2-tert-Butyl 4-ethyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate

2-tert-butyl-4-ethyl-3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Due to its unique structure, it has a pyrrole ring and a specific substituent, and can be derived from many complex organic compounds through various chemical reactions.
In the field of medicinal chemistry, this substance is used as a starting material, and after modification and optimization, it may be able to create novel drugs with biological activity. Pyrrole structures are common in many natural products and drug molecules, and can interact with targets in organisms to exhibit pharmacological activity.
It also has potential uses in materials science. Or it can participate in the preparation of organic materials with special properties, such as optoelectronic materials. Because its structure contains a conjugated system, or endows the material with unique optical and electrical properties.
In summary, 2-tert-butyl-4-ethyl-3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate has important value and application prospects in the fields of organic synthesis, drug development and material preparation, and is valued by chemical research and industrial production.

To prepare 2-tert-butyl-4-ethyl-3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate, there are several common synthesis methods.
First, pyrrole containing the corresponding substituent is used as the starting material. First, take an appropriate pyrrole derivative with some target substituents on the pyrrole ring. After a specific esterification reaction, choose a suitable esterification reagent, such as co-heating with the corresponding alcohol and dehydrating agent under acid catalysis. Using sulfuric acid or p-toluenesulfonic acid as a catalyst, the pyrrole derivative is reacted with alcohol such as ethanol and tert-butyl alcohol in the state of heating and refluxing, and ethyl and tert-butyl ester groups are introduced. This process requires attention to the control of reaction temperature and time. If the temperature is too high or the structure of the pyrrole ring is damaged, and if the time is insufficient, the esterification will be incomplete.
Second, start with the construction of the pyrrole ring. Using compounds containing functional groups such as carbonyl and amino groups as raw materials, pyrrole rings are constructed by condensation reaction and substituents are introduced synchronously. For example, ethyl acetoacetate derivatives, acetone derivatives and ammonia or amine compounds are synthesized by Paal-Knorr under suitable catalyst and reaction conditions. The carbonyl compound is condensed first, and then cyclized to form a pyrrole ring. In this process, by selecting the starting carbonyl compound containing specific substituents, ethyl, tert-butyl, methyl and other substituents can be precisely introduced into the appropriate position of the pyrrole ring, and then the esterification reaction can be carried out to obtain the target product. The key to this path lies in the optimization of condensation and cyclization reaction conditions. The acid-base strength and reaction solvent have a great influence on the reaction process and product yield.
Third, the coupling reaction is catalyzed by metal. First, pyrrole intermediates containing partial substituents and couplable functional groups, such as halogenated pyrrole derivatives, are prepared. Then, with the help of metal catalysts, such as palladium-catalyzed coupling reactions, react with organometallic reagents or halogenated hydrocarbons containing substituents such as ethyl and tert-butyl. This method can efficiently introduce specific substituents, but the cost of metal catalysts is high, and the reaction requires strict reaction environments such as anhydrous and anaerobic, requiring fine manipulation of reaction conditions to improve reaction efficiency and selectivity.

2-tert-butyl-4-ethyl-3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate is one of the organic compounds. Looking at its physical properties, the first word is its phase state. Under normal temperature and pressure, this compound is mostly in the form of a solid state, with a relatively stable state and exists in the form of a powder or crystal.
When it comes to color, it is often white or almost white, pure and uniform in color, and clean and clear in appearance. Its melting point is also one of the important physical properties, but the exact melting point value needs to be determined according to fine experiments, because different preparation processes may vary. However, the approximate range can also be followed, and it usually melts within a certain temperature range. This temperature range can provide preliminary evidence for chemical researchers to judge.
Furthermore, the solubility of this substance is also worth exploring. In organic solvents, such as common ethanol and acetone, it has a certain solubility. In ethanol, with the increase of temperature, the solubility may increase. Due to the increase of temperature, the thermal movement of molecules intensifies, and the interaction between compounds and solvent molecules is enhanced. In water, its solubility is very small. Due to the lack of hydrophilic groups in its molecular structure, hydrophobic hydrocarbons and other parts dominate, making it insoluble in water.
Its density is also one of the keys to physical properties. Although the exact density needs to be accurately measured, according to the characteristics of similar compounds, its density may be similar to that of common organic compounds, and it is within a certain numerical range. In the operation of material measurement and phase separation in chemical experiments, the consideration of density is quite important.
The boiling point of this compound is also the main point of physical properties. The boiling point is the temperature at which a substance changes from a liquid state to a gas state. The boiling point is closely related to the intermolecular force. Due to the presence of groups such as tert-butyl, ethyl, and methyl in the molecule, the intermolecular force presents certain characteristics, resulting in a boiling point in a specific range. However, the exact value also needs to be tested carefully. In conclusion, the physical properties of 2-tert-butyl-4-ethyl-3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate are of great significance in many fields such as chemical synthesis, separation and purification, analysis and identification, etc. Chemists should explore them in detail.

