustion. Therefore, the operating environment temperature should be strictly controlled, and fireworks are strictly prohibited.
Third, access and operation specifications. When taking the compound, be sure to use clean and dry utensils to prevent impurities from mixing in. Weighing should be accurate. According to the experimental or production requirements, operate with the help of high-precision balances to ensure the accuracy of the dosage. When participating in chemical reactions, it is necessary to strictly control the reaction conditions, such as temperature, reaction time, and the proportion of reactants. Because of the presence of functional groups such as ester groups in its structure, the reactivity may vary under different conditions. If there is a slight carelessness, or the reaction results are deviated, the expected goal cannot be achieved.
Fourth, safety protection. Operators must wear appropriate protective equipment, such as experimental clothing, gloves and goggles. Experimental clothing can prevent compounds from spilling on clothing, and gloves can avoid direct contact with the skin. Due to some organic compounds or absorption through the skin, damage to the human body can be caused. Goggles can effectively protect the eyes and prevent accidental splashing from causing eye damage. If you accidentally touch the skin or eyes, you should immediately rinse with plenty of water and seek medical attention as appropriate.