3-(N-Tosyl-L-alaninyloxy)-5-phenylpyrrole

3-%28N-Tosyl-L-alaninyloxy%29-5-phenylpyrrole is an important compound in the field of organic synthetic chemistry. It has a wide range of main uses and has important applications in many fields.
In the field of organic synthesis, this compound is often used as a key intermediate. Because of its unique structure, it can participate in a variety of chemical reactions and help build more complex organic molecular structures. For example, it can react with other organic reagents under specific reaction conditions, such as nucleophilic substitution and electrophilic addition, and then generate organic compounds with special functions or structures. This is of great significance in the field of medicinal chemistry and can be used to create new drug molecules. Drug developers can modify and modify the structure of this compound based on its characteristics, in order to obtain drug lead compounds with better pharmacological activity and lower toxicity, laying the foundation for the development of new drugs.
Furthermore, in the field of materials science, 3-%28N-Tosyl-L-alaninyloxy%29-5-phenylpyrrole also has potential applications. After appropriate chemical modification and processing, it can be introduced into the structure of polymer materials to impart specific properties to the material. It can improve the thermal stability and mechanical properties of the material, or endow the material with special properties such as optical activity, thereby expanding the application range of materials, such as new optical materials, high-performance engineering plastics and other fields.
In addition, in the field of asymmetric synthesis, this compound can be used as a chiral adjuvant to participate in asymmetric reactions because it contains chiral centers. Through its chiral induction, it can selectively synthesize products of specific configurations, improve the stereoselectivity and enantiomer excess value of the reaction, and play a key role in the synthesis of optically active natural products and chiral drugs, promoting the development of asymmetric synthetic chemistry.

The synthesis method of 3- (N-p-toluenesulfonyl-L-alanyloxy) -5-phenylpyrrole has been around for a long time and is described in detail below.
First take an appropriate amount of p-toluenesulfonyl chloride and place it with L-alanine in a suitable reaction vessel. Add an appropriate amount of acid binding agent, such as pyridine, to create an environment conducive to the reaction. This step aims to acylate p-toluenesulfonyl chloride with L-alanine to generate N-p-toluenesulfonyl-L-alanine. The reaction process needs to control the temperature, and it should be maintained at a low temperature, such as between 0 and 5 ° C, to ensure the selectivity and yield of the reaction.
After the first step of the reaction is completed, the product is separated and purified. Recrystallization or column chromatography is often used to obtain pure N-p-toluenesulfonyl-L-alanine.
Then, the product is mixed with 5-phenylpyrrole-3-ol and placed in another reaction vessel. Add an appropriate amount of condensing agent, such as dicyclohexyl carbodiimide (DCC), and an appropriate amount of catalyst, such as 4-dimethylaminopyridine (DMAP). This reaction needs to be carried out in an organic solvent, such as dichloromethane. The reaction temperature can be controlled near room temperature, and the reaction can be stirred for several hours. During this process, the carboxyl group of N-p-toluenesulfonyl-L-alanine and the hydroxyl group of 5-phenylpyrrole-3-alcohol undergo a condensation reaction to generate the target product 3- (N-p-toluenesulfonyl-L-alanyloxy) -5-phenylpyrrole.
After the reaction is completed, the insoluble matter is removed by filtration, and the filtrate is then distilled under reduced pressure to remove the organic solvent. Finally, the product was further purified by recrystallization or column chromatography to obtain pure 3- (N-p-toluenesulfonyl-L-alanyloxy) -5 -phenylpyrrole. Thus, the synthesis of this compound is completed.

