5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde

5- (2-furyl) -1H-pyrrole-3-ethyl acetate, this is an organic compound with unique chemical properties. Its properties can be viewed from the following aspects:
1. ** Physical properties **: At room temperature, or in a liquid or low-melting point solid state, due to the arrangement and interaction of atoms and groups in the molecule. It has good solubility in organic solvents, such as common ethanol, ether, chloroform, etc., which can form suitable interaction forces between molecular structure and organic solvents, such as van der Waals force, hydrogen bond, etc.
2. ** Chemical properties **:
- ** Acidic **: In its structure, the α-hydrogen atom is acidic due to the influence of pyrrole ring and furan group. In a strong alkali environment, α-hydrogen is easily captured by bases and generates carbon negative ions. This carbon negative ion has high activity and can participate in a series of nucleophilic substitution reactions. For example, when it encounters halogenated hydrocarbons, nucleophilic substitution can occur, and novel compounds can be derived, thereby expanding the structural diversity of compounds.
- ** Nucleophilic Reaction **: The carbonyl group in the molecule is an electrophilic center and is vulnerable to attack by nucleophilic reagents. Like alcohols, under the catalysis of acids or bases, nucleophilic addition-elimination reactions can occur with carbonyl groups to form transesterification products. Or react with ammonia and amine nucleophiles to form amide derivatives, which is of great significance in the preparation of nitrogen-containing compounds in organic synthesis.
- ** Conjugated system-related reactions **: Furan groups and pyrrole rings build a conjugated system, giving molecules a unique electron cloud distribution. This makes the compound sensitive to electrophilic reagents and can undergo electrophilic substitution reactions. Taking halogenation as an example, under specific conditions, halogen atoms will selectively replace hydrogen atoms at positions with higher electron cloud density on the conjugated system to realize the functionalization of compounds, laying the foundation for the synthesis of more complex organic compounds. < Br > - ** Ester Properties **: As an ester compound, 5- (2-furyl) -1H-pyrrole-3-ethyl acetate can be hydrolyzed under acid or base catalysis. In acidic hydrolysis, corresponding carboxylic acids and alcohols are formed; in basic hydrolysis, carboxylic salts and alcohols are formed. This property is widely used in functional group conversion and product separation and purification in organic synthesis.

To prepare 5- (2-furyl) -1H-pyrazole-3-ethyl acetate, the common synthesis methods are as follows:
First, furanaldehyde is used as the starting material. First, furanaldehyde and compounds with active methylene groups are condensed under the action of basic catalysts to obtain α, β-unsaturated carbonyl compounds containing furanyl groups. This process requires controlling the reaction temperature and catalyst dosage to avoid side reactions. After that, the unsaturated carbonyl compound reacts with hydrazine compounds to cyclize to form 5- (2-furanyl) -1H-pyrazole compounds. Finally, the pyrazole product is reacted with halogenated ethyl acetate under basic conditions, and ethyl acetate is introduced through nucleophilic substitution to obtain the target product. The raw materials of this route are often available, but there are many steps, and the reaction conditions of each step need to be carefully controlled to improve the yield.
Second, 2-methylfuran is used as the starting material. Appropriate functionalization of 2-methylfuran is first carried out, such as halogenation reaction, and halogen atoms are introduced to facilitate subsequent reactions. Afterwards, it is reacted with nitrogen-containing nucleophiles to construct a pyrazole ring. After a suitable esterification reaction, the carboxyl group is converted into ethyl acetate group. This approach is relatively streamlined, but the functionalization selectivity of 2-methylfuran needs to be carefully regulated, otherwise impurities are easy to form. < Br >
Or microwave-assisted synthesis can be used. This method is based on the conventional synthesis route and uses microwave radiation to promote the reaction. Rapid microwave heating can make molecules vibrate and collide rapidly, accelerate the reaction rate, and improve some reaction selectivity. However, special microwave equipment is required, which requires stricter requirements for the reaction system.
In addition, solid-phase synthesis is also used. The reactants are immobilized on the solid-phase support. After the reaction is completed, the products are separated by simple filtration, washing and other operations. This method is convenient for product separation and purification, which can reduce side reactions and improve product purity. Only the selection of solid-phase support and immobilization steps need to be carefully designed.

