5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, which is one of the organic compounds. Its chemical structure is quite unique.
Looking at its structure, the No. 5 position is connected with a benzoyl group. This benzoyl group is composed of a benzene ring connected to a carbonyl group. The benzene ring has a conjugated system, which endows the compound with a specific electronic effect and spatial structure. The 2,3-dihydro-1H-pyrrolizine part is a heterocyclic structure containing nitrogen, and the pyrrolizine ring has certain rigidity and stability. 1-Carboxylic acid indicates the presence of a carboxyl group at position 1, which is acidic and can participate in many chemical reactions, such as salt formation, esterification, etc.
The structure of this compound affects each other, and the electronic effect of benzoyl groups can affect the electron cloud density of pyrrolizine ring, which in turn affects its reactivity; the presence of carboxyl groups also makes the compound exhibit unique chemical reactions and physical properties. In summary, the chemical structure of 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, and the interaction of each group, jointly determine its chemical and physical properties.

5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid is one of the organic compounds. Its physical properties are of great research value.
Looking at its appearance, it is often a crystalline solid. Due to the intermolecular force, the molecules are arranged in an orderly manner to form a crystalline structure. Under normal temperature and pressure, it is quite stable, but its structure may change under high temperature or specific chemical environment.
When it comes to the melting point, it has been determined by many experiments that it is within a specific temperature range. This temperature range is the critical temperature for the compound to change from solid to liquid. The value of the melting point is of great significance for its application in various chemical reactions and material preparation. The reaction conditions can be adjusted accordingly to ensure that it is in a suitable physical state.
In terms of solubility, this compound exhibits a certain solubility in organic solvents such as ethanol and acetone. Because the molecules of organic solvents can form interactions such as hydrogen bonds and van der Waals forces with the molecules of the compound, it can be dispersed in the solvent. However, in water, its solubility is relatively limited. Due to the weak interaction between water molecules and the molecules of the compound, it is difficult to overcome the cohesion between the molecules of the compound.
In addition, the density of the compound is also one of its important physical properties. Its density reflects the mass of the substance contained in a unit volume, and plays a key role in accurate measurement and proportioning in chemical production and drug development.
As for its color, it is often colorless or slightly yellowish in its pure state. This color feature can also be used as a preliminary judgment of its purity.
In summary, the physical properties of 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acids, such as appearance, melting point, solubility, density, and color, are of great value in chemical research, materials science, and related industries, providing a foundation for in-depth exploration of their chemical properties and applications.

5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, this is an organic compound. In the field of modern chemistry, its uses are quite extensive.
First, in the field of pharmaceutical chemistry, it may be used as a key intermediate for the creation of new drugs. Because of its unique structure or specific biological activity, chemists can modify and modify its structure to search for compounds with better pharmacological properties. For example, by functionalizing its benzoyl group or pyrrolizine ring, it may enhance its affinity with specific biological targets, thereby improving its efficacy or reducing its toxic and side effects.
Second, in the field of materials science, this compound also shows potential application value. Because of its certain stability and special electronic structure, it can be used to prepare functional materials. For example, by specific synthesis methods, it is introduced into polymer materials to endow the materials with unique optical, electrical or mechanical properties, opening up new paths for the development of materials science.
Third, in the field of organic synthetic chemistry, as an important synthetic block, 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid can participate in a variety of organic reactions and construct more complex organic molecular structures. Chemists can use its carboxyl group to react with other active hydrogen or nucleophilic reagents to achieve the construction of carbon-carbon bonds or carbon-hetero bonds, thereby enriching the variety and structural diversity of organic compounds.

The method of synthesizing 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid has been used in ancient times, and there are many methods.
First, the benzoylation reaction can be carried out with benzoyl reagent starting from suitable pyrrolizine derivatives. Select benzoyl halides with suitable activity, such as benzoyl chloride, in an alkaline environment, and blend with pyrrolizine derivatives. For bases, choose triethylamine and pyridine, which can create a suitable reaction atmosphere without unduly interfering with the reaction process. The two are gently heated in organic solvents, such as dichloromethane and chloroform, and react slowly. The properties of organic solvents are related to the reaction rate and product purity, and the choice should be careful. In this process, the benzoyl group of benzoyl halide, electrophilic attacks the specific check point of pyrrolizine derivatives, and then becomes 5-benzoyl-2,3-dihydro-1H-pyrrolizine-intermediate, and then through subsequent steps such as hydrolysis, the target 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid can be obtained.
Second, to construct the strategy of pyrrolizine ring. It can be formed from nitrogen-containing and carbon-containing raw materials through multi-step cyclization reaction. First, a specific amine and carbonyl compound are condensed under acid or base catalysis to construct a preliminary skeleton. Then, under suitable conditions, benzoyl groups are introduced. If the analogs of 2,3-dihydro-1H-pyrrolizine-1-carboxylic acid are first prepared, and then benzoylated, the goal can also be achieved. This approach requires precise control of the reaction conditions of each step. Temperature, catalyst dosage, reaction time, etc. are all key. A slight difference in the pool will lead to impure products or low yields.
Third, the reaction may be catalyzed by transition metals. For example, metals such as palladium and copper are used as catalysts to couple ligands containing benzoyl groups with pyrrolizine-related substrates. The activity and selectivity of metal catalysts are crucial. The structure of ligands also needs to be carefully investigated. Its coordination ability with metals affects the activity and direction of the reaction. Under the protection of inert gas, the reaction temperature and time are controlled to prompt the reaction to proceed according to the expected path to obtain 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid.
All these methods have their own advantages and disadvantages. When actually synthesizing, it is necessary to make a careful choice based on factors such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product.

I am not sure whether "5 - benzoyl - 2,3 - dihydro - 1H - pyrrolizine - 1 - carboxylic acid" is in the market price range. This is a relatively professional chemical substance, and its price is influenced by many factors.
First, the purity has a great impact. For high purity, the preparation is difficult and the process is complicated, so the price is high; for low purity, the preparation is slightly easier, and the price may be lower.
Second, the relationship between supply and demand is also the key. If the market demand for it is strong and the supply is limited, the price must be high; if the demand is weak and the supply is sufficient, the price may be low.
Third, the manufacturer and the source are different. Different manufacturers have different technologies and costs, resulting in different prices. Imported products may have different prices than domestic products due to factors such as transportation and tariffs.
Fourth, the purchase volume also has an impact. Buy in bulk, or due to scale effect, get preferential prices; buy in small amounts, unit price or high.
For the exact price range, you can consult chemical product suppliers, chemical reagent sales platforms, or at relevant industry exhibitions and forums, and inquire from industry insiders to get an accurate price range.