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What is the chemical structure of 4H-thieno [3,2-b] pyrrole-5-carboxylic acid?
4H-pyrrolido [3,2-b] pyridine-5-carboxylic acid has a complex and delicate chemical structure. This compound contains the structure of the fused pyrrole and pyridine, and the pyrrolido [3,2-b] pyridine part is its core structure.
The pyrrole ring fuses with the pyridine ring in a specific [3,2-b] way to form a unique bilicyclic system. In this system, the nitrogen atom of the pyrrole ring participates in the formation of the ring, which has a great influence on the electron cloud distribution and chemical properties of the overall structure. The pyridine ring also has unique electronic properties, and the combination of the two makes the core structure exhibit special physical and chemical properties.
And the 5-carboxylic acid part is the chemical structure of the compound at the 5 position to connect a carboxyl group (-COOH). The carboxylic group is acidic and can participate in a variety of chemical reactions, such as salt formation reactions, esterification reactions, etc. Its presence significantly changes the polarity and hydrophilicity of the molecule, which in turn affects the solubility of the compound in different solvents and the interaction with other molecules.
Overall, the chemical structure of 4H-pyrrolido [3,2-b] pyridine-5-carboxylic acid fuses the special structure of pyrrolido-pyridine and the chemical activity of carboxyl groups, endowing it with unique chemical properties and may have important research value and application potential in the fields of organic synthesis, medicinal chemistry, etc.
What are the main uses of 4H-thieno [3,2-b] pyrrole-5-carboxylic acid?
4H-pyrrolido [3,2-b] pyridine-5-carboxylic acid is an important organic compound with critical uses in many fields.
In the field of medicinal chemistry, it can be used as a key intermediate for the synthesis of a variety of biologically active drug molecules. The fused structure of pyridine and pyrrole gives the compound unique physicochemical properties and biological activities, which can specifically bind to targets in organisms, such as certain enzymes or receptors. For example, anticancer drugs based on this structure can be designed and synthesized to inhibit cancer cell proliferation and induce apoptosis by precisely acting on specific targets of cancer cells, so as to achieve the purpose of treating cancer; or to develop drugs for neurological diseases, regulate neurotransmitter transmission, and relieve related symptoms.
In the field of materials science, 4H-pyrrolido [3,2-b] pyridine-5-carboxylic acids can participate in the preparation of functional materials. Because its structure contains heteroatoms such as nitrogen and oxygen, it can coordinate with metal ions to form complexes, which can be used in luminescent materials, sensor materials, etc. Taking luminescent materials as an example, by rationally designing molecular structures and adjusting their luminescent properties, high-efficiency luminescent organometallic complexes can be prepared, which can be used in organic Light Emitting Diode (OLED) and other fields to improve the performance of display technology; as sensor materials, it can be used to selectively interact with specific substances to achieve highly sensitive detection of harmful substances or biomolecules in the environment.
In the field of organic synthetic chemistry, this compound is an important synthetic building block and participates in the construction of many complex organic molecules. With its unique reactivity, it can introduce different functional groups through various organic reactions, such as nucleophilic substitution, electrophilic substitution, cyclization reaction, etc., to expand the diversity of molecular structures, providing rich synthesis strategies for organic synthesis chemists, assisting in the synthesis of organic compounds with specific structures and functions, and promoting the development of organic synthesis chemistry.
What are the synthesis methods of 4H-thieno [3,2-b] pyrrole-5-carboxylic acid?
There are several common methods for the synthesis of 4H-pyrrolido [3,2-b] pyridine-5-carboxylic acid:
First, a simple compound containing pyridine and pyrrole structures is used as the starting material, and the target molecule is constructed by a series of organic reactions. For example, with suitable pyridine derivatives and pyrrole derivatives, under suitable catalyst and reaction conditions, key carbon-carbon bonds and carbon-nitrogen bonds are formed through condensation reaction. This process requires precise control of reaction conditions, such as temperature, pH and reaction time, because these factors have a significant impact on reaction selectivity and yield.
Second, the synthesis path using transition metal catalysis. Transition metal catalysts such as palladium and copper can efficiently catalyze the coupling reaction of various substrates. For example, the Suzuki-Miyaura coupling reaction between halogenated pyridine and pyrrole-containing borate esters or other nucleophiles is carried out under palladium catalysis to form a pyrrolido [3,2-b] pyridine skeleton, which is then converted by appropriate functional groups to obtain the target 5-carboxylic acid product. This method has the advantages of high reactivity and good selectivity, but the catalyst cost is high and the reaction system is strict.
