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What are the chemical properties of 4H-Thieno [3,2-b] pyrrole-2-carboxylic acid, ethyl ester
4H-thiopheno [3,2-b] pyrrole-2-carboxylate ethyl ester, this is an organic compound. Looking at its structure, it contains a thiopheno-pyrrole parent nucleus and has a functional group of ethyl carboxylate at the second position.
In terms of its physical properties, it is mostly solid at room temperature and pressure, but the specific properties may vary depending on factors such as purity. Its physical constants such as melting point and boiling point are closely related to the intermolecular force and structure. Due to the existence of a conjugated system in the molecule, its stability is improved, and the melting point and boiling point may be relatively high.
As for chemical properties, in this compound, the ethyl carboxylate functional group can undergo many reactions. Such as hydrolysis reaction, under acidic or basic conditions, ester groups can be hydrolyzed, 4H-thiopheno [3,2-b] pyrrole-2-carboxylic acid and ethanol are formed when acidic; corresponding carboxylate and ethanol are generated when alkaline. Alcoholysis reactions can also occur, exchanging alcohol groups with different alcohols under specific conditions.
In addition, the conjugated system of the thiophene-pyrrole parent nucleus makes it aromatic, and electrophilic substitution reactions can occur, such as halogenation, nitration, sulfonation, etc. The reaction check point may be mainly in the higher density of the parent nuclear electron cloud. Because it contains nitrogen and sulfur heteroatoms, it can also participate in coordination reactions and form complexes with metal ions. Due to its various chemical properties, it has considerable potential application value in the fields of organic synthesis and medicinal chemistry.
What are the common synthesis methods of 4H-Thieno [3,2-b] pyrrole-2-carboxylic acid, ethyl ester
The common synthesis methods of 4H-thiopheno [3,2-b] pyrrole-2-carboxylate ethyl ester have various paths to follow.
One can start from the raw materials containing thiophene and pyrrole structures. Find suitable thiophene derivatives with reactive functional groups at specific positions, and then find pyrrole-related substrates with carboxyl ethyl ester structures. Under suitable reaction conditions, such as in the presence of some metal catalysts, in specific organic solvents, through condensation reactions, thiophene is connected to pyrrole structures, and then the skeleton of the target molecule is constructed. This process requires fine control of the reaction temperature, catalyst dosage, reaction time and many other conditions to obtain a higher yield.
Second, the parent nucleus of thiophene-pyrrole can be constructed first. For example, thiophene is used as the starting material, and the required atoms and groups are introduced into pyrrole through a multi-step reaction to gradually build the thiophene-pyrrole structure. Subsequently, for the obtained product, carboxyl ethyl ester is introduced at the 2-position through an esterification reaction. During the esterification reaction, appropriate alcohols and acids need to be selected, and an appropriate amount of catalyst, such as concentrated sulfuric acid or specific Lewis acid, is added to react at a suitable temperature to promote the efficient esterification reaction.
Third, the target molecule can also be disassembled into several simple fragments by the idea of reverse synthesis analysis. Analyze the structure and properties of each fragment, synthesize each fragment separately, and then splice each fragment with ingenious reactions. For example, the fragment containing thiophene part and the fragment containing pyrrole-2-carboxylate part are first synthesized, and then the two are connected by means of coupling reaction to achieve the synthesis of 4H-thiopheno [3,2-b] pyrrole-2-carboxylate ethyl ester. The key to this path lies in the synthesis design of each fragment and the selection and optimization of the linking reaction.
Where is 4H-Thieno [3,2-b] pyrrole-2-carboxylic acid, ethyl ester used?
4H-thiopheno [3,2-b] pyrrole-2-carboxylate ethyl ester, this compound has applications in many fields such as medicine and materials science.
In the field of medicine, it can be used as a key intermediate to create new drugs. Due to its unique chemical structure, it can interact with specific biological targets. For example, in the development of anti-tumor drugs, compounds with high selective inhibitory activity on tumor cells can be obtained through modification and modification. With precise design, it can target abnormally expressed proteins or signaling pathways in tumor cells, thereby effectively inhibiting tumor growth and spread, bringing new hope for cancer treatment. In the study of drugs for neurological diseases, drugs that can modulate neurotransmitter transmission and repair nerve damage can be developed by optimizing its structure, which is expected to provide new ways for the treatment of Parkinson's disease, Alzheimer's disease and other diseases.
