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What are the main uses of 2,4-bis (4- (tert-butyl) phenyl) -1H-pyrrole?
2% 2C4-bis (4- (butylamino) phenyl) -1H-imidazole has a wide range of uses. In the field of medicine, it is often used as an intermediate in drug synthesis. Due to its unique chemical structure, it can interact with specific biomolecules to help develop new drugs and has potential efficacy in the treatment of certain diseases.
In the field of materials science, it can participate in the preparation of high-performance materials. After rational design and reaction, its introduction into the material system can improve the properties of materials such as optics and electricity, and contribute to the creation of new functional materials.
As an important organic compound in scientific research and exploration, it provides a key foundation for the study of organic synthetic chemistry. Through the investigation of its reaction characteristics and structural modification, researchers can expand the boundaries of organic chemistry knowledge and promote the development of related disciplines.
In summary, 2% 2C4-bis (4- (butylamino) phenyl) -1H-imidazole plays an important role in many fields such as medicine, materials and scientific research, and has high application value and research significance.
What are the synthesis methods of 2,4-bis (4- (tert-butyl) phenyl) -1H-pyrrole?
The synthesis method of 2% 2C4-bis (4- (tert-butyl) phenyl) -1H-imidazole has been recorded in many books, and this is a detailed description for you.
One method is to react the corresponding halogenated aromatic hydrocarbon with tert-butyl phenylboronic acid in a suitable solvent according to the Suzuki coupling reaction method in the presence of palladium catalyst, base and ligand. The reaction conditions are mild and the selectivity is quite good, which can effectively construct carbon-carbon bonds, and then obtain key intermediates. Then, this intermediate and imidazole compounds, under appropriate reaction conditions, through condensation and other reactions, can obtain the target product 2% 2C4-bis (4- (tert-butyl) phenyl) -1H-imidazole.
Another method is to use acetophenone derivatives as starting materials through a series of substitution and cyclization reactions. First, tert-butyl is introduced into the benzene ring of acetophenone, and then under specific conditions, it undergoes cyclization reaction with nitrogen-containing compounds to construct an imidazole ring. Although this path is a little complicated, the raw materials used are more common and the cost can be controlled.
Another synthesis method using metal-organic frameworks (MOFs) as catalysts. Due to its unique structure and catalytic activity, MOFs can promote the reaction. In this synthesis, MOFs can effectively adsorb the reactants, enhance the interaction between molecules, make the reaction more likely to occur, and the reaction conditions are relatively green and environmentally friendly.
Furthermore, microwave-assisted synthesis is also a useful strategy. Under microwave radiation, the reaction system can be rapidly heated, the molecular movement is intensified, the reaction rate is greatly increased, and the occurrence of side reactions can be reduced. With appropriate reactants, under the action of microwaves, and according to reasonable reaction steps, 2% 2C4-bis (4- (tert-butyl) phenyl) -1H-imidazole can be efficiently synthesized.
All synthesis methods have their own advantages and disadvantages. It is necessary to consider many factors such as raw material cost, reaction conditions, yield and purity according to actual needs, and choose carefully to achieve the ideal synthesis effect.
What are the physical properties of 2,4-bis (4- (tert-butyl) phenyl) -1H-pyrrole?
2% 2C4-bis (4- (tert-butyl) phenyl) -1H-imidazole, this is an organic compound. Its physical properties are as follows:
Under normal temperature and pressure, it often shows a white to light yellow crystalline powder state. This morphology is conducive to observation and processing. It is easy to obtain and measure in many experiments and industrial operations.
When it comes to the melting point, it is about 150-160 ° C. The characteristics of the melting point are of great significance for the identification and purity judgment of the substance. If the purity is high, the melting point range is narrow and approaches the theoretical value; if it contains impurities, the melting point is reduced and the range is widened. The specific melting point of this compound can be used as an important indicator in the synthesis and purification process, which can help the experimenter control the reaction process and product quality.
