Ethyl 3 Amino 5 Methyl 1h Pyrrole 2 Carboxylate
pyridine pyrrole pyrazine piperidine piperazine

ethyl 3-amino-5-methyl-1H-pyrrole-2-carboxylate

    Specifications

    HS Code

    288265

    Chemical Formula C9H14N2O2
    Molecular Weight 182.22 g/mol
    Appearance Typically a solid
    Physical State At Room Temp Solid
    Odor May have a characteristic odor
    Solubility In Water Low solubility
    Solubility In Organic Solvents Soluble in some organic solvents
    Melting Point Needs experimental determination
    Boiling Point Needs experimental determination
    Stability Stable under normal conditions
    Flash Point Needs experimental determination
    Density Needs experimental determination

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    General Information
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    Frequently Asked Questions

    As a leading ethyl 3-amino-5-methyl-1H-pyrrole-2-carboxylate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of ethyl 3-amino-5-methyl-1H-pyrrole-2-carboxylate?
    Ethyl 3 - amino - 5 - methyl - 1H - pyrrole - 2 - carboxylate is an organic compound. It has many chemical properties.
    In terms of physical properties, this compound is often solid, due to intermolecular forces. Its melting point and boiling point are closely related to the molecular structure. There are functional groups such as amino, methyl and ester groups in the molecule, and these functional groups interact with each other to determine its melting and boiling point. The existence of ester groups causes a certain van der Waals force between molecules, but amino groups can form hydrogen bonds, which enhances the intermolecular forces, causing its melting and boiling point to have a specific value.
    Chemically, amino groups are alkaline. Because the nitrogen atom has lone pairs of electrons and can accept protons, it is easy to combine with protons in an acidic environment, and acid-base reactions occur. In case of strong acid, the amino group will protonate and form corresponding salts.
    The ester group is active and can undergo hydrolysis. Under acidic or basic conditions, ester groups can be hydrolyzed. When acidic hydrolysis, 3-amino-5-methyl-1H-pyrrole-2-carboxylic acid and ethanol are formed; when alkaline hydrolysis, the corresponding carboxylic acid and ethanol are formed, and the hydrolysis is more complete under alkaline conditions, because the formed carboxylic acid is stable.
    Methyl is relatively stable and does not react easily under normal conditions. However, under special conditions, such as the presence of strong oxidants or high temperature light, methyl groups can be oxidized or undergo free radical substitution reactions.
    In addition, the conjugate structure of the compound imparts certain electron delocalization properties, which affect its reactivity and spectral properties. In the field of organic synthesis, it is often used as an intermediate to construct more complex organic molecular structures by reacting with various functional groups.
    What is the synthesis method of ethyl 3-amino-5-methyl-1H-pyrrole-2-carboxylate?
    The process of preparing ethyl-3-amino-5-methyl-1H-pyrrole-2-carboxylic acid esters is an important issue in organic synthesis. Its synthesis often requires delicate steps and suitable reagents.
    First, or take suitable starting materials, such as pyrrole derivatives with relevant substituents. To obtain this compound, methyl-containing pyrrole is often used as the initial material, and the amino group and ester group are introduced through multi-step conversion.
    Or a specific halogenating agent can be used to halogenate the pyrrole at a suitable position, and then an amination agent, such as an ammonia derivative, is introduced through a nucleophilic substitution reaction. In this step, it is necessary to pay attention to the control of reaction conditions, such as temperature and solvent selection, to prevent side reactions.
    As for the introduction of ester groups, aminylated pyrrole derivatives and reagents containing ethyl ester groups can be esterified under alkali catalysis. The amount and type of base have a great impact on the reaction process and must be carefully considered. Or pyrrole derivatives containing carboxyl groups can be prepared first, and then converted into ethyl esters through esterification steps.
    The choice of solvent is also key. Common organic solvents such as dichloromethane, N, N-dimethylformamide can provide a suitable environment for the reaction and promote the dissolution of the reactants and the progress of the reaction. In the
    reaction process, it is extremely important to monitor the reaction process. Thin layer chromatography (TLC) can be used to observe the consumption of reactants and the formation of products, and to adjust the reaction conditions in a timely manner. After the reaction is completed, the pure ethyl-3-amino-5-methyl-1H-pyrrole-2-carboxylic acid ester can be obtained through separation and purification methods, such as column chromatography, recrystallization, etc. Each step of the reaction conditions and the delicate preparation of reagents are the key to the successful synthesis of this compound.
    What are the applications of ethyl 3-amino-5-methyl-1H-pyrrole-2-carboxylate?
    Ethyl-3-amino-5-methyl-1H-pyrrole-2-carboxylic acid ester, this compound has wonderful uses in medicine, materials and other fields.
    In the field of medicine, it can be used as a key intermediate for the synthesis of various biologically active compounds. For example, in the development of anti-tumor drugs, new drugs with high selective inhibitory activity on tumor cells can be obtained by modifying the structure of the compound. The structure of Gain pyrrole ring is common in many natural active molecules, and amino and ester groups can participate in various chemical reactions, providing the possibility for the construction of complex active molecules.
