3,5-Dimethyl-1H-Pyrrole-2,4-Dicarboxylic Acid Diethyl Ester

3% 2C5-dimethyl-1H-pyrrole-2% 2C4-dicarboxylic acid diethyl ester, this compound has a variety of chemical properties. Its structure contains a pyrrole ring and two carboxylethyl ester groups, which endows it with unique reactivity.
From the perspective of nucleophilic reactions, pyrrole rings have electron-rich properties. The nitrogen atom on the ring participates in the conjugation of lone pairs of electrons, which increases the density of the ring electron cloud and makes it vulnerable to attack by electrophilic reagents. In case of halogenated hydrocarbons, under the catalysis of suitable bases, nitrogen atoms can nucleophilically replace halogenated hydrocarbons to form N-substituted pyrrole derivatives.
In terms of the properties of carboxylethyl esters, Under the catalysis of acid or base, the ester group can be broken. Hydrolysis under acidic conditions is milder, resulting in corresponding carboxylic acids and ethanol; hydrolysis under basic conditions is more thorough, resulting in carboxylic salts and ethanol, and carboxylic acids can be obtained after acidification.
In addition, the compound has certain optical properties due to its conjugate system. It can undergo electron transition under specific wavelength light irradiation, and has absorption peaks in the ultraviolet-visible spectrum, which can be used for qualitative and quantitative analysis. At the same time, the conjugate structure also affects the stability and reactivity of molecules. The conjugate system reduces the molecular energy and enhances the stability. Some reactions require higher energy initiation.
Because it contains multiple activity checking points, this compound is of great significance in the field of organic synthesis and can be used as a key intermediate to construct complex organic molecules through multi-step reactions. It may have potential applications in pharmaceutical chemistry, materials science and other fields.

3,2,5-Dimethyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester is a crucial compound in the field of organic synthesis, and its main uses are extensive.
First, it plays an extraordinary role in the field of pharmaceutical chemistry. Due to its unique chemical structure, it can be used as a key intermediate for the creation of a variety of drugs. Many biologically active molecules rely on this as a starting material. After exquisite synthesis routes, structures with specific pharmacological activities are constructed. For example, in the development of anti-tumor drugs, by modifying and modifying their structures, they can precisely bind to specific targets of tumor cells to inhibit the proliferation of tumor cells; in the development of nervous system drugs, their interaction with neurotransmitter receptors can be optimized to provide effective drugs for the treatment of nervous system diseases.
Second, it also shines in the field of materials science. Can participate in the preparation of functional materials. After chemical modification, it can give the material special photoelectric properties. Such as the preparation of organic Light Emitting Diode (OLED) materials, this compound participates in the synthesis of materials, which can achieve efficient light emission, improve the performance of OLED display technology, make the display screen clearer and more gorgeous; when preparing nonlinear optical materials, it can enhance the material's response to light, and is used in optical communication, optical information processing and other fields.
Third, in the field of total synthesis of natural products, it is a key synthetic block. Among many complex natural product structures, there are structural fragments related to 3,2,5-dimethyl-1H-pyrrole-2,4-dicarboxylate. Based on it, the multi-step organic synthesis reaction can realize the total synthesis of complex natural products, which is helpful for in-depth study of the biological activity and mechanism of action of natural products, and provides new ideas and material basis for the research and development of new drugs and agricultural chemicals.
Fourth, it is an important substrate in the study of organic synthesis methodologies. Chemists can use it to participate in various organic reactions and explore new reaction paths and methods. Study its reaction conditions and products with different reagents and catalysts, expand the boundaries of organic synthesis chemistry, develop efficient and green organic synthesis methods, and promote the continuous development of organic synthesis chemistry.

