4 Bromo 6h Thieno 2 3 B Pyrrole 5 Carboxylic Acid
pyridine pyrrole pyrazine piperidine piperazine

4-bromo-6H-thieno[2,3-b]pyrrole-5-carboxylic acid

    Specifications

    HS Code

    183103

    Name 4-bromo-6H-thieno[2,3-b]pyrrole-5-carboxylic acid
    Molecular Formula C7H4BrNO2S
    Molecular Weight 246.08
    Appearance Solid (predicted)
    Boiling Point 480.7°C at 760 mmHg (predicted)
    Melting Point 254 - 256 °C
    Density 1.937 g/cm³ (predicted)
    Logp 2.02 (predicted)
    Solubility Soluble in DMSO, Methanol
    Pka 1.93±0.10 (Predicted)
    Flash Point 244.5°C (predicted)

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    Frequently Asked Questions

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    What is the chemical structure of 4-bromo-6H-thieno [2,3-b] pyrrole-5-carboxylic acid
    4 - bromo - 6H - thieno [2,3 - b] pyrrole - 5 - carboxylic acid, organic compounds are also. Its molecular structure is unique, containing bromo (bromo), thieno [2,3 - b] pyrrole and carboxylic acid and other groups.
    Looking at its structure, the bromine atom (Br) is connected to a specific position, giving the molecule a certain reactivity. Thiophene pyrrole part, thiophene ring and pyrrole ring fused in a specific way, this fused ring structure affects the physical and chemical properties of the compound. Carboxyl (-COOH) is a strong polar group, which can participate in a variety of chemical reactions, such as ester formation, salt formation, etc.
    In its chemical structure, atoms are connected by covalent bonds to form a specific spatial configuration. Each atom constructs a stable structure according to its own valence state and hybridization mode. In the thiophene-pyrrole ring, the hybrid states of carbon atoms and nitrogen atoms jointly determine the stability of the ring and the distribution of electron clouds. The electronegativity of bromine atoms attracts the surrounding electron clouds, which in turn affects the electron density distribution of the whole molecule. The presence of carboxyl groups makes the molecule acidic, and protons can be released under appropriate conditions to participate in acid-base reactions. In conclusion, the chemical structure of 4-bromo-6H-thieno [2,3-b] pyrrole-5-carboxylic acid is the whole of multiple group interactions, which determines its unique chemical properties and reactivity.
    What are the main uses of 4-bromo-6H-thieno [2,3-b] pyrrole-5-carboxylic acid
    4-Bromo-6H-thiopheno [2,3-b] pyrrole-5-carboxylic acid, which has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate in organic synthesis. In the process of many innovative drug development, its unique chemical structure is often used to build a molecular skeleton with specific biological activities. For example, in the creation of anti-tumor drugs, it may be cleverly modified to precisely bind to specific targets of tumor cells, thereby inhibiting the growth and proliferation of tumor cells, just like a "shackle" tailor-made for tumor cells, restricting their arbitrary reproduction.
    In the field of materials science, this compound also shows potential application value. Due to its special electronic structure and optical properties, it may be applied to the preparation of organic optoelectronic materials. Such as organic Light Emitting Diode (OLED), if it is reasonably introduced, the luminous efficiency and stability of the device can be optimized, as if adding a boost to the OLED device, making it shine more brightly in the display field.
    In the field of pesticide chemistry, 4-bromo-6H-thiopheno [2,3-b] pyrrole-5-carboxylic acid may be used as an active ingredient, and a new type of high-efficiency and low-toxicity pesticide can be developed through appropriate derivatization reaction. With its unique mechanism of action against certain pests or pathogens, it can achieve precision strikes and ensure the healthy growth of crops, just like a loyal guardian of the farmland, protecting crops from harm.
    What are the synthesis methods of 4-bromo-6H-thieno [2,3-b] pyrrole-5-carboxylic acid
    To prepare 4-bromo-6H-thieno [2,3-b] pyrrole-5-carboxylic acid, the following ancient method can be used.
    First, the condensation reaction is carried out with suitable starting materials, such as sulfur-containing and nitrogen-containing heterocyclic precursors, under appropriate reaction conditions. The reaction is often assisted by a specific catalyst to proceed in the desired direction. This catalyst needs to be carefully selected, and its activity and selectivity are crucial to the success or failure of the reaction.
    The condensation product is then brominated. The method of bromination, or using liquid bromine in a specific solvent, operates at a mild temperature and reaction time; or using brominating reagents such as N-bromosuccinimide (NBS), which are milder and can reduce the occurrence of side reactions. During operation, the reaction temperature, solvent polarity and the ratio of the reactants need to be carefully controlled.