In the field of materials science, 4H-thiopheno [3,2-b] pyrrole-2-carboxylate ethyl ester can be used to prepare functional materials. Its conjugated structure endows the material with special photoelectric properties. In organic optoelectronic materials, it can be used as a light-emitting unit to prepare organic Light Emitting Diode (OLED). OLED has the advantages of self-luminous, wide viewing angle, fast response speed, etc., and is widely used in the field of display screens, such as mobile phones, TV screens, etc., which can improve the display effect, present more vivid colors and higher contrast images. It can also be used to prepare organic solar cell materials. By optimizing its molecular structure, the material can improve the absorption and charge transfer efficiency of sunlight, improve the photoelectric conversion efficiency of solar cells, and help the development of renewable energy.
In the agricultural field, with reasonable design and modification, 4H-thiopheno [3,2-b] pyrrole-2-carboxylate ethyl ester may be developed as a new type of pesticide. With its unique chemical properties, it can act on specific pests or pathogens to achieve efficient, low-toxicity and environmentally friendly pest control. Compared with traditional pesticides, it can reduce environmental pollution and impact on non-target organisms, in line with the sustainable development needs of modern agriculture.
What is the market price of 4H-Thieno [3,2-b] pyrrole-2-carboxylic acid, ethyl ester
What you are asking about is the market price of 4H-thiopheno [3,2-b] pyrrole-2-carboxylate ethyl ester. However, the market price of this compound is difficult to say in a single word. Its price often varies due to many factors.
The first to bear the brunt is its purity. If the purity is extremely high and nearly flawless, it can be used in high-end scientific research or pharmaceutical manufacturing, and its price is high. For example, in the field of fine chemical synthesis, this high purity is required to ensure accurate reaction. Its price per gram may reach hundreds of gold, or even higher.
Furthermore, the scale of production is also critical. If mass production, according to the scale effect of economics, the unit cost decreases and the price also decreases. If it is only customized production in small batches, the cost is high and the price is naturally high.
The balance between supply and demand also affects its price. If the market demand for this product is strong and the supply is limited, in case of a peak in new drug research and development, many drug companies will compete to buy it, and the price will soar. On the contrary, if the supply exceeds the demand, the price will fall.
In addition, the cost of raw materials also affects its price. If the raw materials for synthesizing this compound are scarce or expensive, the production cost will increase greatly, and the price will also rise.
Therefore, in order to know the exact market price of 4H-thiopheno [3,2-b] pyrrole-2-carboxylate, it is necessary to comprehensively consider the above factors and pay attention to the dynamic changes of the market in real time.
What are the physical properties of 4H-Thieno [3,2-b] pyrrole-2-carboxylic acid, ethyl ester
4H-thiopheno [3,2-b] pyrrole-2-carboxylate ethyl ester, is a kind of organic compound. Its physical properties are quite critical and are related to many chemical applications.
First of all, its appearance, under room temperature and pressure, is often white to light yellow solid. This color and morphology are the primary observable characteristics in chemical experiments and industrial production material identification.
times and melting point, the determination of the melting point of this compound is crucial for the determination of purity. After experimental investigation, its melting point is about a specific temperature range. This temperature data can help to identify its purity. If the melting point deviates from the established range, or suggests the presence of impurities.
Furthermore, when it comes to solubility, ethyl 4H-thiopheno [3,2-b] pyrrole-2-carboxylate has a unique solubility in organic solvents. Common organic solvents such as dichloromethane and chloroform have good solubility and can be uniformly dispersed to form a solution. However, in water, its solubility is very small and almost insoluble. This difference in solubility is of great significance in the separation, purification and choice of reaction medium of the compound.
In addition, the density of the compound is also an important physical property. Its density value is specific. In chemical production, it involves material measurement, reaction system ratio and other links. Accurate knowledge of the density can ensure the accuracy and stability of the production process.
In terms of volatility, 4H-thiopheno [3,2-b] pyrrole-2-carboxylate ethyl ester has low volatility, and under normal conditions, it is not easy to evaporate and dissipate. This property is conducive to its storage and transportation, and reduces the loss of volatile components and safety risks.
In summary, the physical properties of 4H-thiopheno [3,2-b] pyrrole-2-carboxylate ethyl ester are related to each other in terms of appearance, melting point, solubility, density and volatility, which together affect its application and treatment in the chemical field.