5- (2-furyl) -1H-pyrazole-3-acetic acid is an organic compound. It has applications in many fields such as pharmaceutical research and development, agricultural chemistry and materials science.
In the field of pharmaceutical research and development, this compound exhibits potential biological activity. Studies have shown that it may have positive effects on the treatment of specific diseases. For example, some studies have focused on its anti-inflammatory properties, which may provide new opportunities for the treatment of inflammatory diseases by modulating inflammation-related signaling pathways in the body and reducing inflammatory responses. Furthermore, in anti-tumor research, the compound has also come to the fore, and may exert anti-tumor activity by interfering with the growth, proliferation and metastasis mechanism of tumor cells, contributing to the development of anti-tumor drugs.
In the field of agricultural chemistry, 5- (2-furyl) -1H-pyrazole-3-acetic acid also has important applications. It may be used as an active ingredient of new pesticides to achieve efficient pest control with its unique mechanism of action against certain pests. If it affects the nervous system or growth and development process of specific insects, inhibits the reproduction and invasion ability of pests, and is more selective and environmentally friendly than traditional pesticides, it can ensure the yield and quality of crops while reducing the negative impact on the environment.
In the field of materials science, this compound can be used to synthesize special functional materials. Due to its own structural properties, it may endow materials with unique optical, electrical or mechanical properties. For example, when preparing optical materials, it can adjust the material's luminous properties, making it have application potential in optoelectronic devices such as organic Light Emitting Diode (OLED), providing a new direction for the development of new functional materials.

5- (2-furyl) -1H-pyrazole-3-methyl acetate is a fine chemical in the field of organic chemistry. Its market price often fluctuates due to multiple factors, and it is difficult to generalize. The following is your analysis.
First, the difficulty of the production process has a great impact. If the production of this compound requires complicated steps, harsh reaction conditions or special catalysts, the production cost will be high, and the market price will also rise. For example, it needs to be reacted in an ultra-low temperature or high pressure environment, or the use of rare and expensive catalysts, the price is naturally high.
Second, the supply of raw materials is also critical. If the raw materials required for the preparation of the substance are scarce, or the production of raw materials is restricted by factors such as seasons and regions, the price of raw materials will fluctuate, which will affect the price of finished products. If a key raw material is only produced in a specific region and at a specific time, and the supply is insufficient, the price will rise.
Third, the amount of market demand determines the price. If this compound is widely used in medicine, pesticides, materials science and other fields, the demand is strong, and the supply is relatively insufficient, the price will rise; on the contrary, if the demand is low, the price will also be suppressed. If the demand for new drugs increases greatly, the price will rise when the supply exceeds the demand.
Fourth, the market competition situation should not be underestimated. There are many manufacturers and fierce competition. In order to compete for market share, manufacturers may lower prices; conversely, if the market is almost monopolized, prices may be controlled by a few manufacturers.
According to market conditions, the price of 5- (2-furyl) -1H-pyrazole-3-methyl acetate per gram may range from tens to hundreds of yuan. The specific needs to be determined according to the above factors and real-time market conditions.

The storage conditions of 5- (2-furyl) -1H-pyrazole-3-ethyl acetate are related to the maintenance of its quality and utility. This substance should be stored in a cool, dry and well-ventilated place.
In a cool place, the temperature should not be too high. High temperature can easily cause its components to decompose and deteriorate, so it is better not to exceed 25 ° C. This temperature can make the molecule move moderately, and it will not cause structural variation due to heat.
A dry environment is indispensable, and moisture can easily cause chemical reactions such as deliquescence or hydrolysis, which will damage its purity and activity. The relative humidity should be controlled between 40% and 60%, so as to avoid damage due to moisture.
Well ventilated to avoid the accumulation of harmful gases. If there is a peculiar smell or harmful gas in the environment, or it is adsorbed by it, it will affect the quality. And ventilation can make the ambient temperature and humidity uniform, which is conducive to stable storage.
At the same time, it should be kept away from fire sources, heat sources and strong oxidants. Fire sources and heat sources are easy to heat up, and strong oxidants can react with them, which endangers the stability of this substance. It must be sealed and stored to avoid excessive contact with the air, so as to prevent the ingredients from being oxidized or reacting with the components in the air.
In summary, following these storage conditions, 5- (2-furyl) -1H-pyrazole-3-ethyl acetate can be guaranteed to maintain good quality and performance for a certain period of time.