3 - (N - p-toluenesulfonyl - L - alanyloxy) - 5 - phenylpyrrole is also an organic compound. Its physical and chemical properties are quite important, and are related to the application and characteristics of this compound.
In terms of its physical properties, the melting point of this substance is a key parameter that defines its phase transition. However, due to the lack of specific data, it is difficult to determine its specific value. However, in general, compounds containing such functional groups have melting points that vary depending on intermolecular forces. Structures such as phenyl groups and sulfonyl groups in the molecule can enhance intermolecular interactions and increase the melting point.
Its solubility is also an important physical property. In organic solvents, such as dichloromethane, chloroform and other halogenated hydrocarbons, the organic part in its structure has similar miscibility with halogenated hydrocarbons, or has good solubility. In water, due to the strong overall hydrophobicity of the molecule, only a small amount is soluble or insoluble.
As for the chemical properties, the pyrrole ring in this compound has certain aromatic properties and can undergo electrophilic substitution reaction. The N-p-toluenesulfonyl-L-alanyloxy group attached to its nitrogen atom changes the electron cloud density distribution of the pyrrole ring, which affects the activity and check point of the electrophilic substitution reaction. For example, the sulfonyl group is an electron-withdrawing group, or the electron cloud density of the pyrrole ring is reduced, the reactivity is slightly lower than that of the pyrrole itself, and the check point is substituted or more inclined to the relatively high electron cloud density.
At the same time, the ester moiety (the ester group structure in N-p-toluenesulfonyl-L-alanyloxy group) can undergo hydrolysis. Under acidic or basic conditions, the hydrolysis mechanism of ester groups is different. When acidic, hydrogen ions first combine with carbonyl oxygen in the ester group to enhance the positive electricity of carbonyl carbons. Water molecules attack carbon positive ions and generate corresponding acids and alcohols through a series of steps. When alkaline, hydroxide ions directly attack carbonyl carbons and eventually generate carboxylic salts and alcohols. This hydrolysis reaction may be of great significance in organic synthesis and metabolism in organisms.

The price of 3 - (N - Tosyl - L - alaninyloxy) -5 - phenylpyrrole is available in Wuwei. This compound may be a rare chemical product, and its price varies for many reasons.
Its preparation is difficult and easy, and it is related to pricing. If the preparation method is complicated, rare raw materials are required, and there are many steps, time-consuming, and special equipment and technology are required, the price must be high. Because of the large increase in cost.
The rarity of the raw materials is also the main reason. If the raw materials required to synthesize this compound are rare or difficult to extract, and the price is high, the price of the finished product will also rise.
The amount of demand also affects the price. If this product is in high demand in scientific research, pharmaceuticals and other fields, the supply is in short supply, and the price may increase; conversely, the demand is small, the supply exceeds the demand, and the price may decrease.
In addition, market competition also plays a role. If multiple manufacturers produce this product, the competition is fierce, and the price may be reduced in order to compete for share; if only a few manufacturers can make it, the price may rise due to monopoly.
Because the exact market conditions are not available, it is difficult to determine the price of 3 - (N - Tosyl - L - alaninyloxy) -5 - phenylpyrrole. For details, you can consult chemical raw material suppliers, chemical trading platforms, or check relevant market reports to get a near-real price.

3 - (N - Tosyl - L - alaninyloxy) - 5 - phenylpyrrole is an organic compound, and its stability needs to be considered from many factors.
First of all, the stability of the structure is discussed. In this compound, aromatic rings such as phenyl and pyrrole have high stability due to the existence of conjugated systems. The conjugated system makes electrons delocalized, the molecular energy drops, and the structure stabilizes. The nitrogen atom is connected to the p-toluenesulfonyl group (N - Tosyl), which has a tensile effect, which can affect the distribution of electron clouds in the surrounding chemical bonds and affect the molecular stability. The L-alanyloxy moiety contains an ester group structure. The carbon-oxygen double bond in the ester group is conjugated with the solitary pair electron of the oxygen atom, which also contributes to the stability.
Second, external factors. When the temperature rises, the thermal motion of the molecule intensifies. If it reaches a certain extent, the vibration of the chemical bond will intensify and cause fracture, and the stability will decrease. This compound is sensitive to humidity. In humid environments, its ester group structure or hydrolysis changes the molecular structure and damages its stability. Furthermore, under light, it may lead to luminescent chemical reactions, which affect its stability.
In polar solvents, the stability is also affected by the interaction between the solvent and the solute, or the change of the charge distribution of the compound. The non-polar solvent interacts weakly with the compound and has little effect on its structure.
Overall, 3 - (N - Tosyl - L - alaninyloxy) - 5 - phenylpyrrole has a certain stability due to its own conjugate structure. However, external temperature, humidity, light and solvents can all affect its stability. Therefore, when storing and using this compound, external conditions need to be carefully controlled to maintain its stability.