4 Bromo 1h Pyrrole 2 Carboxylic Acid Ethyl Ester
pyridine pyrrole pyrazine piperidine piperazine

4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester

    Specifications

    HS Code

    668957

    Name 4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester
    Molecular Formula C7H8BrNO2
    Molecular Weight 218.048 g/mol
    Cas Number 14524-95-5
    Appearance Off - white to light yellow solid
    Melting Point 83 - 87 °C
    Boiling Point 274.6 °C at 760 mmHg
    Density 1.537 g/cm³
    Flash Point 119.9 °C
    Solubility Soluble in organic solvents like dichloromethane, chloroform

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    General Information
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    Frequently Asked Questions

    As a leading 4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester
    4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester, an organic compound whose molecule contains bromine atoms, pyrrole rings, and carboxyl ethyl ester groups. It has specific chemical properties and is widely used in the field of organic synthesis.
    In terms of physical properties, it is mostly solid. Due to the intermolecular forces, the melting point and boiling point are determined by the molecular structure and interaction. In view of the polar groups, it may have a certain solubility in common organic solvents such as ethanol and dichloromethane, but its solubility in water may be limited due to its non-strongly polar compounds.
    When it comes to chemical properties, bromine atoms are highly active and can participate in many reactions. For example, in the nucleophilic substitution reaction, the bromine atom is easily replaced by the nucleophilic reagent. Due to the large electronegativity of the bromine atom, the bond connected to the carbon atom is polar, and the carbon is partially positively charged, which is easily attacked by the nucleophilic reagent. For example, when reacting with sodium alcohol, the bromine atom may be replaced by an alkoxy group to form ether derivatives.
    The pyrrole ring also has unique reactivity. The pyrrole ring is an electron-rich aromatic ring, which is prone to electrophilic substitution. Since the lone pair electrons on the nitrogen atom participate in the conjugation, the electron cloud density on the ring increases, and it is easier to attract electrophilic reagents. The common electrophilic substitution check point is the 3rd position of the pyrrole ring If it reacts with a halogenated reagent, a halogen atom can be introduced on the pyrrole ring.
    Carboxyethyl ester groups can undergo hydrolysis. Under acidic or basic conditions, ester groups can be hydrolyzed. Under acidic conditions, hydrolysis is a reversible reaction, resulting in 4-bromo-1H-pyrrole-2-carboxylic acid and ethanol; under basic conditions, hydrolysis is more complete, resulting in carboxylic salts and ethanol, which can be obtained by subsequent acidification treatment. In addition, carboxyethyl ester groups can also participate in transesterification reactions such as transesterification reactions, and react with other alcohols under the action of catalysts to form new ester compounds.
    What are the main uses of 4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester
    4-Bromo-1H-pyrrole-2-carboxylate ethyl ester, this substance has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. It plays an indispensable role in the preparation process of many drugs. For example, in the synthesis of some heterocyclic drugs with specific physiological activities, it can be used as a starting material through a series of delicate reactions to construct complex and unique molecular structures.
    In the field of materials science, it also has its uses. It can participate in the synthesis process of some functional materials. By ingeniously modifying and modifying its structure, it endows the material with unique optical, electrical and other properties, and then is used in cutting-edge fields such as optoelectronic materials.
    In organic synthetic chemistry, it appears more frequently. As an important synthetic building block, chemists can introduce different functional groups through various classical organic reactions, such as nucleophilic substitution, coupling reaction, etc., by virtue of its lively reaction check point, so as to expand the structural diversity of organic molecules and lay the foundation for exploring the properties and functions of new organic compounds. In short, 4-bromo-1H-pyrrole-2-carboxylate ethyl ester plays a pivotal role in many chemistry-related fields, promoting the continuous development and progress of related disciplines.
    What is the synthesis method of 4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester
    The synthesis of 4-bromo-1H-pyrrole-2-carboxylic acid ethyl ester is an important topic in the field of organic synthesis. To synthesize this compound, the following methods are often followed.
