(4,5-dibromo-1H-pyrrol-2-yl)(phenyl)methanone

(4,5-Dihydro-1H-pyrrole-2-yl) (benzyl) acetonitrile, the main uses of this substance are as follows:
In the field of organic synthesis, it is often used as a key intermediate. Because its molecular structure contains a specific combination of functional groups, acetonitrile, pyrrole ring and benzyl group, endow it with unique reactivity and selectivity. For example, the pyrrole ring part can be electrophilic substitution reaction, introducing various functional groups on the ring to achieve structural modification, and then building a more complex organic compound skeleton, laying the foundation for drug research and development, total synthesis of natural products and other work.
In the field of pharmaceutical chemistry, this compound has potential biological activity. Studies have shown that some fragments in its structure may interact with specific targets in organisms. Based on this, researchers can optimize and modify its structure, design and synthesize a series of derivatives. Through activity screening, it is expected to discover lead compounds with therapeutic efficacy for specific diseases, providing important clues for the development of innovative drugs.
In the field of materials science, using its reactivity, it can participate in the synthesis of polymer materials. By copolymerizing with other monomers, its unique structural units are introduced into the polymer main chain or side chain, thereby endowing the material with special properties, such as improving the solubility, thermal stability, optical properties, etc., and expanding the application of materials in different fields, such as new optical materials, high-performance polymer films, etc.

There are many methods for the synthesis of (4,5-dibromo-1H-pyrrole-2-yl) (phenyl) ethyl ketone, each with its own advantages and disadvantages, which are described in detail below.
First, halogenated aromatics and pyrrole-containing halides are used as raw materials by metal-catalyzed coupling reaction. For example, under palladium catalysis, 4,5-dibromo-1H-pyrrole-2-halide interacts with phenyl magnesium halide Grignard reagent, during which the palladium catalyst promotes the formation of carbon-carbon bonds. After a series of complex electron transfer and intermediate conversion, the target product can be obtained. The advantage of this method is that the reaction selectivity is quite high, and the required carbon-carbon bond can be precisely constructed. However, the reaction conditions are strict, the metal catalyst is expensive, and the preparation of Grignard reagents requires an anhydrous and anaerobic environment, and the operation is complicated.
Second, it is synthesized by the reaction of pyrrole derivatives with acetophenone derivatives. Pyrrole is first brominated to obtain 4,5-dibromo-1H-pyrrole derivatives, and then reacted with acetophenone derivatives under the action of acidic or basic catalysts under specific conditions. Taking alkaline catalysts as an example, alkalis can activate acetophenone α-hydrogen to form carbon anions, attack specific positions on pyrrole derivatives, and then build target molecular structures. This approach is relatively common in raw materials and is slightly simpler to operate, but the reaction process may produce a variety of by-products, and the separation and purification work is heavy.
Third, based on the benzene ring and pyrrole ring, the substituents are gradually introduced. The acetophenone structure is first constructed, and then bromine atoms are introduced to specific positions in the pyrrole ring through electrophilic substitution and other reactions to achieve the synthesis of 4,5-dibromo-1H-pyrrole-2-yl (phenyl) ethanone. This strategy is flexible, and the reaction steps and conditions can be adjusted as needed to prepare analogs with different substituents. However, the reaction steps are lengthy and the overall yield may be limited.

(4,5-Dichloro-1H-pyrazole-2-yl) (phenyl) acetonitrile is an organic compound. Its physical properties are as follows:
Viewed, it is often in the shape of white to off-white crystalline powder, which makes it easy to handle and measure in many chemical reactions and preparations.
Smell, usually without significant odor, this characteristic makes it easy to operate and use, and it will not cause trouble to the environment and users due to strong odor.
When it comes to the melting point, it is about 120-125 ° C. This melting point characteristic is of great significance for its synthesis, purification and identification. In the heat treatment process, the purity of the substance can be judged according to the melting point range. If the melting point is accurate and the melting range is narrow, it often means higher purity; conversely, if the melting point is deviated or the melting range is wide, it suggests that there may be impurities.
Solubility is also a key physical property. It is slightly soluble in water, but soluble in common organic solvents such as dichloromethane, chloroform, ethanol, acetone, etc. This solubility characteristic determines its applicability in different reaction systems. In organic synthesis reactions, selecting a suitable organic solvent to dissolve the substance can promote the reaction to proceed more efficiently, because the organic solvent can provide a suitable environment for the reaction and enhance the contact and interaction between the reactants. In the process of separation and purification, high-purity products can be obtained by means of extraction and recrystallization according to their solubility differences.

(4,5-diyne-1H-pyrrole-2-yl) (phenyl) acetonitrile, this physical property is particularly important, and it is related to many chemical reaction uses.
Its chemical properties, the first word stability. Under normal circumstances, (4,5-diyne-1H-pyrrole-2-yl) (phenyl) acetonitrile can maintain a relatively stable state. In case of high temperature, open flame or strong oxidant, it is prone to violent reactions, even the risk of explosion, so when storing and using, it is necessary to avoid these conditions.
When it comes to solubility, this compound exhibits good solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide. This property makes it possible to use these solvents as a medium to effectively disperse and participate in the reaction in many organic synthesis reactions, which is greatly conducive to the progress of the reaction.
(4,5-diyne-1H-pyrrole-2-yl) (phenyl) acetonitrile contains active functional groups such as alkynyl, pyrrole and nitrile. The alkynyl group can participate in many classical reactions, such as the addition reaction of alkynes, which can be added with electrophilic reagents such as hydrogen halides and halogens to form halogenated alkynes derivatives. Pyrrole groups have electron-rich properties and are prone to electrophilic substitution reactions. They can introduce various substituents on pyrrole rings to expand the structural diversity and functional properties of compounds. Nitrile groups are also active and reactive, and can be hydrolyzed to form carboxylic acids or converted into amine compounds through reduction reactions.
Due to its special chemical properties and structure, (4,5-diyne-1H-pyrrole-2-yl) (phenyl) acetonitrile can be used as a key intermediate in the field of medicinal chemistry to assist in the construction of new drug molecules. In the field of materials science, materials with unique optoelectronic properties can be prepared through rational design and modification.

It is difficult to determine the price range of (4,5-dibromo-1H-pyrrole-2-yl) (phenyl) acetonitrile in the market. This is because the price is often affected by many factors, such as the source of materials, the complexity of the preparation process, the state of market supply and demand, and the difference in quality specifications.
If the material source is wide and easy to prepare, the price may be lower; conversely, if the material is rare, cumbersome and the demand is strong, the price will be higher.
Furthermore, the prices quoted by different merchants may also be different, because the cost accounting and business strategies of each merchant are different. Some merchants focus on small profits but quick turnover, and the price may be close to the people; some merchants focus on high-end quality, but the price is higher.
To clarify its exact price range, you can obtain a relatively accurate price range by carefully checking the market information of chemical raw materials, consulting relevant suppliers, or looking at recent transaction records. However, without detailed information at the moment, it is difficult to directly give the exact number of its price range.