2-acetyl-1-ethylpyrrole

2-Acetyl-1-ethylpyrrole is an organic compound that has important uses in many fields.
In the field of medicine, it can act as a key intermediate for the synthesis of drug molecules with specific biological activities. The structural characteristics of this compound give it the potential to interact with targets in vivo, or to participate in the regulation of disease-related physiological processes. For example, researchers can design targeted drugs for specific diseases (such as cancer, inflammation, etc.) by modifying and optimizing their structures, and achieve the purpose of treating diseases by precisely acting on diseased cells or related signaling pathways.
In the field of materials science, 2-acetyl-1-ethylpyrrole also has unique applications. Due to its specific electronic structure and chemical properties, it can be used to prepare functional materials. For example, it can be introduced into polymer systems to improve the electrical and optical properties of materials, or to enhance the stability and mechanical properties of materials. The resulting materials may be applied to electronic devices, optical sensors, and many other aspects.
In the field of organic synthesis, it is an extremely important synthetic building block. Chemists can use its active functional groups to construct more complex organic molecular structures through a series of organic reactions, such as nucleophilic substitution, addition reactions, etc. This is crucial for expanding the structural diversity of organic compounds and synthesizing new organic functional materials and bioactive molecules. A series of organic compounds with different structures and functions can be synthesized efficiently with 2-acetyl-1-ethylpyrrole as the starting material by rationally designing the reaction route.

2-Acetyl-1-ethylpyrrole is an organic compound with unique physical properties. Its shape is liquid or solid, depending on the temperature environment. Under normal circumstances, it is a colorless to light yellow liquid, with a clear and transparent appearance, a texture like water, and good flow properties.
Look at its color, colorless to light yellow, which is caused by the molecular structure and electronic transition characteristics. Under light, or due to differences in light absorption and reflection of different wavelengths, it appears in such a color.
Smell its smell, with a weak special aromatic smell. This smell comes from the combination of specific atoms and groups in the molecular structure, which causes some of its volatile molecules to stimulate olfactory receptors, resulting in this unique smell. < Br >
When it comes to melting and boiling points, the melting point is about -10 ° C to 10 ° C, and the boiling point is about 260 ° C to 270 ° C. This is due to the combination of intermolecular forces, including van der Waals forces and hydrogen bonds. The strength of the intermolecular forces determines the energy required for a substance to transform from a solid state to a liquid state, and from a liquid state to a gaseous state, namely the melting point and boiling point.
Its density is about 1.05 g/cm ³, which is slightly heavier than water. This is due to the type, number and spatial arrangement of atoms in the molecule, resulting in relatively large mass per unit volume.
In terms of solubility, it is slightly soluble in water and soluble in organic solvents such as ethanol and ether. This is because its molecules have a certain hydrophobicity, water is a polar solvent, while the polarity of 2-acetyl-1-ethylpyrrole molecules is relatively weak, so the solubility in water is limited; while the polarity of organic solvents such as ethanol and ether is similar to the compound, and according to the principle of similar compatibility, they are mutually soluble.

2-Acetyl-1-ethylpyrrole is one of the organic compounds. The stability of its chemical properties depends on many factors and cannot be generalized.
In this compound, the pyrrole ring has certain aromaticity, but the lone pair electrons on the nitrogen atom participate in the conjugation system, resulting in a different electron cloud density distribution of the pyrrole ring. The ethyl group at 1-position, as the power supply group, can increase the electron cloud density on the ring, which has a certain impact on the stability. The acetyl group at 2-position has both the electron-absorbing effect of the carbonyl group and the effect of conjugation with the pyrrole ring. These two effects check and balance each other and affect the electron cloud distribution and stability of the compound.
Under normal conditions, 2-acetyl-1-ethylpyrrole is relatively stable. When exposed to strong acids, strong bases or strong oxidants, the stability may be destroyed. Under strong acids, the nitrogen atom or proton of the pyrrole ring destroys the conjugate system and causes structural changes. Strong bases may cause reactions such as nucleophilic substitution to attack specific positions on the acetyl or pyrrole ring. Strong oxidants can oxidize the carbonyl or pyrrole ring of the acetyl group, causing structural changes.
Temperature also affects its stability. At high temperatures, the thermal motion of molecules intensifies, the energy of chemical bonds increases, or the bond breaks and rearrangements are triggered, resulting in reduced stability.
The solvent environment is also important. In polar solvents, molecules interact with solvents or change their electron cloud distribution, which affects stability. Non-polar solvents may have limited solubility, which affects the mode of intermolecular interaction and indirectly affects stability.
Therefore, the stability of 2-acetyl-1-ethylpyrrole depends on the specific environment and conditions. It is relatively stable under specific mild conditions, but in case of extreme chemical conditions, high temperature or special solvent environment, the stability may be greatly affected.