    First, pyrrole is used as the starting material. First, pyrrole is protected, and its nitrogen atom is shielded with a suitable protective group to prevent the nitrogen atom from being affected in subsequent reactions. Commonly used protective groups include tert-butoxycarbonyl (Boc). After protection, a carboxyl group is introduced at the 2-position of pyrrole. 2-Carboxyl pyrrole derivatives can be obtained by using strong basic reagents, such as butyl lithium, to lithium pyrrole at the 2-position, and then reacting with carbon dioxide. Subsequently, the carboxyl group is esterified, and ethanol and suitable catalysts, such as concentrated sulfuric acid or p-toluenesulfonic acid, are heated and refluxed to obtain 2-carboxylate ethyl pyrrole derivatives. Finally, the protective group on the nitrogen atom is removed, and the bromine atom is introduced at the 4-position of pyrrole. In the method of introducing bromine atoms, bromination reagents such as liquid bromine or N-bromosuccinimide (NBS) can be used under appropriate solvents and reaction conditions, so that ethyl 4-bromo-1H-pyrrole-2-carboxylate can be obtained.
    Second, other compounds containing pyrrole structures can also be used as starting materials. If the starting material already has some desired structures, such as pyrrole derivatives of 2-ethyl carboxylate, it can be directly brominated at the 4-position. The choice of bromination reaction conditions is crucial, and the activity of the substrate and the selectivity of the reaction need to be considered. Factors such as temperature, solvent and amount of brominating reagent will all affect the reaction result. Usually, under mild conditions, NBS as brominating reagent, in an inert solvent such as dichloromethane, and in the presence of an appropriate catalyst such as benzoyl peroxide, bromine atoms can be introduced at the 4-position to synthesize the target product 4-bromo-1H-pyrrole-2-carboxylate ethyl ester.
    When synthesizing this compound, the conditions of the reaction steps and the purification and separation of the intermediate need to be carefully controlled in order to improve the yield and purity of the product and achieve the expected synthesis goal.
    What is the market price of 4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester
    The market price of ethyl 4-bromo-1H-pyrrole-2-carboxylate often varies due to a variety of factors, and it is difficult to cover it up.
    First discuss the difficulty of its preparation. If the preparation process is complicated, multiple steps are required, and the conditions of each step are strictly controlled, the raw materials are rare, the reagents are expensive, or the reaction yield is low, the preparation cost is high, and the market price is also high. On the contrary, if the preparation process is simple, the raw materials are easy to purchase, and the yield is quite high, the cost will decrease and the price will also decrease.
    Look at the market supply and demand again. If there is a strong demand for it in the fields of medicine, chemical industry, etc., but the supply is limited and the supply is in short supply, the merchant will raise the price to make a big profit; if the demand is low and the supply is excessive, the price will be lowered accordingly in order to seek sales.
    In addition, the number of manufacturers also has an impact. There are many manufacturers and fierce competition. In order to compete for market share, the price is often more reasonable, and there may even be low-price competition. If the manufacturers are rare and almost monopolized, the price will be easily controlled by a few hands and maintained at a high level.
    From the perspective of past market conditions, the price fluctuates greatly. Sometimes it can reach tens of yuan per gram, and sometimes the price may rise or fall due to the above factors. To know its accurate current market price, you can consult chemical raw material suppliers, consult professional chemical product trading platforms, or refer to recent market survey reports to obtain a more accurate number.
    4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester in storage and transportation
    4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester is an organic chemical, and many matters must be paid attention to during storage and transportation.
    Its properties may be unstable and sensitive to light and heat. Therefore, when storing, it should be placed in a cool and dark place, and sealed tightly. If exposed to light and heat, it may decompose and deteriorate, damaging quality and purity.
    And because of its toxicity and irritation, strict safety procedures should be followed when operating. The storage place should be dry and well ventilated, away from fire sources, heat sources and strong oxidants to prevent the risk of fire and explosion.
    During transportation, it is also necessary to ensure that the packaging is intact to prevent its leakage. Suitable transportation tools and packaging materials must be selected in accordance with the regulations for the transportation of hazardous chemicals. And the transportation environment should also be temperature controlled, protected from light, and avoid violent vibration and collision.
    When handling, operators must wear suitable protective equipment, such as gloves, goggles and protective clothing, to prevent contact and inhalation from endangering the body.
    These precautions are to ensure the safe storage and transportation of 4-bromo-1H-pyrrole-2-carboxylate, and to protect people's safety and the environment from pollution.