Ethyl 2,5-dimethylpyrrole-3-carboxylate

Ethyl 2,5-dimethylpyrrole-3-carboxylic acid ester is a class of organic compounds. It has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
First, in the field of pharmaceutical chemistry, this compound can participate in the construction of complex molecular structures with specific pharmacological activities through a series of reactions. In the process of many drug development, it is necessary to introduce specific functional groups through its unique chemical structure, and then modify and optimize the properties of drug molecules, such as improving the bioavailability of drugs and enhancing their affinity with targets.
Second, in the field of materials science, ethyl 2,5-dimethylpyrrole-3-carboxylate also has its uses. It can be polymerized or combined with other materials to prepare materials with special properties. For example, polymer materials with specific optical and electrical properties are synthesized for the manufacture of optoelectronic components, sensors and other devices.
Furthermore, in the total synthesis of natural products, this compound is often an important synthetic building block. Due to its structural characteristics, it can be skillfully embedded in the molecular structure of target natural products, helping to achieve the total synthesis of complex natural products, providing a material basis for the study of the biological activity and mechanism of action of natural products. From this perspective, ethyl 2,5-dimethylpyrrole-3-carboxylate plays an important role in many fields such as organic synthesis, drug development, materials science, and total synthesis of natural products, and has high research and application value.

There are several common methods for preparing ethyl 2,5-dimethylpyrrole-3-carboxylic acid esters.
First, a pyrrole ring can be constructed from a suitable starting material through a multi-step reaction. For example, a ketone with a suitable substituent group and an ammonia or amine compound undergo a condensation reaction under specific conditions. Take acetylacetone as an example. Under the catalysis of ammonia acid or base, it first condenses with ammonia to form an enamine intermediate, followed by cyclization, dehydration and other steps to construct a pyrrole ring. On this basis, the carboxylethyl ester group is introduced at a specific position of the pyrrole ring, which can be achieved by esterification. Select suitable alcohols and acylating reagents, such as ethanol and corresponding acyl halides or acid anhydrides, in the presence of a catalyst, to complete the esterification to obtain the target product ethyl 2,5-dimethylpyrrole-3-carboxylate.
Second, a compound containing pyrrole structure can also be used as a raw material and modified. If there is a pyrrole derivative, the substituent status is different from the target product, and the substituent can be changed by selective substitution reactions. For example, a specific position on the pyrrole ring is halogenated first, and then a nucleophilic substitution reaction is carried out to introduce methyl and carboxylethyl ester groups. With a suitable halogenating agent, the pyrrole ring is halogenated under specific conditions, and then a methylating agent, such as iodomethane and a base, is introduced into the methyl group; then through the carboxylation reaction, a carboxyl group is introduced, and then ethyl 2,5-dimethyl pyrrole-3-carboxylate is esterified.
During the preparation process, attention should be paid to the precise control of the reaction conditions, such as temperature, pH, reaction time, etc., which have a significant impact on the reaction process and the purity and yield of the product. At the same time, the purity of the raw materials used and the cleanliness of the reaction equipment cannot be ignored, so that ethyl 2,5-dimethyl pyrrole-3-carboxylate can be synthesized efficiently and with high quality.

Ethyl 2,5-dimethylpyrrole-3-carboxylate is an organic compound with the following physical properties:
It is a liquid and exists stably at room temperature and pressure. Due to the stable bonding of each atom in the molecular structure, it does not contain active functional groups that are easily decomposed or reactive. Looking at its appearance, it is colorless or slightly pigmented. If it contains trace impurities, it may have a very light color.
The compound has certain volatility, but it is not very volatile. Due to the existence of van der Waals force between molecules, this force restricts the molecule from escaping from the liquid phase into the gas phase, and the volatilization process is relatively slow.
In terms of solubility, it can be soluble in common organic solvents, such as ethanol, ether, dichloromethane, etc. This is because the molecule of the compound has a certain hydrophobicity, and it can form a similar dissolving force with the molecules of organic solvents. However, it is difficult to dissolve in water, because the overall non-polarity of its molecules is strong, and it cannot form effective interactions with water molecules, such as hydrogen bonds. The melting point and boiling point of
Ethyl 2,5-dimethylpyrrole-3-carboxylate are also important physical properties. Its melting point is low, and it is liquid at room temperature, which is closely related to the molecular structure. The intermolecular force is not enough to fix the molecule into a solid lattice at room temperature. The boiling point is in a specific range, and the specific value is affected by factors such as molecular weight and intermolecular force. The molecular weight and intermolecular force jointly determine the energy required for gasification, thereby determining the boiling point.

Ethyl-2,5-dimethylpyrrole-3-carboxylic acid ester, this is an organic compound. Its chemical properties are unique and valuable to explore.
From the perspective of physical properties, the compound is liquid or solid at room temperature, but the exact state varies according to its specific structure and environmental conditions. Its melting point, boiling point are closely related to the intermolecular forces, and the chemical bonds and spatial structures within the molecule also affect its physical properties.
In terms of chemical properties, the compound contains pyrrole rings and ester groups, which give it a variety of reactivity. The ester group can undergo hydrolysis and react with water in an acidic or alkaline environment to form corresponding carboxylic acids and alcohols. Under alkaline conditions, the hydrolysis process may be more rapid and complete.
The pyrrole ring is aromatic and can participate in electrophilic substitution reactions. In view of the electron cloud distribution on the pyrrole ring, the substitution reaction may mainly occur at a specific location. For example, when reacting with halogenated reagents, halogenated derivatives can be formed.
At the same time, because of the presence of methyl groups in the molecule, methyl groups can undergo oxidation and other reactions under specific conditions. The conjugated structure of the compound also affects its chemical activity and spectral properties. This conjugated system may cause it to have unique absorption in the ultraviolet-visible spectral region, providing assistance for its analysis and identification. In addition, it can be used as a key intermediate in the field of organic synthesis to build more complex organic molecular structures through a series of reactions.

I look at your question, but I am inquiring about the price range of ethyl 2,5-dimethylpyrrole-3-carboxylate in the market. However, the price of this compound is difficult to determine, because many factors can control it.
First, purity is the key. If the purity is extremely high and nearly flawless, such as more than 99%, its price will be high. The preparation of high purity requires exquisite craftsmanship and complicated processes, which consume huge manpower, material resources and financial resources. If the purity is slightly lower, between 90% and 95%, the price will drop. Due to slightly more impurities, it may affect its effect on specific reactions or applications.
Second, the purchase quantity also has an impact. If it is a small quantity, such as the need for laboratory research, a few grams to tens of grams, the supplier may have a higher unit price due to cost considerations such as packaging and transportation. If it is purchased in bulk, up to kilograms or even tons, the unit cost will be reduced based on economies of scale, and the price will also drop significantly.
Third, the market supply and demand relationship should not be underestimated. If the demand for this product is strong and the supply is limited, it is like a rare treasure, and the price will rise. On the contrary, if the supply exceeds the demand, the merchant may reduce the price in order to sell the inventory.
Fourth, the pricing of different suppliers is also different. Well-known large factories are famous for their quality and reputation, and their product prices may be high. And some emerging or small suppliers may be more affordable in order to compete for market share.
In summary, under common market conditions, the price per gram of ethyl 2,5-dimethylpyrrole-3-carboxylate with small quantities and high purity (about 98%) may range from tens to hundreds of yuan. If purchased in large quantities and with moderate purity (about 95%), the price per kilogram may range from several thousand yuan. However, this is only a rough estimate, and the actual price can only be determined by consulting the supplier in detail.