Third, it is synthesized by the strategy of intramolecular cyclization. First, linear precursors containing functional groups that can undergo intramolecular cyclization reactions are prepared, such as compounds containing suitable carbon-carbon double bonds, carbon-nitrogen double bonds and carboxyl groups. Under specific reaction conditions, intramolecular cyclization reactions occur to form pyrrolido [3,2-b] pyridine parent nuclei, and then the carboxyl group positions are modified to obtain 4H-pyrrolido [3,2-b] pyridine-5-carboxylic acids. This path design is ingenious, which can effectively simplify the synthesis step and improve the atomic economy.
When synthesizing 4H-pyrrolido [3,2-b] pyridine-5-carboxylic acid, it is necessary to comprehensively consider the availability of starting materials, the difficulty of reaction conditions, yield and cost, and carefully select the most suitable synthesis method.
What are the physical properties of 4H-thieno [3,2-b] pyrrole-5-carboxylic acid?
4H-imidazolo [3,2-b] pyridine-5-carboxylic acid is an organic compound with important uses in many fields. Its physical properties are as follows:
- ** Appearance and properties **: Under normal conditions, it is mostly white to light yellow crystalline powder. This form is easy to observe and process. In various experiments and industrial operations, it is easy to accurately weigh and transfer, laying a good foundation for subsequent reactions.
- ** Melting point and boiling point **: The melting point is in a specific temperature range, and the exact value will be affected by factors such as purity, usually around [X] ° C. The characteristics of the melting point are of great significance for its identification and purity judgment. If the purity is high, the melting point range is usually narrow and close to the theoretical value; the boiling point is roughly [X] ° C under certain pressure conditions. This parameter is related to its phase transition under different temperature environments, which is of great reference value for the separation and purification process.
- ** Solubility **: The solubility in water is relatively limited, but it shows good solubility in some organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF). This property allows it to choose a suitable solvent to build a reaction system according to the reaction requirements during chemical synthesis to ensure the smooth progress of the reaction. < Br > - ** Stability **: Under normal environmental conditions, it has certain stability. However, it should be noted that it is more sensitive to strong acid and alkali environments, and may undergo chemical reactions to cause structural changes. Extreme conditions such as high temperature, high humidity or light may also affect its stability. Therefore, it should be stored in a cool, dry and dark place to prevent deterioration.
What is the market price of 4H-thieno [3,2-b] pyrrole-5-carboxylic acid?
The "4H-pyrrolido [3,2-b] pyridine-5-carboxylic acid" you mentioned is an important compound in the field of fine chemicals and medicinal chemistry. However, it is difficult to make a conclusion based on the market price, because many factors are interacting.
First, the difficulty of obtaining raw materials and price fluctuations have a deep impact on its cost. If the starting materials required to synthesize this compound are rare and rare, or the price changes significantly due to season, origin, supply and demand, etc., the cost of "4H-pyrrolido [3,2-b] pyridine-5-carboxylic acid" also fluctuates, which in turn affects its market price.
Second, the simplicity of the preparation process is also the key. If it needs to go through multi-step reactions, harsh reaction conditions, such as high temperature, high pressure, special catalysts, etc., or very high requirements for reaction equipment, this will increase production costs and cause its market price to rise.
Third, the market supply and demand situation cannot be ignored. If the demand for this compound increases sharply in fields such as pharmaceutical research and development, but the supply is relatively insufficient, merchants will naturally take advantage of the trend to raise prices; conversely, if demand is low and supply exceeds demand, the price may decline.
Fourth, product purity and quality grade are also closely related to price. High-purity, high-quality grade "4H-pyrrolido [3,2-b] pyridine-5-carboxylic acid" is mostly used in high-end pharmaceutical research and production, and its price is naturally much higher than that of ordinary purity.
To sum up, the market price of "4H-pyrrolido [3,2-b] pyridine-5-carboxylic acid" can range from tens of yuan per gram to hundreds of yuan per gram or even higher. Due to the combined effect of the above factors, the price range fluctuates greatly. To know the exact price, you need to check the current chemical raw material market in detail, consult professional chemical product suppliers, or pay attention to relevant industry trends.