In terms of solubility, it is slightly soluble in water. Water is a common solvent. This property indicates that the force between the compound and water molecules is weak, making it difficult to form a uniform dispersion system. However, it is soluble in common organic solvents, such as toluene, dichloromethane, etc. The good solubility in organic solvents makes it easy to disperse and participate in reactions in organic synthesis, laying the foundation for its application in the field of organic chemistry. For example, when preparing some functional materials or pharmaceutical intermediates, its solubility in organic solvents can be used to achieve full contact and reaction with other reactants.
Furthermore, it has a certain thermal stability. Under moderate heating conditions, the structure and properties can remain relatively stable, preventing rapid decomposition or qualitative change. This thermal stability is of great significance in high temperature processing or application scenarios, such as in the processing of materials, if high temperature treatment is required, the compound can withstand a certain temperature to maintain its own structure and properties, ensuring the quality and performance of the final product.
What are the chemical properties of 2,4-bis (4- (tert-butyl) phenyl) -1H-pyrrole?
2% 2C4-bis (4- (tert-butyl) phenyl) -1H-imidazole, this is an organic compound. Its chemical properties are quite unique, let me tell them one by one.
First of all, from the perspective of its structure, the molecule contains an imidazole ring, which has certain aromaticity, so that the compound has certain stability. And the ring is connected with two 4- (tert-butyl) phenyl groups, tert-butyl is a large substituent, with steric hindrance effect.
In terms of physical properties, due to its large aryl group and tert-butyl group, the relative molecular weight is large, and the intermolecular force is enhanced, so the melting point, boiling point or higher than some simple imidazole derivatives.
In terms of chemical activity, the nitrogen atom of the imidazole ring has a lone pair of electrons, which can be used as an electron donor to participate in the coordination chemical process and form complexes with metal ions. At the same time, the nitrogen atom also makes the ring alkaline and can react with acids to form salts. On the aromatic ring, the electron cloud density of the benzene ring will increase due to the t-butyl as the power supply group. In the electrophilic substitution reaction, such reactions are more likely to occur, and the reaction check point may be affected by the positioning effect of t-butyl, which mostly occurs in the adjacent and para-position of the benzene ring.
And due to the steric resistance of t-butyl, in some reactions, it will hinder the reaction reagents from approaching the imidazole ring or benzene ring, affecting the reaction rate and selectivity. This compound may have potential applications in the fields of materials science, medicinal chemistry, etc., such as for the preparation of new functional materials, which endow the materials with special properties by their unique structure and properties; in medicinal chemistry, it may be used as a lead compound to develop drugs with specific biological activities through structural modification
What is the market price of 2,4-bis (4- (tert-butyl) phenyl) -1H-pyrrole?
I look at your words and inquire about the market price of "2,4-bis (4- (tert-butyl) phenyl) -1H-imidazole". However, the price of this product often changes due to many factors, and it is difficult to determine it suddenly.
First, the price of raw materials affects its cost. The price of tert-butylbenzene and other raw materials fluctuates due to the trend of output, supply and demand. If the raw materials are abundant and the supply exceeds the demand, the price may drop; on the contrary, if the raw materials are scarce and the supply exceeds the demand, the price will rise, which is the fundamental reason.
Second, the preparation technique also has an impact. If the preparation method is exquisite, the yield is high and there are few impurities, the cost is controllable, and the price is stable; if the preparation is difficult, time-consuming and labor-intensive, and the cost is high, the price will also increase.
Third, market supply and demand are the key. If many industries need it, the demand is strong, and the supply is limited, the price will rise; if the demand is low and the supply is sufficient, the price may be reduced to promotion.
Fourth, the difference in region also contributes to the price difference. In different places, the price may vary due to differences in transportation costs, market environment, and policies and regulations.
Therefore, if you want to know the exact price of this product, you should consult chemical raw material suppliers, chemical product trading platforms, or people in related industries. They are able to know the latest price situation due to real-time contact with the market. Although it is difficult for me to tell the price directly, based on the above reasons, you can estimate the approximate range of its price by yourself, and you can get more clarity in the market exploration.