Ethyl-1- (4-fluorobenzyl) -2-methyl -1H- pyrrole-3-carboxylate

Ethyl-1- (4-fluorobenzyl) -2 -methyl-1H-pyrrole-3-carboxylate, Chinese name ethyl-1- (4-fluorobenzyl) -2-methyl-1H-pyrrole-3-carboxylate, this compound is widely used in medicine, chemical industry and other fields.
In pharmaceutical research and development, it may be a key intermediate and can participate in the construction of a variety of drug molecules. For example, some new anti-tumor drugs are designed and synthesized with it as a starting material, and specific functional groups are introduced through multi-step reactions to construct structures with targeted tumor cell activity. Due to the structure of pyrrole ring and fluorobenzyl group, the compound has unique physicochemical and biological activities, which can optimize the binding ability of drugs to tumor cell targets and enhance the curative effect.
In the field of chemical materials, it can be used as an important building block for the synthesis of functional materials. By virtue of its own structural properties, it can be polymerized or modified with other monomers to prepare polymer materials with special properties. For example, materials with specific optical and electrical properties are synthesized for optical display, electronic device manufacturing, such as organic Light Emitting Diode (OLED) materials, or its introduction improves luminous efficiency and stability.
It is also used in organic synthesis research to explore new reaction paths and methods as model compounds. Chemists use its unique structure to study reaction mechanisms, develop new catalytic reactions or conversion strategies, promote the development of organic synthesis chemistry, and provide new ideas and methods for the synthesis of more complex compounds, which is of great significance in the synthesis of innovative drugs and functional materials.

Ethyl - 1 - (4 - fluorobenzyl) - 2 - methyl - 1H - pyrrole - 3 - carboxylate is an organic compound, and its physical properties are worthy of in-depth investigation.
Looking at its properties, it is mostly white to light yellow crystalline powder under normal conditions, which is conducive to its participation in reactions in many reaction systems, and the powder shape also gives it a large specific surface area, which in turn affects its solubility and reactivity.
Talking about solubility, the compound exhibits unique properties in organic solvents. In common organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), it has good solubility. Halogenated hydrocarbon solvents such as dichloromethane and chloroform can achieve good compatibility with Ethyl-1- (4-fluorobenzyl) -2-methyl-1H-pyrrole-3-carboxylate molecules through van der Waals force, dipole-dipole interaction, etc. This property makes halogenated hydrocarbon solvents a good choice when they need to react in a homogeneous system in organic synthesis. As a strong polar aprotic solvent, the carbonyl group and nitrogen atom in the molecular structure of DMF can interact with the target compound to form hydrogen bonds, which can also effectively dissolve the substance. However, its solubility in water is very small, because the hydrophobic group accounts for a large proportion of the compound molecule, and it is difficult to form an effective interaction with water molecules, resulting in its insolubility in water.
In terms of melting point, the compound has a relatively clear melting point range, about [specific melting point range], and the determination of melting point is crucial for its purity identification. If the sample purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point is often reduced and the melting range is widened. This property is of great significance in the purification and quality control of compounds. < Br >
In addition, its density is also one of the important physical properties. Under specific conditions, the density is [specific density value]. This parameter plays a key role in the quantitative reaction, solution preparation, and phase separation of the compound. It is indispensable for the precise control of the reaction process and the proportion of the product.

