1H-Pyrrole-3-methanamine,5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)

This is a 1H-pyrrole-3-methylamine derivative with a complex chemical formula and many substituents. There is a 2-fluorophenyl group at the 5th position, a methyl group at the N atom, and a 3-pyridyl sulfonyl group at the 1st position. This compound has a unique structure, and the position and connection method of each group determine its characteristics. Specific groups such as fluorophenyl and pyridyl sulfonyl affect its physical, chemical and biological activities. This structure may be of key significance in the field of organic synthesis and drug development. Different substituents may endow compounds with diverse properties and functions, or become new drug lead compounds, or be key intermediates in organic synthesis. More valuable compounds are derived by chemical modification.

1H-pyrrole-3-methylamine, 5- (2-fluorophenyl) -N-methyl-1- (3-pyridyl sulfonyl) The physical properties of this compound are as follows:
Viewed, it often appears in a solid state, but the specific state also depends on the surrounding environmental conditions, such as temperature and pressure. As for color, or colorless to slightly tinted, this also varies depending on the preparation method and purity.
Smell, no very specific smell, or only a weak smell, not pungent, and not strong odor.
As for the melting point, it is about [X] ° C or so. This value is measured under specific conditions. If the environment changes, the melting point will also shift accordingly. Its boiling point is near [Y] ° C, and the boiling point value is also related to the external pressure. Different pressures have different boiling points.
In terms of solubility, in organic solvents such as ethanol and dichloromethane, it has a certain solubility, and can be dissolved into it to form a uniform solution; however, in water, it is quite difficult to dissolve, only slightly soluble. This is because the molecular structure of the substance contains many hydrophobic groups, so the hydrophilicity is not good, and the interaction with organic solvents is strong. The density of
is about [Z] g/cm ³. This value reflects the mass of its unit volume and is of great significance for considering the state and application scenarios when it is mixed with other substances.
The physical properties of this substance are crucial for its application in chemical, pharmaceutical and other fields. When preparing, separating and storing, it needs to be properly disposed of according to its physical properties to ensure its quality and utility.

1H-pyrrole-3-methylamine, 5- (2-fluorophenyl) -N-methyl-1- (3-pyridyl sulfonyl) This compound is mostly used in the field of medicinal chemistry. It is often used as a key intermediate in the process of new drug development. The unique structure of Gain can be chemically modified to build a variety of compound libraries to find molecules with specific biological activities and pharmacological properties.
In the process of drug synthesis, it can participate in a variety of reactions, such as nucleophilic substitution, coupling, etc. In this way, different functional groups can be introduced to shape complex molecular structures, meet the needs of drug-target fit, and enhance the efficacy of drugs in the treatment of specific diseases.
When exploring new anti-disease drugs, researchers hope to obtain drug candidates with high activity, low toxicity and good pharmacokinetic properties by modifying their structures. For example, for specific tumor cell targets, by adjusting the peripheral substituents of the compound, optimizing the binding mode with the target, or developing new anti-cancer drugs with good efficacy. Or in the development of drugs for neurological diseases, by modifying this compound, it is easier to pass through the blood-brain barrier and improve the therapeutic effect on neurological diseases.

The synthesis of 1H-pyrrole-3-methylamine, 5- (2-fluorophenyl) -N-methyl-1 - (3-pyridyl sulfonyl) is a delicate chemical technique. According to the ancient method, this synthesis path needs to be carried out step by step and carefully.
The initial step should be to find suitable starting materials. 5- (2-fluorophenyl) -1- (3-pyridyl sulfonyl) -1H-pyrrole-3-formic acid and other raw materials can be used as the base. To achieve this, multiple reactions may be required. Under specific reaction conditions, 2-fluorobenzaldehyde and suitable pyrrole derivatives may initiate a condensation reaction and start the process of constructing pyrrole rings. Among these, the choice of reaction temperature and solvent is the key. If the temperature is too high, it may cause frequent side reactions; if the solvent is not appropriate, the reaction rate may be hindered.
When the pyrrole ring is initially formed, a methylamino group needs to be introduced. This step can be achieved by the reaction of acid chloride or acid anhydride with methylamine. The reaction of 5- (2-fluorophenyl) -1- (3-pyridylsulfonyl) -1H-pyrrole-3-formyl chloride with methylamine at low temperature and in the presence of acid binding agents. The nucleophilicity of methylamine will prompt it to attack the carbonyl carbon of acid chloride. After substitution reaction, N-methyl-1H-pyrrole-3-methylamino group is successfully introduced.
The whole process of synthesis, each step of the reaction needs to be strictly monitored. The progress can be observed by thin layer chromatography (TLC) to know whether the reaction is as expected and whether the raw materials are exhausted. The purification of the product is also crucial. Impurities can be removed by column chromatography, recrystallization, etc., to obtain pure 1H-pyrrole-3-methylamine, 5- (2-fluorophenyl) -N-methyl-1- (3-pyridyl sulfonyl). In this way, an exquisite synthesis method is obtained to form this complex organic compound.

1H-pyrrole-3-methylamine, 5- (2-fluorophenyl) -N-methyl-1- (3-pyridyl sulfonyl), the relevant safety precautions for this compound are as follows:
The nature of this compound, or toxic, can be harmful to touch, smell, or eat. When handling this compound, you must strictly follow the procedures and wear protective gear, such as protective clothing, gloves, goggles, and gas masks, to avoid skin, eye, and respiratory damage.
Handle it in a well-ventilated place, preferably in a fume hood, so that harmful gases can be dissipated in time to avoid gathering in the room and harming people. If the compound is accidentally leaked, take measures quickly, collect it, and deal with it according to regulations. Do not let it flow, pollute and the environment.
When storing, choose a cool, dry and well-ventilated place, away from fire and heat sources, and store it separately from oxidants, acids, alkalis, etc., to prevent it from touching and causing danger. When handling, be careful to prevent the package from being damaged and causing the material to leak out.
After using this material, the utensils used must be completely cleaned to prevent the residue from remaining and causing other risks by mistake. Once there is an injury in the handling, such as touching the skin, entering the eyes, inhalation or accidental ingestion, give first aid and seek medical attention immediately. Those who touch the skin, rinse quickly with a lot of water; those who enter the eyes, open the eyelids, buffer with water and seek medical attention; those who inhale, move to a fresh air place, if it is difficult to breathe, apply artificial respiration; those who eat by mistake, do not urge vomiting, and seek medical attention quickly.