    In the field of materials, ethyl-3-amino-5-methyl-1H-pyrrole-2-carboxylic acid esters also have outstanding performance. They can be introduced into polymer materials through specific reactions to impart special properties to the materials. For example, by making them participate in polymerization reactions, the resulting polymers may have unique optical and electrical properties. In the field of optoelectronic materials, they can be used as luminescent layer materials for organic Light Emitting Diodes (OLEDs), and their structural properties can achieve efficient luminescence.
    In addition, in the field of organic synthetic chemistry, they can be used as characteristic structural units to build more complex organic molecular structures. Chemists can expand the structural diversity of organic molecules by performing various functional group conversion reactions on them, laying the foundation for the development of novel functional materials and drugs. In short, ethyl-3-amino-5-methyl-1H-pyrrole-2-carboxylic acid esters have potential application value in many fields, and with the deepening of research, more innovative applications may be discovered.
    What is the market outlook for ethyl 3-amino-5-methyl-1H-pyrrole-2-carboxylate?
    Nowadays, there is a name ethyl + 3 - amino - 5 - methyl - 1H - pyrrole - 2 - carboxylate, which is very new in the market. This substance is an organic compound, and its use is mostly in the fields of medicine and chemical industry.
    Looking at the chemical industry, this substance is often the key raw material for synthesizing delicate drug molecules. In the early days of pharmaceutical research and development, chemists often used it to construct complex active structures to explore the possibility of new drugs. However, its synthesis method is not easy, the process is complex and the cost is high, which is one of the reasons why it is difficult to enter the market.
    In the pharmaceutical market, although there may be R & D drugs containing this substance, many of them are still in the experimental stage. To cover the development of new drugs, it must go through many trials, from cell experiments to animal experiments, and then to human clinical practice, which takes a long time and poses great risks.
    Furthermore, the production of this substance is strictly regulated by laws and regulations. Chemical production is related to the safety of the environment and human life, and must abide by many norms. From raw material procurement to product disposal, it is necessary to comply with laws, which increases the difficulty and cost of production.
    And market demand is also a major reason. Although it is theoretically useful in pharmaceutical and chemical industries, it is difficult for manufacturers to have the motivation to expand production and promote the market without sufficient actual demand. Therefore, in the current situation, ethyl + 3 - amino - 5 - methyl - 1H - pyrrole - 2 - carboxylate is still in the market, and it is still in the embryonic state. If the process can be advanced, the cost can be reduced, and the demand is gradually increasing, it may be possible to make a difference in the future.
    What are the precautions in the preparation of ethyl 3-amino-5-methyl-1H-pyrrole-2-carboxylate?
    When preparing ethyl 3-amino-5-methyl-1H-pyrrole-2-carboxylic acid ester, many things need to be paid attention to.
    The quality of the first raw material. All raw materials used must be pure and free of impurities, which is the foundation for a smooth reaction and a good product. If there are too many impurities in the raw material, not only will it hinder the reaction, but also many by-products may be formed, which will greatly reduce the purity of the product, and subsequent purification will be difficult.
    The reaction conditions cannot be ignored. Temperature control is extremely critical. This reaction usually requires strict temperature requirements. If the temperature is too high or too low, the reaction rate and product yield will be affected. If the temperature is too high, or the reaction is out of control, and side reactions occur frequently; if the temperature is too low, the reaction will be slow, take a long time, and may not even be able to start. The reaction time also needs to be accurately grasped. If the time is too short, the reaction is not fully functional, and the amount of product is small. If the time is too long, or the product is decomposed, it will also reduce the yield.
    Solvent selection is also important. A suitable solvent can not only help the reactants to disperse evenly and improve the reaction contact, but also affect the direction and rate of the reaction. The selected solvent must have good compatibility with the reactants and products, and the physical properties such as boiling point and polarity meet the needs of the reaction to ensure the smooth progress of the reaction.
    In addition, the monitoring of the reaction process is indispensable. TLC, gas chromatography and other means can be used to gain real-time insight into the reaction process, adjust the reaction conditions in time, and ensure that the reaction proceeds in the expected direction.
    Product purification should not be underestimated. After the reaction, the product often contains impurities, and it needs to be properly purified to obtain high-purity target products. Commonly used purification methods, such as recrystallization, column chromatography, etc., need to be reasonably selected according to the characteristics of the product and impurity properties to achieve the ideal purification effect.
    Preparation of ethyl 3-amino-5-methyl-1H-pyrrole-2-carboxylic acid ester requires careful control of the raw materials, reaction conditions, monitoring, and purification. A little poor pooling may affect the quality and yield of the product.