There are several common methods for synthesizing Ethyl-1- (4-fluorobenzyl) -2-methyl-1H-pyrrole-3-carboxylate. First, it can be obtained from a suitable starting material through a multi-step reaction. First, take the fluorinated benzyl halide and react with the methyl pyrrole derivative to form the intermediate 1- (4-fluorobenzyl) -2-methyl-1H-pyrrole. This reaction often requires the catalysis of alkali substances, such as potassium carbonate, sodium carbonate, etc., in suitable organic solvents, such as acetonitrile, N, N-dimethylformamide. Organic solvents can help the starting material to be miscible and promote the reaction. The base then captures the hydrogen of the pyrrole derivative, making it nucleophilic, and then reacts with the benzyl halide for nucleophilic substitution. < Br >
After the intermediate is obtained, an esterification reaction is carried out to introduce ethyl ester groups. Usually ethanol and suitable esterification reagents, such as thionyl chloride and oxalyl chloride, are used to convert carboxylic acids into acid chlorides, and then react with ethanol to form esters. Condensers such as DCC (dicyclohexyl carbodiimide) can also be used to esterify directly with ethanol. This step requires controlling the reaction conditions, such as temperature, reaction time and reagent dosage, to obtain a high-purity Ethyl-1- (4-fluorobenzyl) -2-methyl-1H-pyrrole-3-carboxylate product.
Another way can be designed to synthesize in one pot. Select suitable starting materials, and in the same reaction vessel, through clever regulation of reaction conditions and reagent addition order, continuous multi-step reactions can be carried out. This can reduce the intermediate separation steps, improve the reaction efficiency and reduce the cost. However, the one-pot method requires more stringent reaction conditions, and the reaction process of each step needs to be precisely controlled to avoid side reactions and affect the purity and yield of the product. In short, the synthesis of this compound requires careful selection of appropriate synthesis methods according to actual conditions and needs, and fine optimization of reaction conditions.

Look at this "Ethyl - 1 - (4 - fluorobenzyl) - 2 - methyl - 1H - pyrrole - 3 - carboxylate", which is an organic compound, or "1 - (4 - fluorobenzyl) - 2 - methyl - 1H - pyrrole - 3 - carboxylate" in Chinese. It is not easy to know its market price. The price of organic compounds often varies due to many factors.
First, purity is the key. If this compound has extremely high purity and is close to reagent grade, it can be used in high-end fields such as fine chemical experiments and pharmaceutical research and development, and its price is high. However, if the purity is slightly lower, it is only suitable for general industrial synthesis, and the price should drop.
Second, the market supply and demand have a great impact. If the pharmaceutical industry is enthusiastic about the research and development of drugs containing this structure, the demand surges, and the supply is limited, the price will rise. On the contrary, if the market demand is weak, and there are many manufacturers and excess supply, the price will fall.
Third, the production process and cost also affect the price. If the preparation of this compound requires complicated processes, expensive raw materials or special equipment, and the cost is high, the price in the market will also be high.
However, the exact market price of this compound was not obtained after searching the classics. Or due to the rapidly changing market, and different suppliers, different purchase quantities, prices are different. For more information, you can get more accurate price information by consulting chemical raw material suppliers, chemical reagent sellers, or professional chemical trading platforms.

Ethyl - 1 - (4 - fluorobenzyl) - 2 - methyl - 1H - pyrrole - 3 - carboxylate is also an organic compound. Its safety is related to many aspects, let me tell you one by one.
On the side of toxicity, there is no detailed and exact conclusion. However, compounds of the same structure may have certain toxicity. If ingested inadvertently, it may damage the digestive system of the human body, causing nausea, vomiting, abdominal pain, etc. This is because after the compound enters the human body, it may interfere with the normal physiological function of the digestive system, affecting the activity of digestive enzymes and the peristalsis of the gastrointestinal tract.
If the skin comes into contact with it, there is also a risk. Or cause allergic reactions in the skin, such as erythema, itching, swelling, etc. Because the substance may stimulate the immune system of the skin, it causes abnormal activation of immune cells, which in turn produces such allergic symptoms.
As for the situation of inhalation, if the compound forms aerosols or dust during production or use, it may be inhaled by people, which may irritate the respiratory tract. In mild cases, it may cause cough, runny nose, and in severe cases, it may cause inflammation of the respiratory tract, affecting the gas exchange function of the lungs.
In terms of environmental safety, if this compound enters the natural environment, its degradation process is very critical. In soil, it may be decomposed by microorganisms, but its decomposition rate and final product are still unknown. If the decomposition is slow, or accumulated in the soil, it will affect the ecological structure and function of the soil, and may also have a negative effect on the growth of plants.
In the aquatic environment, its solubility and impact on aquatic organisms also need to be considered. Or affect the survival and reproduction of aquatic organisms, and interfere with the balance of aquatic ecosystems.
Therefore, when using and disposing of Ethyl - 1 - (4 - fluorobenzyl) - 2 - methyl - 1H - pyrrole - 3 - carboxylate, be cautious and follow relevant safety procedures to ensure human health and environmental safety.