2-(2-nitro-ethyl)pyrrole

2-% 282-nitro-ethyl% 29pyrrole, or 2- (2-nitroethyl) pyrrole, is widely used. In the field of organic synthesis, it is often used as a key intermediate. Gein pyrrole rings have unique electronic structures and reactivity. 2- (2-nitroethyl) pyrrole can be derived from a variety of chemical reactions, such as nucleophilic substitution, reduction and cyclization. Many organic compounds with specific functions and structures are of great significance in the fields of medicinal chemistry and materials science.
In the direction of drug development, studies have found that compounds containing pyrrole structures are often biologically active. 2 - (2 -nitroethyl) pyrrole has been chemically modified and modified, and may be able to construct drug molecules with high affinity with targets in vivo, as potential therapeutic drugs for the fight against a variety of diseases.
In the field of materials science, this material can be used as a raw material for polymerization or compositing with other materials, or new materials with special electrical, optical or mechanical properties can be prepared. For example, it may participate in the preparation of conductive polymer materials, which can be used in the field of electronic devices by the synergistic effect of nitro and pyrrole rings to regulate the electrical conductivity of materials.
In addition, in the preparation of fine chemical products, 2- (2-nitroethyl) pyrrole can be used as a raw material for the synthesis of fine chemicals such as special fragrances and dyes, and its structure endows the products with unique properties and qualities.

2-% 282 - nitro - ethyl% 29pyrrole, that is, 2 - (2 - nitroethyl) pyrrole, the physical properties of this substance are as follows:
Looking at its shape, under normal temperature and pressure, it is mostly in the shape of a liquid state. The color is clear or slightly yellowish, and it can change subtly depending on environmental factors. Its taste is specific, although it is not pungent or intolerable, it is also unique. In a specific space, its unique smell can be felt.
On its melting and boiling point, the melting point is about -10 ° C to -5 ° C, and the boiling point is in the range of 240 ° C to 250 ° C. Such a melting and boiling point indicates that it can maintain a liquid state under normal temperatures. The temperature rises to near the boiling point, and it turns into a gaseous state.
In terms of solubility, 2 - (2 - nitroethyl) pyrrole has good solubility in organic solvents such as ethanol, ether, and dichloromethane. This is because the molecular structure and organic solvents are compatible with each other and follow the principle of similar compatibility. However, in water, the solubility is quite low, because the force between water molecules and the compound molecules is weak, it is difficult to disperse it uniformly.
The density is slightly larger than that of water, about 1.2-1.3g/cm ³. If it is placed in the same container as water, it can be seen that it sinks to the bottom of the water, and the two boundaries are clear.
In addition, the refractive index of 2 - (2 - nitroethyl) pyrrole is about 1.52 - 1.54, which can help to identify this substance and reflect its influence on the direction of light propagation. It is of great significance in optical related research and applications.

2-% 282-nitro-ethyl% 29pyrrole, that is, 2- (2-nitroethyl) pyrrole, is an organic compound. Its chemical properties are interesting and of important research value.
Looking at its structure, the nitrogen atom of the pyrrole ring is electron-rich and has a certain nucleophilicity. The 2-position connected (2-nitroethyl) has a great influence on the electron cloud distribution of the pyrrole ring due to the strong electron-absorbing action of the nitro group. This structural property makes the chemical reactivity of the compound unique.
When it comes to acidity and alkalinity, the lone pair electron of the pyrrole nitrogen atom participates in the conjugated system, which weakens its basicity and increases its acidity slightly. Under specific conditions, it can interact with strong bases, deprotonate nitrogen atoms, and generate corresponding salts.
In electrophilic substitution reactions, due to the high density of pyrrole ring electron clouds, it is vulnerable to electrophilic attack. However, the electron-absorbing effect of (2-nitroethyl) will make the reactivity slightly different from that of pyrrole itself, substituting the check point or preferring the area with relatively high electron cloud density.
In reduction reactions, nitro groups can be reduced, depending on the reducing agent used and the reaction conditions, or amino groups are formed, or other reduced nitrogen-containing groups are obtained, which is an important path for the construction of new compounds.
In addition, the chemical properties of 2 - (2 - nitroethyl) pyrrole may vary depending on the reaction environment, such as solvents, temperatures, catalysts, etc. Understanding and mastering its chemical properties is of great significance to the fields of organic synthesis, drug research and development, and helps researchers design and prepare more valuable compounds.

To prepare 2 - (2 - nitro - ethyl) pyrrole, there are various methods. First, pyrrole can be reacted with 2 - nitroethanol under appropriate conditions with a specific catalyst. Among them, it is quite important to choose a suitable solvent, which can affect the reaction rate and yield. Commonly used solvents, such as dichloromethane, N, N - dimethylformamide, etc., each have their own characteristics and must be selected according to the specific situation of the reaction.
Or pyrrole can be pretreated to make its activity easier, and then it can be combined with a nitro-containing hydrocarbyl reagent. In this process, the ratio of reagents, reaction temperature and time are all critical. If the temperature is too low, the reaction is slow and difficult to achieve full power; if the temperature is too high, side reactions may occur, resulting in impure products.
Furthermore, it can be achieved by a multi-step reaction. First, pyrrole is reacted through a series of reactions to form an intermediate product. This intermediate product has a more suitable reactive group, and then reacts with a raw material containing a 2-nitro-ethyl structure. During this time, the conditions of each step of the reaction, such as pH and the amount of catalyst, need to be fine-tuned to obtain the target product 2 - (2-nitro-ethyl) pyrrole. And after each step of the reaction, the separation and purification of the product cannot be ignored. Silica gel column chromatography and recrystallization can be used to remove impurities and improve the purity of the product.

There is a question today, what is the price range of 2- (2-nitro-ethyl) pyrrole in the market. This is a fine chemical, but I do not know its exact price. Its price is often caused by a variety of changes.
Looking at the price of various things in the past, one is related to the manufacturing cost. If the price of the raw material is high, and the synthesis method is difficult, it requires many steps, many reagents and energy consumption, then the manufacturing cost will be high, and the price will also rise. The raw material of 2- (2-nitro-ethyl) pyrrole may be difficult to find and expensive, and the synthesis may require exquisite technology, which can increase the cost and then cause its price to rise. < Br >
Second, the market supply and demand situation is also serious. If at a certain time, many industries seek this product for research and production in the fields of medicine, materials, etc., there will be a large number of people who need it, and the supply is limited, and the price will tend to rise. On the contrary, if there are few people who want it, the supply will exceed the demand, and the price will drop.
Third, quality and purity also affect the price. High-purity 2- (2-nitro-ethyl) pyrrole is suitable for high-end scientific research and special manufacturing, and its price should be higher than that of ordinary purity.
In summary, it is difficult to determine the price of 2 - (2 - nitro - ethyl) pyrrole without knowing all the details of the current market. For details, you can consult chemical raw material suppliers, traders, or check on relevant chemical trading platforms to get a near real-time price range.