2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

2 - OXO - 2,5 - DIHYDRO - PYRROLE - 1 - CARBOXYLIC ACID TERT - BUTYL ESTER, Chinese name or 2 - oxo - 2,5 - dihydro - pyrrole - 1 - tert-butyl carboxylate. This compound has a wide range of uses and is often used as a key intermediate in the field of organic synthesis.
The art of organic synthesis, to create complex and unique organic molecules, this compound often plays a role. Because its structure contains specific functional groups, it can interact with other reagents through various chemical reactions, such as nucleophilic substitution and addition, to build a variety of molecular structures. For example, when constructing biologically active heterocyclic compounds, they can participate in cyclization reactions and achieve specific cyclic structures, which is of great significance in the creation of new drug molecules.
Furthermore, in the field of pharmaceutical chemistry, there are also many applications. In the process of many drug development, this compound is used as a starting material or key building block, and it can be modified and derived to obtain compounds with potential biological activities. After pharmacological testing, or effective therapeutic drugs for specific diseases can be found, such as anti-tumor, anti-viral and other drugs, which may be involved in their application.
It can also be seen in the field of materials science. By introducing it into the structure of polymer materials through specific reactions, it may endow the materials with unique properties, such as improving the solubility and thermal stability of the materials, providing an effective way for the development of new functional materials.

2 - OXO - 2,5 - DIHYDRO - PYRROLE - 1 - CARBOXYLIC ACID TERT - BUTYL ESTER is an organic compound with the Chinese name 2-oxo-2,5-dihydropyrrole-1-tert-butyl formate. Its chemical properties are unique and interesting.
This compound contains tert-butoxycarbonyl and 2-oxo-2,5-dihydropyrrole structures. Tert-butoxycarbonyl is relatively stable and has a protective effect on the pyrrole ring. It is often used as an amino protecting group in organic synthesis to avoid the unprovoked reaction of the amino group in the reaction. It is removed at the right time to make the reaction progress in the expected direction.
In the structure of 2-oxo-2,5-dihydropyrrole, the double bond is conjugated with the carbonyl group to give the compound a certain reactivity. Carbonyl is electrophilic and can react with nucleophiles such as alcohols and amines. When exposed to alcohol, or a condensation reaction occurs, the corresponding ester derivatives are formed; when reacted with amines, amide products may be formed.
Double bond sites can participate in addition reactions, such as addition to hydrogen halide, generating different halogenated products according to different reaction conditions and reagents. Under specific catalytic conditions, cyclization can also occur to construct more complex cyclic structures, providing a path for the synthesis of special structural organic compounds.
Under basic conditions, due to the acidic nature of carbonyl α-hydrogen, deprotonation may occur, generating carbon negative ion intermediates, and then reacting with other electrophilic reagents to achieve carbon chain growth or structural modification.
Due to these chemical properties, tert-butyl 2-oxo-2,5-dihydropyrrole-1-formate is widely used in the fields of medicinal chemistry and total synthesis of natural products, assisting in the synthesis of a variety of biologically active or special structural organic compounds.

To prepare tert-butyl 2-OX O-2,5-dihydro-pyrrole-1-carboxylate, there are many methods. One common one is to start with pyrrole, first protect its nitrogen, use tert-butoxycarbonyl (Boc) reagent, such as di-tert-butyl dicarbonate (Boc 2O O), and store it in a base, such as triethylamine, in a suitable solvent, such as dichloromethane, stirred at room temperature, to obtain nitrogen protected by Boc pyrrole. < Br >
times, oxidize it to a suitable oxidizing agent, such as Dess-Martin (Dess-Martin) oxidizing agent, in an organic solvent, such as dichloromethane, at low temperature, oxidize the pyrrole ring to a carbonyl group, and obtain the target product 2-OX O-2,5-dihydro-pyrrole-1-tert-butyl carboxylate.
There is also another method, starting with furan containing a suitable substituent, through a multi-step reaction, first changing its ring to a pyrrole structure, then introducing tert-butoxy carbonyl, and oxidizing the two-site to a carbonyl group, which can also be prepared. For example, starting with 2-methoxyfuran, first react with nitrogen-containing nucleophiles to open the ring, then close the ring to form pyrrole, and then protect nitrogen and oxidize according to the previous method, which can achieve the purpose. All methods have advantages and disadvantages, and need to be based on actual conditions, such as easy access to raw materials, easy control of reaction conditions, high or low yield, etc., choose the appropriate method.