    After the brominated product is obtained, the carboxylation reaction is carried out. Carboxylation means, or the method of reacting with metal-organic reagents and carbon dioxide. First, the substrate interacts with metal reagents such as organolithium reagents or Grignard reagents to generate corresponding metal-organic intermediates. This intermediate has high activity and can react efficiently with carbon dioxide to introduce carboxyl groups. < Br >
    After the reaction is completed, it still needs to be separated and purified. Or use column chromatography to separate the product with a suitable eluent according to the difference in polarity between the product and the impurity; or use recrystallization to select a suitable solvent to make the product crystallize and precipitate at a suitable temperature to achieve the purpose of purification.
    The whole synthesis process requires careful adjustment of the reaction conditions at each step and close monitoring of the reaction process, so as to improve the yield and purity of the product, and finally obtain 4-bromo-6H-thieno [2,3-b] pyrrole-5-carboxylic acid.
    What are the physical properties of 4-bromo-6H-thieno [2,3-b] pyrrole-5-carboxylic acid
    4-Bromo-6H-thieno [2,3-b] pyrrole-5-carboxylic acid (4-bromo-6H-thieno [2,3-b] pyrrole-5-carboxylic acid) is one of the organic compounds. Its physical properties are quite important, and it is related to its performance in various chemical processes and applications.
    Looking at its properties, it may be in a solid state at room temperature and pressure. Due to the interaction between molecules such as van der Waals force and hydrogen bonds, it has a relatively orderly arrangement, so it is a solid state.
    The melting point is actually a key physical property. After many experimental investigations, it can be seen that its melting point is synergistically affected by the bromine atom, carboxyl group and thiopheno-pyrrole ring in the molecular structure. The introduction of bromine atom, due to its large atomic weight and certain polarity, can enhance the intermolecular force, thereby increasing the melting point. The carboxyl group can form both hydrogen bonds and polarity, and also contribute to the increase of the melting point. However, the specific melting point value still needs to be accurately determined by experiments. Due to different experimental conditions, such as heating rate and sample purity, the melting point measurement results can be slightly different.
    In terms of solubility, the performance of the compound in organic solvents can also be followed. Due to the fact that the molecule contains both a polar group (carboxyl group) and a non-polar thiophene-pyrrole ring, it may have some solubility in polar organic solvents, such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF). This is because polar solvents and carboxyl groups can attract each other through hydrogen bonding, which prompts the molecules to disperse in the solvent. In non-polar organic solvents, such as n-hexane, the solubility may be poor. Although the non-polar part and the non-polar solvent have van der Waals force, the existence of polar carboxyl groups destroys the compatibility between the whole and the non-polar solvent.
    In addition, the color state of the compound, when pure, may be white to light yellow solid. The formation of this color is related to the electron transition in the molecular structure. The conjugated system, that is, the conjugated structure formed by the thiopheno-pyrrole ring, can absorb light of a specific wavelength and thus exhibit the corresponding color. And because the lone pair electrons of the bromine atom can participate in the conjugation, it also has a certain fine-tuning effect on the color.
    In summary, the physical properties of 4-bromo-6H-thieno [2,3-b] pyrrole-5-carboxylic acid, such as physical state, melting point, solubility and color, are closely related to the molecular structure. In-depth exploration of its physical properties is of great significance in many fields such as organic synthesis and drug development.
    What is the price range of 4-bromo-6H-thieno [2,3-b] pyrrole-5-carboxylic acid in the market?
    Today I have a question, what is the price range of 4-bromo-6H-thieno [2,3-b] pyrrole-5-carboxylic acid in the market. This is an organic compound, and its price often varies depending on quality, purity, supply and market supply and demand.
    Looking at the past market conditions, if it is an ordinary purity, the price per gram may be between tens and hundreds of yuan. However, if the purity is extremely high, reaching the experimental research level, especially suitable for high-end chemical synthesis or drug development, the price is higher, per gram or over 1,000 yuan.
    Also, when purchasing in bulk, the unit price may be reduced due to the scale effect. If the purchase volume is in kilograms, the price may drop to tens of yuan per gram. However, this is all based on past market speculation. Today's market fluctuates frequently. The specific price still needs to be consulted in detail with chemical raw material suppliers, reagent sellers, etc., to determine the current accurate price range.