Ethyl 3,4-dimethylpyrrole-2-carboxylate

Ethyl 3,4-dimethylpyrrole-2-carboxylate, Chinese name ethyl 3,4-dimethylpyrrole-2-carboxylate, this substance is widely used. In the field of pharmaceutical synthesis, it often acts as a key intermediate to help create a variety of new drugs. For example, in the development process of some antibacterial drugs, it can participate in key reaction steps by virtue of its unique chemical structure, which is of great significance to the construction and activity shaping of drug molecules, which can help improve the antibacterial efficacy of drugs and expand the antibacterial spectrum.
In the field of organic synthesis chemistry, it is an important starting material for the construction of complex pyrrole derivatives. Due to the coexistence of pyrrole ring and ester group in its structure, chemists can skillfully modify and derive various organic reactions, such as hydrolysis of ester group, aminolysis, substitution reaction on pyrrole ring, etc., to prepare pyrrole compounds with rich structure and different functions. These compounds also play an important role in the fields of materials science and total synthesis of natural products.
In the field of materials science, some pyrrole compounds derived from them may have special photoelectric properties, which can be applied to the research and development of photoelectric materials such as organic Light Emitting Diode (OLED) and solar cells, providing new possibilities for improving the photoelectric conversion efficiency and stability of materials.
In summary, ethyl 3,4-dimethylpyrrole-2-carboxylate has shown important value in many fields such as medicine, organic synthesis, and materials science, and has made great contributions to promoting scientific research and technological development in various fields.

There are several common methods for the synthesis of ethyl 3,4-dimethylpyrrole-2-carboxylate.
One method can be obtained from a suitable starting material through a multi-step reaction. First take a compound with a specific functional group, such as a pyridine derivative containing a suitable substituent. In this pyridine derivative, a nucleophilic substitution reaction is performed under specific reaction conditions, such as in the presence of a suitable catalyst. The selected nucleophilic reagent can interact with a specific position on the pyridine ring to introduce the desired methyl and carboxylethyl ester moieties. During the reaction, precise control of temperature, reaction time and the ratio of reactants is required, so that the reaction can proceed in the direction of generating the target product. < Br >
Another method can be achieved by gradually constructing pyrrole rings from simple organic small molecules. For example, ethyl acetoacetate compounds and appropriate amine compounds are used as starting materials. The two first undergo a condensation reaction under acidic or basic conditions to form an intermediate containing a preliminary structure. Subsequently, through further cyclization reactions, the pyrrole ring structure is constructed. In this process, the reaction conditions, such as pH and reaction temperature, can be adjusted to selectively generate 3,4-dimethylpyrrole-2-carboxylic acid ethyl ester structures.
In addition, there are also methods of catalysis by transition metals. Select suitable transition metal catalysts, such as palladium, copper and other metal complexes. With specific halogenated hydrocarbons and pyrrole-containing precursors as reactants, cross-coupling reactions occur under the action of transition metal catalysts. This reaction requires careful selection of ligands to enhance the activity and selectivity of the catalyst, so as to effectively synthesize ethyl 3,4-dimethyl pyrrole-2-carboxylate. And in the whole synthesis process, attention should be paid to the separation and purification steps after the reaction to obtain high-purity target products.

Ethyl 3,4-dimethylpyrrole-2-carboxylic acid ester, this substance is an organic compound with unique physical properties. Looking at its properties, it is often liquid at room temperature and pressure, colorless or slightly yellow, clear and transparent, like the quality of glaze, or faint luster in sunlight.
Its melting point is [X] ° C, which is like the critical point for water to form ice in cold winter. At this temperature, the state of matter changes. The boiling point is around [X] ° C, just like the boiling of water. At this high temperature, the liquid state will turn into gas. < Br >
In terms of solubility, in organic solvents such as ethanol and ether, it can be quietly dissolved, just like salt entering water, invisible, and fused with it, but it is extremely difficult to dissolve in water, just like oil floating in water, and the two are difficult to mix.
The density is about [X] g/cm ³, which is slightly lighter than water. If it is placed in one place with water, it is like wood floating in water, quietly above. In addition, it also has a certain degree of volatility. In the air, it is like a curl of blue smoke, which is slowly emitted, but the evaporation rate is not very fast. The scent was unique. Although it was not pungent, it was unique. The scent was impressive, just like the scent of some unique fragrance, which could be detected slightly in the air.

Ethyl 3,4-dimethylpyrrole-2-carboxylate is an organic compound, which has the following chemical properties:
First, it has the typical properties of an ester. Due to the presence of ester groups (-COOEt), hydrolysis can occur. Under acidic conditions, hydrolysis generates 3,4-dimethylpyrrole-2-carboxylate and ethanol. This reaction is reversible and goes through the steps of protonation, hydrophilic nucleophilic attack, and leaving group detachment. Under alkaline conditions, hydrolysis is more thorough, generating 3,4-dimethylpyrrole-2-carboxylate and ethanol. The process is irreversible, and the positive electricity of carbonyl carbons in alkali-assisted ester groups is enhanced, and water is more likely to attack. < Br >
Second, the properties of pyrrole rings. Pyrrole rings are aromatic, but their electron cloud density distribution is different from that of benzene rings. Nitrogen atoms contribute a pair of electrons to participate in conjugation, so the electron cloud density on the ring is relatively high. Therefore, electrophilic substitution reactions are prone to occur, and the substitution check points are mostly at the α position (ie, 2-position and 5-position), because the electron cloud density of the α position is higher than that of the β position. For example, when reacted with halogenated reagents, halogenated derivatives can be formed.
Third, the properties of methyl groups. Some reactions can occur between methyl groups at the 3-position and 4-position in the molecule. Methyl groups have the effect of pushing electrons, which can affect the electron cloud density distribution of pyrrole rings. And methyl groups can undergo oxidation reactions, such as under the action of suitable oxidants, they can be gradually oxidized to oxygen-containing functional groups such as carboxyl groups.
Fourth, the properties of nitrogen atoms. The nitrogen atom on the pyrrole ring has a certain alkalinity and can be combined with acids to form salts. However, due to the participation of lone pair electrons on the nitrogen atom in the conjugation system, its basicity is weaker than that of aliphatic amines.
Ethyl 3,4-dimethylpyrrole-2-carboxylate has many chemical properties, which make it valuable in the field of organic synthesis and can be used to construct a variety of complex compounds containing pyrrole structures.

Ethyl 3,4 - dimethylpyrrole - 2 - carboxylate is an organic compound, which is difficult to determine in the market price range. The price of this compound often varies due to many factors.
First, purity is the key factor. If the purity is very high, almost scientific research grade, up to 99% or more, the preparation of this product is not easy, it requires fine process and strict purification, and its price is high. Or ranging from tens to hundreds of yuan per gram.
Second, the purchase volume also has an impact. If it is a small amount of laboratory-grade procurement, the supplier may price it high due to transaction costs. However, if large-scale industrial procurement, the unit price may drop significantly due to economies of scale.
Third, the market supply and demand relationship also affects its price. If there is a sudden increase in demand and limited supply, if the demand for this compound in some drug development stages rises sharply, its price will rise; on the contrary, if there is an excess supply, the price will decline.
Fourth, different suppliers have different pricing strategies. Well-known large manufacturers, because of their good brand reputation, quality control and after-sales services, their prices may be higher than those of ordinary manufacturers.
In short, the price of Ethyl 3,4 - methdiylpyrrole - 2 - carboxylate varies from a few yuan per gram to hundreds of yuan per gram. It is difficult to generalize.