(2S)-1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid;N-cyclohexylcyclohexanamine

The structure of (2S) -1 -tert-butoxycarbonyl-2,3 -dihydropyrrole-2 -carboxylic acid contains a pyrrole ring with a carboxyl group at the 2nd position and a tert-butoxycarbonyl group at the 1st position. In this structure, the pyrrole ring is a five-membered nitrogen-containing heterocycle, tert-butoxycarbonyl at the ortho position of the nitrogen atom (1 position), which is connected by the tert-butyl group to the carbonyl group and the oxygen atom to provide the effect of protecting the amino group; the carboxyl group at the 2nd position is acidic and can participate in a variety of chemical reactions.
The structure of N -cyclohexyl cyclohexylamine is a dicyclohexyl group connected by the nitrogen atom. Cyclohexyl is a six-membered carbon ring with a chair or boat conformation, which has a certain rigidity and spatial structure. The two cyclohexyl groups are connected to the nitrogen atom, which makes the compound basic, and the lone pair of electrons on the nitrogen atom can accept protons.
The two are different in structure and function. (2S) -1 -tert-butoxycarbonyl-2,3 -dihydropyrrole-2 -carboxylic acid is often used in organic synthesis and is used as a key intermediate for the construction of complex compounds. Due to the reactivity of carboxyl groups and protected amino groups, various condensation and substitution reactions can be carried out. N-cyclohexylcyclohexylamine can be used as a catalyst for some organic reactions or as a base reagent in specific systems due to its alkalinity.

(2S) -1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid, this substance is a white to off-white solid, with a melting point in a certain range (about XX ° C, specific needs to be accurately determined experimentally), slightly soluble in water, and has a certain chemical activity due to the carboxyl group and tert-butoxycarbonyl. Carboxyl groups can undergo esterification and salt-forming reactions, and tert-butoxycarbonyl can be deprotected under specific conditions. It is often used in organic synthesis to construct complex compounds containing pyrrole structures.
N-cyclohexyl cyclohexylamine, a colorless to light yellow liquid, with an ammonia odor, boiling point in a specific range (about XX ° C, determined by experiments), and a density of about X g/cm ³. Because the molecule contains two cyclohexyl groups and amino groups, it has certain alkalinity and can react with acids to form salts. It is used as a base reagent in organic synthesis or as a raw material for constructing nitrogen-containing heterocycles, and is also used in rubber additives and other fields. The physical and chemical properties of the two are quite different. (2S) -1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid is solid and has carboxylic acid properties, and N-cyclohexyl cyclohexylamine is liquid and has the properties of basic amines. It plays a unique role in different organic synthesis scenarios.

(2S) -1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid and N-cyclohexyl cyclohexylamine, both of which have applications in many fields.
In the field of pharmaceutical research and development, (2S) -1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid can be used as a key synthetic block, which is helpful for the construction of compounds with specific biological activities due to its special chiral structure. In the design of many drug molecules, such chiral carboxylic acids need to participate in the reaction to precisely regulate the interaction between drugs and targets, improve drug efficacy and reduce side effects. N-cyclohexylcyclohexylamine can be used as an organic base to participate in acid-base reactions in drug synthesis, assist in the conversion of intermediates, or as a structural modifier to optimize the physicochemical properties of drugs, such as solubility and stability.
In the field of materials science, (2S) -1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid can participate in the preparation of functional polymer materials due to its unique structure. By polymerizing with suitable monomers, materials are endowed with special properties such as chiral recognition and adsorption, which are used in the development of chiral separation membranes, sensors and other materials. N-cyclohexylcyclohexylamine can be used as an additive to improve the mechanical properties and thermal stability of materials. For example, it is added to some polymer materials to enhance the toughness and heat resistance of materials and broaden their application range.
In the field of organic synthetic chemistry, both are important organic reagents. (2S) -1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid can participate in many classic organic reactions, such as amidation, esterification, etc., to construct complex organic molecular structures. N-cyclohexyl cyclohexylamine can be used as a nucleophilic reagent or a base catalyst to promote the progress of various organic reactions, providing an effective way to synthesize new organic compounds and assisting organic chemists in exploring novel molecular structures and reaction pathways.

To prepare (2S) -1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid and N-cyclohexyl cyclohexylamine, the method is as follows:
Preparation of (2S) -1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid. Usually start with suitable starting materials, such as pyrrole derivatives with specific configurations. After the step of protecting the amino group, the tert-butoxycarbonyl (Boc) reagent is selected. Under suitable reaction conditions, such as in the environment where an organic base exists, in a suitable solvent, the amino group is fully reacted with the Boc reagent to protect the amino group. Subsequently, for a specific position on the pyrrole ring, the carboxylation reaction is carried out through fine chemical transformation, such as under specific catalyst and reaction conditions, to introduce the carboxyl group. After the reaction is completed, the pure (2S) -1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid can be obtained by means of separation and purification, such as column chromatography.
Re-discussion on the preparation of N-cyclohexylcyclohexylamine. Cyclohexylamine is used as the starting material and reacts with cyclohexylation reagents under suitable reaction conditions. This reaction may require suitable catalysts, such as metal catalysts, to be carried out in an appropriate temperature and pressure environment. During the reaction process, precise control of the reaction conditions is required to ensure the smooth integration of cyclohexyl into cyclohexylamine molecules. After the reaction is completed, the impurities are removed by distillation, extraction and other separation operations, and finally high-purity N-cyclohexylcyclohexylamine is obtained. < Br >
Preparation of these two requires precise control of the conditions of each reaction step. The purity of the raw material, reaction temperature, time, and catalyst dosage are all related to the purity and yield of the product. The operation must be rigorous and meticulous in order to achieve the goal.

The chemical reaction between (2S) -1-tert-butoxicarbonyl-2,3-dihydropyrrole-2-carboxylic acid and N-cyclohexyl cyclohexylamine is like a delicate "natural opening" play.
(2S) -1-tert-butoxicarbonyl-2,3-dihydropyrrole-2-carboxylic acid has a unique structure and contains functional groups such as tert-butoxicarbonyl and carboxyl. N-cyclohexyl cyclohexylamine is connected by two cyclohexyl groups and an amine group.
Both can occur condensation reaction. Under suitable conditions, the carboxyl group of (2S) -1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid and the amine group of N-cyclohexyl cyclohexylamine are like fitting mortise and tenon, removing a molecule of water, forming an amide bond, and generating the corresponding amide compound. This reaction may require the assistance of catalysts, such as condensing agent dicyclohexyl carbodiimide (DCC), to promote the smooth progress of the reaction.
In addition, the tert-butoxycarbonyl of (2S) -1-tert-butoxycarbonyl-2,3-dihydropyrrole-2-carboxylic acid can be removed under specific conditions, resulting in amino-containing compounds, or can further react with N-cyclohexyl cyclohexylamine, such as nucleophilic substitution, and derive a variety of products, which add luster to the field of organic synthesis, such as the construction of more complex nitrogen-containing heterocyclic structures, etc., enriching the variety of organic compounds, just like a craftsman crafting exquisite objects.