To prepare 3- (2,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester, the method is as follows:
First, 2,5-dimethyl pyrrole is used as the starting material. Shilling 2,5-dimethyl pyrrole and an appropriate amount of diethyl succinate are catalyzed by a strong base such as sodium ethanol, and refluxed in a suitable organic solvent such as anhydrous ethanol. The strong base can capture the α-hydrogen of diethyl succinate to generate carbon negative ions, which carry out nucleophilic attack on the α-position of 2,5-dimethyl pyrrole, and then obtain the target product through a series of reactions such as molecular inner ring. After the reaction is completed, the unreacted raw materials and by-products are removed by conventional separation and purification methods, such as vacuum distillation, column chromatography, etc., to obtain pure 3- (2,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester.
The second can be started from 2,5-dimethyl-1H-pyrrole-2-carboxylic acid. First, 2,5-dimethyl-1H-pyrrole-2-carboxylic acid and ethanol are esterified under the catalysis of concentrated sulfuric acid to obtain 2,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester. Then, with a suitable oxidant, such as potassium permanganate, under suitable reaction conditions, the 4-position of the above product is oxidized to introduce a carboxyl group. Then the carboxyl-containing product and ethanol are esterified again under the catalysis of concentrated sulfuric acid, and after careful separation and purification, 3 - (2,5-dimethyl-1H-pyrrole-2,4-dicarboxylic acid diethyl ester can also be obtained.
Third, the furfural derivative is used as the starting material. If 2,5-dimethoxymethyl furfural is used as the raw material, the aldehyde group of furfural is first reduced to the alcohol hydroxyl group through reduction reaction. Subsequently, through halogenation reaction, the alcohol hydroxyl group is converted into a halogen atom with a halogenating agent such as phosphorus tribromide. Then the halogenated product is reacted with diethyl malonate under basic conditions. After hydrolysis and decarboxylation, a pyrrole ring is constructed and a carboxylic acid ethyl ester group is introduced, and the final product is obtained. During separation and purification, suitable methods such as crystallization and extraction are selected depending on the specific reaction system and impurity properties.

Wen Jun's inquiry is about the market price of diethyl 3-dimethyl-1H-indole-2,4-dicarboxylate. The market price of this compound often varies for many reasons.
First, the quality and quantity of the material are the key to the price. If the raw materials are pure and sufficient, and the production is smooth, the price may be slightly flat; if the raw materials are rare, difficult to collect, and difficult to make, the price will be high.
Second, the method of production also affects the price. Simple and convenient method, the cost is reduced and the price is low; if the production requires fine craftsmanship, multiple steps, time-consuming and high cost, the price will also rise.
Third, the supply and demand of the market is also the main reason. If there are many people who need this compound, the demand exceeds the supply, and the price will rise; if the market is saturated, the supply exceeds the demand, and the price will decline.
Fourth, the reputation and credibility of the producer are also relevant. Those with a good reputation have reliable products, and the price may be slightly higher; those with no name, the price may vary.
Generally speaking, the price of this compound varies from hundreds to thousands per gram in the market, and it is difficult to determine its exact value. To know the exact price, you need to consult the business and manufacturer specializing in this chemical, and carefully observe the market situation before you can get its near-real price.

3% 2C5-dimethyl-1H-pyrrole-2% 2C4-dicarboxylate diethyl ester is an important organic compound. When storing and transporting, the following matters must be paid attention to:
First, when storing, be sure to choose a dry, cool and well-ventilated place. Because of its certain chemical activity, humid environments are prone to reactions such as hydrolysis, which in turn damages its quality. As "Tiangong Kaiwu" said "dry and wet are suitable, and things last for a long time", this compound also needs to be properly stored in a suitable humidity environment. And the temperature should also be strictly controlled. If the temperature is too high, it may cause adverse reactions such as decomposition and polymerization, causing deterioration.
Second, because of its certain toxicity and irritation, it needs to be strictly separated from food, drugs, etc. during storage, and significant warning signs are set up to prevent accidental touch and misuse. Just as "Tiangong Kaiwu" emphasizes that dangerous objects should be clearly distinguished and cannot be confused.
Third, during transportation, it is necessary to ensure that the packaging is tight. Packaging materials should have good sealing and corrosion resistance to prevent leakage. "Tiangong Kaiwu" mentions that the transported objects should be stable and comprehensive. If the packaging of this compound is not firm, once it leaks, it will not only pollute the environment, but also pose a threat to the safety of transporters.
Fourth, when transporting, it is necessary to choose the appropriate transportation method and tools in accordance with relevant regulations. Avoid the same transportation as strong oxidizing agents, strong acids and alkalis, because it is prone to violent reactions. This is just like what Tiangong Kaiwu said, things with different physical properties should not be mixed at will, otherwise the consequences will be unimaginable.
In short, the storage and transportation of 3% 2C5-dimethyl-1H-pyrrole-2% 2C4-diethyl dicarboxylate must follow scientific standards and pay attention to details to ensure its quality and safety.