To prepare 2-acetyl-1-ethylpyrrole, there are many methods, which are described in detail below.
First, it can be obtained by reacting 1-ethylpyrrole with acetic anhydride under the action of a suitable catalyst. In this reaction, the nitrogen atom of 1-ethylpyrrole is nucleophilic, and the carbonyl carbon of acetic anhydride is electrophilic. When the two meet, the nucleophilic reagent attacks the electrophilic center and forms a new bond. Usually Lewis acids such as ZnCl ², AlCl 🥰, etc. can be used as catalysts. Such catalysts can enhance the electrophilicity of carbonyl carbons of acetic anhydride and promote the reaction. At the time of the reaction, 1-ethylpyrrole and acetic anhydride are mixed in an appropriate proportion, a catalyst is added, and the reaction is stirred at a suitable temperature. After the reaction, the pure 2-acetyl-1-ethylpyrrole can be obtained by separation and purification methods, such as distillation, column chromatography, etc.
Second, 1-ethyl-2-methylpyrrole is used as the starting material, and the 2-position methyl is oxidized to a carboxyl group. The commonly used oxidizing agents are KMnO, CrO 🥰, etc. The obtained carboxylic acid derivatives are then esterified with ethanol to form corresponding esters. Subsequently, the ester group is reduced to an alcohol hydroxyl group under the action of a specific reducing agent such as LiAlH, and then oxidized to oxidize the alcohol hydroxyl group to an aldehyde group. Finally, the acetyl group is introduced by the reaction of the aldehyde group with the carbon-containing nucleophile, and then converted through a series of reactions to obtain 2-acetyl-1-ethylpyrrole. Although this route has many steps, the reaction selectivity of each step is higher, and a purer product can be obtained.
Third, using pyridine derivatives as raw materials, ethyl is introduced first through the nucleophilic substitution reaction on the pyridine ring, and then acetyl is introduced at a suitable position. This process requires fine control of the reaction conditions. Due to the electron cloud distribution characteristics of the pyridine ring, the check point and conditions of the nucleophilic substitution reaction need to be carefully selected. For example, the reaction of the pyridine ring with halogenated ethane under specific conditions can be used to introduce ethyl group, and then the acetyl group can be introduced through the reaction with acetyl-related reagents such as acetyl chloride in the presence of appropriate catalysts and bases. After subsequent treatment, the target product can be obtained.
All these methods have their own advantages and disadvantages. In actual synthesis, it is necessary to consider many factors such as the availability of raw materials, the ease of control of reaction conditions, and the purity requirements of the product, and make a careful choice.

The price of 2-acetyl-1-ethylpyrrole is confirmed in Wuwei City. This is a fine chemical, and its price often varies depending on purity, supply and demand, and purchase quantity.
If you want high purity, you need more for less supply, and the price must be high; the purchase quantity is huge, or there may be a discount. Its production requires specific processes and raw materials, and the cost also affects the selling price.
In the past, such fine compounds were often expensive due to difficulty in synthesis and expensive raw materials. However, with the advance of science and technology, the synthesis method is good, and the cost or reduction, the price is also different from in the past.
There may be suppliers in the market who sell by the gram, the price may be tens to hundreds of yuan per gram; if the industrial use is purchased in large quantities, the price per kilogram may be hundreds to thousands of yuan in terms of kilograms. But this is all speculation. To know the exact price, you should consult the chemical raw material supplier, chemical reagent dealer, or the chemical product trading platform to get the near-real price.