5-(ethoxycarbonyl)-1H-pyrrole-2-carboxylic acid

5- (ethoxycarbonyl) -1H-pyrrole-2-carboxylic acid, this is an organic compound. Looking at its name, it can be seen that its structure is based on a pyrrole ring. Pyrrole ring is a nitrogen-containing five-membered heterocyclic ring with aromatic properties. At the 2nd and 5th positions of 1H-pyrrole, there are specific groups connected respectively.
The first word is 2 positions, which are connected with a carboxyl group (-COOH). This carboxylic group is the logo of an organic carboxylic acid, which is acidic and can participate in many chemical reactions, such as salt formation, esterification, etc. At the 5th position, there is an ethoxycarbonyl group (- COOCH -2 CH
), which is composed of a carbonyl group (- CO -) connected to an ethoxy group (- OCH ³ CH <). Carbonyl groups have certain electrophilicity, and ethoxy groups can affect the electron cloud distribution and spatial structure of molecules.
The presence of ethoxycarbonyl gives molecules specific chemical properties and reactivity. It can participate in ester-related reactions, such as hydrolysis to form carboxylic acids and alcohols, and alcoholysis to form new esters. Carboxyl groups and ethoxycarbonyl groups coexist in the same molecule, and the two interact with each other, which enriches the chemical behavior of the compound. Or through appropriate reaction conditions, the selective conversion of the two can be achieved to prepare a series of derivatives, which have potential application value in the field of organic synthesis.

5- (ethoxycarbonyl) -1H-pyrrole-2-carboxylic acid, this compound has a wide range of uses. In the field of pharmaceutical synthesis, it is often used as a key intermediate. In the creation process of many drugs, it plays a role that cannot be ignored. For example, when developing heterocyclic drugs with specific physiological activities, the compound can undergo a series of chemical reactions to ingeniously build the core skeleton of the drug and help synthesize drugs with precise curative effects.
In the field of materials science, it also shows unique value. Due to its structural properties, it can participate in the preparation of some functional materials. For example, it is used to synthesize polymer materials with special optical or electrical properties, imparting novel properties to materials and meeting the special needs of material properties in different scenarios.
In the field of organic synthetic chemistry, as an important synthetic block, it can react with a variety of reagents to derive organic compounds with diverse structures. Chemists can carefully design synthetic routes according to their reactivity and selectivity to achieve efficient construction of complex organic molecules, greatly promoting the development and progress of organic synthetic chemistry, providing rich raw materials and possibilities for the creation and research of new substances.

The synthesis of 5- (ethoxycarbonyl) -1H-pyrrole-2-carboxylic acids is an important research in the field of chemical synthesis. There are many synthesis paths, and the following are some common methods described in detail.
One of them can be obtained by the functional group conversion of pyrrole derivatives. Pyrrole with suitable substituents is used as the starting material, and its specific position is modified first. For example, by introducing the corresponding substituent on the pyrrole ring, and then using the esterification reaction, the ethoxycarbonyl is introduced to the target position, thereby achieving the synthesis of 5- (ethoxycarbonyl) -1H-pyrrole-2-carboxylic acid. This process requires precise control of reaction conditions, such as temperature, reaction time, and the proportion of reactants, in order to achieve the ideal yield and purity.
Second, it can also be synthesized by means of cyclization. Select the appropriate chain compound, under the specific catalyst and reaction conditions, make it undergo intramolecular cyclization to form a pyrrole ring structure. At the same time, during or after cyclization, ethoxycarbonyl and carboxyl groups are introduced through appropriate reaction steps. The key to this method is the design of the chain reactants and the optimization of cyclization reaction conditions to ensure the correct pyrrole ring substitution mode.
Third, there is a strategy to use transition metal catalysis for the reaction. Transition metal catalysts can effectively promote the formation and fracture of various chemical bonds. In the synthesis of 5- (ethoxycarbonyl) -1H-pyrrole-2-carboxylic acids, transition metal catalysis can be used to achieve the construction of pyrrole rings and the introduction of ethoxycarbonyl and carboxyl groups. This method usually has the advantages of high reaction efficiency and good selectivity, but the selection and use conditions of catalysts are more stringent.
Each synthesis method has its advantages and disadvantages. In practical application, the most suitable synthesis path should be selected according to specific requirements, such as cost, yield, purity, and operability of reaction conditions.

5- (ethoxycarbonyl) -1H-pyrrole-2-carboxylic acid has unique physical and chemical properties. It is a solid, mostly white or off-white crystalline under normal conditions, and its texture is fine.
When it comes to the melting point, it is about a specific temperature range. This property is quite useful in identification and purification. The determination of the melting point can determine the purity. In terms of solubility, it has a certain solubility in common organic solvents such as ethanol and acetone, but its solubility in water is limited. This solubility property provides a variety of possibilities for its application in different reaction systems and separation processes.
Its chemical properties are active, and both the intracellular carboxyl group and the ethoxycarbonyl group are reactive. The carboxyl group can be neutralized with bases to form corresponding carboxylic salts; it can also be esterified with alcohols under acid catalysis to derive different ester compounds. Ethoxycarbonyl can also participate in a variety of reactions, such as hydrolysis. Under acid or base catalysis, ethoxycarbonyl can be hydrolyzed to carboxyl groups. This reaction is often used in organic synthesis to construct compounds with specific structures. In addition, the hydrogen atom on the pyrrole ring can be replaced by other groups under appropriate conditions, further enriching its chemical derivation path, laying the foundation for the creation of complex organic compounds with specific functions.

The price of 5- (ethoxycarbonyl) -1H-pyrrole-2-carboxylic acid is determined in Wuwei City, and its price varies due to many reasons. This compound is used differently, with different sources, different quality, and different quantities, all resulting in different valences.
If it is used for scientific research, the price of a small amount of high purity is high. Because of its fine process, strict control of impurities, and purity of properties, in order to meet the requirements of scientific research. However, its use is small, mostly in the milligram level. Although the price is high, the overall cost may be affordable.
For industrial users, there is a large demand, and the price may be relatively flat. Due to the large scale of industrial production, the unit cost can be reduced. However, the quality requirements or different scientific research, the price varies depending on the quality. < Br >
The way to buy is also the price. Purchased from well-known reagent suppliers, although the quality is high and reliable, the price may be high; from emerging suppliers, there may be discounts, but the stability of the quality needs to be observed.
In addition, the supply and demand of the city also affect its price. If you ask for more and less, the price will rise; if the supply exceeds the demand, the price may fall.
To know the exact price, you should consult the reagent supplier, chemical raw material supplier, and provide detailed information on the required quantity and quality.