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What is the chemical structure of 2-bromo-4H-furo [3,2-b] pyrrole-5-carboxylic acid
This is an investigation into the chemical structure of 2-bromo-4H-furano [3,2-b] pyrrole-5-carboxylic acid. Looking at its name, "2-bromo" shows that the bromine atom is attached to the specific position of the furano-pyrrole ring, that is, position 2. "4H-furano [3,2-b] pyrrole" shows that it is formed by fusing the furan ring with the pyrrole ring, and according to the nomenclature, the fusing method of the two is established, and the hydrogen atom is at position 4. The epicarboxyl group of "5-carboxylic acid" is attached to the fused ring system at position 5.
In this structure, the furan ring is aromatic, which consists of four carbon atoms and one oxygen atom to form a five-membered ring, and the electron cloud is evenly distributed. The pyrrole ring is also aromatic, which consists of four carbon atoms and one nitrogen atom to form a five-membered ring. The lone pair of nitrogen atoms participates in the conjugation of electrons to enhance the stability of the ring. The two fuse to form a unique conjugated system, which affects the distribution and chemical activity of molecular electron clouds. The bromine atom is a halogen atom, which has an electron-absorbing induction effect, which reduces the density of ortho and para-electron clouds, and affects the activity and positional selectivity of electrophilic substitution reactions on the Carboxyl groups are strong polar groups, acidic, can participate in acid-base reactions, esterification reactions, etc., and have a great influence on molecular physical and chemical properties, such as solubility, boiling point, etc.
In summary, the chemical structure of 2-bromo-4H-furano [3,2-b] pyrrole-5-carboxylic acid is unique, and the interaction of each group endows it with specific chemical properties and reactivity.
What are the common synthesis methods of 2-bromo-4H-furo [3,2-b] pyrrole-5-carboxylic acid
2-Bromo-4H-furo [3,2-b] pyrrole-5-carboxylic acid is an organic compound, and its synthesis method is quite critical. Common synthesis paths include compounds containing furan and pyrrole structures as starting materials.
The starting material can be halogenated to introduce bromine atoms at specific locations. This halogenation step requires careful selection of halogenating reagents, such as N-bromosuccinimide (NBS), and fine regulation of reaction conditions, such as reaction temperature and solvent. Excessive temperature may cause excessive halogenation; solvent discomfort may affect reaction rate and selectivity. < Br >
After the bromine atom is introduced, the carboxyl group can be constructed at the target position by a suitable carboxylation reaction. In this process, a metal reagent, such as an organolithium reagent or a Grignard reagent, may be used, and then reacted with carbon dioxide to achieve carboxylation. This step requires strict reaction environment, and requires anhydrous and oxygen-free to avoid the inactivation of metal reagents.
There is also a strategy of constructing furan and pyrrole rings by multi-step reaction. First, the furan-containing fragment and the pyrrole fragment are synthesized separately, connected through a condensation reaction, and then the bromine atom and the carboxyl group are introduced in turn. Although this path has many steps, it requires extremely high selectivity and yield control for each step of the reaction Each step of the reaction needs to be precisely controlled, from the proportion of raw materials, reaction time to post-processing operation, all affect the purity and yield of the final product.
When synthesizing 2-bromo-4H-furo [3,2-b] pyrrole-5-carboxylic acid, the reaction steps are closely connected, and the reaction conditions and operation skills are very high. Chemists need to orchestrate and execute accurately to obtain the ideal synthesis effect.
What are the physical properties of 2-bromo-4H-furo [3,2-b] pyrrole-5-carboxylic acid
2-Bromo-4H-furano [3,2-b] pyrrole-5-carboxylic acid, this is an organic compound. Its physical properties contain a variety of characteristics.
Looking at its appearance, it is often in a solid state, but the exact color varies depending on the purity and preparation method, or it is a white powder, or it has a slightly yellowish color.
When it comes to the melting point, this compound has a specific melting point value, although no specific data are available. The melting point is the inherent property of the compound, which can be used to identify and determine the purity. When heated to this temperature, the compound gradually melts from a solid state to a liquid state, and this process reflects the strength of its intermolecular forces.