2-tert-butyl-4-ethyl-3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate. This is an organic compound. Its chemical properties are unique and quite interesting.
Let's talk about its physical properties first. It may be a solid at room temperature, with a specific melting point and boiling point. The melting point is the temperature at which a substance changes from a solid state to a liquid state, and the boiling point is the temperature at which a substance changes from a liquid state to a gaseous state. The melting and boiling point of this compound is determined by intermolecular forces. If the intermolecular forces are strong, the melting and boiling point is high; otherwise, it is low. There are alkyl groups such as tert-butyl, ethyl and methyl in the molecule. These alkyl groups are non-polar groups, which will affect the intermolecular forces.
Another is the chemical properties. The pyrrole ring in this compound is an electron-rich system, which is prone to electrophilic substitution. Because the nitrogen atom on the pyrrole ring has a lone pair of electrons, it can participate in the conjugation, which increases the electron cloud density on the ring. For example, under appropriate conditions, it may react with electrophilic reagents such as halogenated hydrocarbons and acyl halides to form substitution products. And the compound contains two ester groups, and the chemical properties of the ester group are also active. Hydrolysis can occur under acidic or basic conditions. When acidic hydrolysis, corresponding carboxylic acids and alcohols are formed; when basic hydrolysis, carboxylic acids and alcohols are formed. The rate and degree of this hydrolysis reaction are affected by reaction conditions such as temperature, pH, etc. At the same time, due to the existence of different substituents in the molecule, there will be electronic effects and spatial effects on the reactivity. The electron cloud distribution of pyrrole ring and ester group may be changed by the electron induction effect of alkyl group, which in turn affects the reactivity.
In addition, the compound may have certain stability, but under extreme conditions such as high temperature and strong oxidants, structural changes may occur. In case of strong oxidant, pyrrole ring may be oxidized to open the ring, which changes the structure and properties of the compound. And the steric resistance of different substituents also affects its chemical properties. Where the steric resistance is large, the reagent is difficult to approach, which will reduce the reactivity. In conclusion, the chemical properties of 2-tert-butyl-4-ethyl-3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate are rich and determined by the interaction of various parts in the molecular structure.

"2 - tert - Butyl + 4 - ethyl + 3,5 - dimethyl - 1H - pyrrole - 2,4 - dicarboxylate" is a difficult question to answer when it comes to the price on the market. The price of this compound depends on many factors.
First, it is related to the difficulty of preparation. If the synthesis method is complicated, rare raw materials are required, after many difficult steps, and the yield is not high, the price will be high. On the contrary, if the preparation process is relatively simple, the raw materials are easy to purchase and inexpensive, the price may be close to the people.
Second, the market demand is also the key. If there is a strong demand for this product in the fields of medicine, materials, etc., and the supply is in short supply, the merchant may raise the price because of it. However, if there is a lack of demand and overproduction, the price may decline.
Third, the impact of purity should not be underestimated. For high purity, the cost of preparation is higher, and the natural price is also higher; for low purity, although the cost is slightly lower, the application is limited, and the price may be lower.
The method of "Tiangong Kaiwu", although there are many traditional processes, may be difficult to fit the price of these modern organic compounds. However, the idea of "expensive grains and cheap gold jade" also makes us know that the value of the product is not only in itself, but also related to the wide and narrow use.
If you want to know the exact price of this product, you can get a relatively accurate price by checking the chemical raw material trading platform, consulting chemical product suppliers, or referring to professional chemical market survey reports.