3-Methyl-1H-pyrrole-2-carboxylic acid

3-Methyl-1H-pyrrole-2-carboxylic acid, this compound has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the creation of new drugs. Because of its unique chemical structure, it can interact with specific targets in organisms, helping to develop drugs with specific pharmacological activities, such as antibacterial, anti-inflammatory, anti-tumor and other drugs.
In the field of materials science, it can participate in the preparation of functional polymer materials. Through chemical reactions, it is introduced into polymer chains to endow materials with special properties, such as improving material solubility, thermal stability and optical properties. It may have important applications in electronic devices, optical materials and other fields. < Br >
In the field of organic synthesis, as an important building block of organic synthesis, it can construct more complex organic compounds through various chemical reactions, expand the diversity of organic synthesis, and provide key raw materials for organic chemists to explore new reaction paths and synthesis strategies.
Because its structure contains pyrrole rings and carboxyl groups, many chemical reactions can occur, such as esterification and amidation, which provide diverse possibilities for its application in different fields. In the preparation of fine chemical products, such as the synthesis of fragrances and dyes, it may also play an important role in the development of new fragrances and dyes products to meet the needs of different industries.

3 - Methyl - 1H - pyrrole - 2 - carboxylic acid, that is, 3 - methyl - 1H - pyrrole - 2 - carboxylic acid, is an organic compound with specific physical properties, which are described in detail below.
Looking at its properties, it is mostly in a solid state at room temperature. This is due to the existence of various forces between molecules, such as van der Waals forces and hydrogen bonds, which promote the orderly arrangement of molecules, resulting in a solid state.
The melting point is about 160 ° C - 165 ° C. The value of the melting point is closely related to the molecular structure. The atoms in the molecule of the compound are connected by covalent bonds to form a specific spatial structure. The magnitude of the intermolecular force determines the energy required for melting, so this melting point range is presented.
As for solubility, it is slightly soluble in water. Although there are carboxyl groups (-COOH) in the cae molecule that can form hydrogen bonds with water molecules to improve water solubility; however, it also contains methyl (-CH 🥰) and pyrrole rings, which are hydrophobic groups, which will reduce the solubility in water. The two-phase synthesis results in only slight solubility in water. In terms of organic solvents, organic solvents such as ethanol and dichloromethane have relatively good solubility. Organic solvents such as ethanol can form similar intermolecular forces with the molecules of the compound, following the principle of "similar miscibility", so it is more soluble.
Its density is about 1.3 g/cm ³. The density reflects the mass per unit volume of a substance and is determined by the relative molecular weight of the compound molecule and the degree of molecular packing compactness. With a given relative molecular weight, the closer the molecular packing, the higher the density.
The physical properties of 3-methyl-1H-pyrrole-2-carboxylic acids are determined by their molecular structures, and these properties have an important impact on their applications in many fields, such as organic synthesis, drug development, etc.

The chemical synthesis method of 3-methyl-1H-pyrrole-2-carboxylic acid is described in detail today.
First, a suitable pyrrole derivative can be used. First, a pyrrole substrate containing a suitable substituent is taken, and the methyl-based 3-position is introduced through a specific alkylation reaction. This alkylation reaction requires mild reaction conditions and an efficient catalyst to prevent excessive influence on the pyrrole ring. Subsequently, at the second position of the pyrrole ring, the introduction of carboxyl groups is achieved by means of suitable carboxylation reagents, and then the target product 3-methyl-1H-pyrrole-2-carboxylic acid is obtained. For example, a pyrrole derivative is reacted with iodomethane under alkali catalysis to obtain 3-methyl pyrrole derivatives, and then carbon dioxide and suitable metal catalysts are used to achieve carboxylation.
Second, it can also be synthesized by the strategy of constructing pyrrole rings. Compounds containing appropriate functional groups are selected to construct pyrrole rings through cyclization reactions. In the reaction design, the positions of methyl groups and carboxyl groups are cleverly arranged. For example, with specific nitrogen-containing and carbon-containing compounds, under the catalysis of acids or bases, they are cyclized in molecules to generate products containing 3-methyl-1H-pyrrole-2-carboxylic acid structures in one step, and then through appropriate purification steps, a pure target is obtained.
Third, there is a method that uses 3-methylpyrrole as the starting material. First protect 3-methylpyrrole to prevent overreaction of the pyrrole ring in the reaction. Then oxidize the specific position on the pyrrole ring with a suitable oxidant, and then introduce a carboxyl group. After the deprotection step, 3-methyl-1H-pyrrole-2-carboxylic acid can be obtained. Each method has its own advantages and disadvantages, and the optimal synthesis path should be selected according to actual needs and conditions.

I look at this question, and I am inquiring about the price range of 3 - Methyl - 1H - pyrrole - 2 - carboxylic acid in the market. However, the price of this chemical often varies depending on quality, quantity, supplier and market conditions.
If in the context of "Tiangong Kaiwu", although there is no exact price comparison of this chemical, it is common sense that the price of the thin material is high, and the price of the common product is average. In today's world, if this chemical is of ordinary quality, it can be purchased in small quantities for a few to tens of yuan per gram. If it is of good quality and used for special research or production, the price will increase, or more than 100 yuan per gram.
If a large number of purchases are made, such as kilograms, the unit price may be reduced due to economies of scale. However, the market situation changes, the price of raw materials, the difficulty of the process, and the amount of demand all affect the final selling price. Or the price rises suddenly due to the lack of raw materials for a while; or the price drops due to technological progress. Therefore, if you want to know the exact price, you must consult the chemical raw material supplier in detail and compare the quotations of various companies to get a close price range.

3-Methyl-1H-pyrrole-2-carboxylic acid should be stored in a cool, dry and well-ventilated place, away from fire and heat sources. Because of its certain chemical activity, heat or moisture may affect the quality.
This substance should be stored separately from oxidants, strong bases, etc., and must not be mixed. Because it comes into contact with these substances or reacts chemically, it poses a safety hazard. The storage container must be sealed to prevent it from absorbing moisture and deteriorating, and should be placed out of the reach of children.
The storage site needs to prepare suitable materials for containing and handling leaks. If a leak occurs, it can be properly disposed of in time to avoid environmental pollution and safety accidents. Immediately after use, the container should be sealed and returned to the original place to maintain a regular and orderly storage environment. In this way, the 3-methyl-1H-pyrrole-2-carboxylic acid is stable during storage and the quality is safe.