In terms of solubility, in common organic solvents, their solubility varies. In polar organic solvents, such as dimethyl sulfoxide (DMSO), or show better solubility, because DMSO has strong polarity, interacts with the polar groups of the compound, causing the molecules to disperse. In non-polar organic solvents, such as n-hexane, the solubility is poor or poor, because its non-polarity is incompatible with the polar structure of the compound.
In water, because the molecule contains polar groups such as carboxyl groups, it may have a certain solubility, but due to the influence of non-polar parts such as furan and pyrrole rings, the solubility may be limited. < Br >
In addition, its density is also an important physical property. Although the specific value is not detailed, it is related to other physical properties and affects its sedimentation and delamination in the mixture.
Furthermore, the stability of this compound is also key. Under normal conditions, or with a certain stability, the molecular structure may change under specific conditions such as strong acid, strong base, high temperature, and light. For example, in a strong base environment, carboxyl groups or salt, bromine atoms may undergo substitution and other reactions, which affect their chemical and physical properties.
Where is 2-bromo-4H-furo [3,2-b] pyrrole-5-carboxylic acid used?
2-Bromo-4H-furo [3,2-b] pyrrole-5-carboxylic acid (2-bromo-4H-furo [3,2-b] pyrrole-5-carboxylic acid) is a unique organic compound that has its uses in many fields.
In the field of medicinal chemistry, such nitrogen-containing heterocyclic carboxylic acid compounds often have potential biological activities. Due to the uniqueness of its structure, it may interact with specific targets in organisms, such as binding with the activity check points of certain proteins, affecting the function of proteins, and then exhibiting antibacterial, anti-inflammatory, and anti-tumor effects. Scientists may use this as a starting material and chemically modify it to develop new drugs.
In the field of materials science, this compound may be used to create functional materials. Because its structure contains a conjugated system and specific functional groups, or endows the material with unique optical and electrical properties. For example, it may be introduced into polymer systems to prepare materials with special photoluminescence or electroluminescence properties, which can be used in optoelectronic devices such as organic Light Emitting Diodes (OLEDs).
In the field of organic synthetic chemistry, 2-bromo-4H-furano [3,2-b] pyrrole-5-carboxylic acid is a key intermediate and can participate in various chemical reactions. Its bromine atom and carboxyl group are active functional groups, which can construct more complex organic molecular structures through nucleophilic substitution, esterification, amidation and other reactions, providing the possibility for the synthesis of various natural product analogs or new organic compounds.
What is the market outlook for 2-bromo-4H-furo [3,2-b] pyrrole-5-carboxylic acid
2-Bromo-4H-furo [3,2-b] pyrrole-5-carboxylic acid, that is, 2-bromo-4H-furano [3,2-b] pyrrole-5-carboxylic acid, has emerged in the field of current pharmaceutical research and organic synthesis, and the prospect is quite promising.
From the perspective of organic synthesis, this compound has a unique structure, furan and pyrrole are conjugated and contain bromine atoms and carboxylic groups, which endow it with diverse reactivity. Bromine atoms can participate in classical reactions of halogenated aromatics, such as Suzuki coupling, Heck reaction, etc., to introduce various functional fragments, expand the complexity of molecular structure, and lay the foundation for the creation of novel organic materials and bioactive molecules. The carboxyl group is active in nature, and can construct different derivatives through esterification and amidation reactions. It has strong flexibility in the design of organic synthesis routes. Chemists can use this to build a library of rich compounds to meet the diverse needs of drug screening and material research and development.
In the field of drug development, compounds containing furan and pyrrole structural units often have good biological activity. 2-Bromo-4H-furano [3,2-b] pyrrole-5-carboxylic acid, as a key intermediate, can be derived with potential lead compounds through structural modification and optimization. Studies have shown that similar structures exhibit certain activities in anti-tumor, antibacterial, anti-inflammatory, etc. Researchers are expected to modify the surrounding structure of bromine atoms and carboxyl groups, regulate the interaction between compounds and biological targets, improve activity and selectivity, and develop new therapeutic drugs.
Although the current commercial application of 2-bromo-4H-furano [3,2-b] pyrrole-5-carboxylic acid may be limited by the cost and scale of synthesis, with the improvement of synthesis technology, cost reduction and yield improvement can be expected. By then, its application in organic synthesis and drug research and development will be more extensive and in-depth, and it will play an important role in the process of multi-disciplinary integration and development of materials science and medicinal chemistry, and contribute to the emergence of innovative achievements.