2 - OXO - 2,5 - DIHYDRO - PYRROLE - 1 - CARBOXYLIC ACID TERT - BUTYL ESTER, that is, 2 - OXO - 2,5 - dihydropyrrole - 1 - tert-butyl carboxylate, there are a number of urgent things to pay attention to when storing and transporting this substance.
Let's talk about storage first. Due to its nature, it should be placed in a cool, dry and well-ventilated place. If the storage environment is warm and humid, it may cause the substance to deteriorate. This is because warm heat can accelerate the rate of chemical reactions, and humid environments may cause adverse reactions such as hydrolysis. Furthermore, be sure to keep away from fire and heat sources to prevent disasters such as burning. Because of its flammability, it is easy to be dangerous in case of open flames and hot topics. And it needs to be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Due to its active chemical properties, contact with the above-mentioned substances, or react violently, damage the purity of the material, and even cause safety accidents.
As for transportation, there are also many precautions. The transportation vehicle must be clean and free of other chemicals to avoid contamination. When loading, it should be handled lightly, and it must not be loaded and unloaded brutally to prevent damage to the packaging. If the packaging is damaged and the material leaks, it will not only cause losses, but also pose a threat to the environment and personal safety. During transportation, pay close attention to weather changes to avoid severe weather such as high temperature and heavy rain. High temperature may change the material properties, and heavy rain may cause damage to the packaging in contact with water. And during transportation, a special person needs to supervise and check the status of the goods at any time to ensure safe transportation. In this way, the stability of tert-butyl 2-oxo-2,5-dihydropyrrole-1-carboxylate during storage and transportation can be guaranteed.

2 - OXO - 2,5 - DIHYDRO - PYRROLE - 1 - CARBOXYLIC ACID TERT - BUTYL ESTER is 2 - oxo - 2,5 - dihydropyrrole - 1 - tert-butyl carboxylate. The relevant safety information of this compound is as follows:
This compound may be dangerous. From the perspective of chemical structure, it contains specific functional groups, such as pyrrole ring and tert-butyl ester group. Pyrrole ring compounds are partially biologically active or have effects on organisms. Under specific conditions, tert-butyl ester groups may undergo reactions such as ester hydrolysis.
During operation, attention should be paid to protection. Because it may be irritating to the skin, after contact or cause skin redness, itching and other discomfort, it is advisable to wear protective gloves for operation. If you accidentally contact, you should quickly rinse with plenty of water and seek medical attention as appropriate. It is also irritating to the eyes and can cause eye pain, tears, etc. Wear goggles during operation. Once it enters the eyes, rinse with plenty of water immediately and seek medical help.
For storage, it should be stored in a cool, dry and well-ventilated place, away from fire sources and oxidants. Because it has certain chemical activity, it is exposed to heat, open flame or oxidant, or may cause chemical reactions, and even risk combustion and explosion. When storing, it should be separated from other chemicals to prevent interaction.
In the transportation process, it is also necessary to follow relevant regulations. Due to its special nature, it is necessary to ensure that the packaging is intact during transportation, avoid collision and heat, and ensure transportation safety.
In short, the operation, storage and transportation of 2-oxo-2,5-dihydropyrrole-1-tert-butyl carboxylate must be strictly carried out in accordance with safety regulations to prevent accidents and ensure personnel safety and environmental safety.