1H-Pyrrole-2-carboxylic acid, 5-formyl-, ethyl ester

The chemical structure of 1H-pyrrole-2-carboxylic acid, 5-formyl-ethyl ester is an organic compound with a specific atomic connection and spatial arrangement. In its structure, the pyrrole ring is the core, and this five-element nitrogen-containing heterocycle has a unique electron cloud distribution and chemical activity. At the second position of the pyrrole ring, there is a carboxyl-derived ethyl ester group, namely - COOCH -2 CH, which imparts certain lipophilicity and reactivity to the compound. At the fifth position of the pyrrole ring, there is a formyl-CHO, which has an active carbonyl group and can participate in various chemical reactions, such as nucleophilic addition. Overall, the chemical structure of the compound is composed of pyrrole ring as the skeleton, with different functional groups, and each part affects each other to jointly determine its physical and chemical properties. It may have potential application value in organic synthesis, medicinal chemistry and other fields.

1H-pyrrole-2-carboxylic acid, 5-formyl-, ethyl ester, the physical properties of this substance are as follows:
Its appearance is usually solid, but the specific color state, or due to the preparation and purity of different. Under normal temperature and pressure, it is quite stable, and it may be dangerous when it encounters hot topics, open flames or strong oxidants.
The melting point is a specific temperature range. This value is a key indicator for determining its purity and characteristics. The specific melting point indicates the characteristics of intermolecular forces and crystal structures. The boiling point also has a specific value, reflecting the energy required for the substance to change from liquid to gaseous state. The boiling point depends on the strength of the attractive force between molecules.
In terms of solubility, it may have a certain solubility in organic solvents such as ethanol and dichloromethane. Because its molecular structure contains polar and non-polar parts, it can interact with organic solvents. However, the solubility in water may be limited due to the difference between the overall polarity of the molecule and water.
Density is also an important physical property. Compared with other substances, this value reflects the mass of the substance per unit volume. It is crucial in operations such as substance separation and mixing. The refractive index represents the degree of refraction of light when passing through the substance, which can be used for identification and analysis, and is related to the molecular structure of the substance and the distribution of electron clouds.
The above physical properties are all indispensable factors to consider when studying, preparing and applying this substance, helping researchers to gain insight into its behavior and characteristics, so as to effectively control related chemical processes.

The common synthesis methods of 1H-pyrrole-2-carboxylic acid, 5-formyl-ethyl ester cover the following kinds.
First, the compound containing pyrrole structure is used as the starting material. If a pyrrole derivative is selected, the formyl group is introduced at a specific position first. This step can be achieved by the Vilsmeier-Haack reaction. In this reaction, a suitable reagent combination, such as dimethylformamide (DMF) and phosphorus oxychloride (POCl), interact to form an active electrophilic reagent, and then the electrophilic substitution reaction occurs with the specific position of the pyrrole derivative, and the formyl group is successfully introduced. Then, the ethyl ester group is introduced at the carboxyl group of the pyrrole-2-position through esterification reaction. Ethanol can be reacted with suitable catalysts, such as concentrated sulfuric acid or p-toluenesulfonic acid, under heating conditions to promote the esterification reaction to occur smoothly, and the final target product is 1H-pyrrole-2-carboxylic acid, 5-formyl-, ethyl ester.
Second, you can also start with the construction of pyrrole rings. For example, pyrrole rings are synthesized by Paal-Knorr reaction of 1,4-dicarbonyl compounds with ammonia or its derivatives as raw materials. During the reaction, the 1,4-dicarbonyl compound undergoes condensation and cyclization in the molecule to form a pyrrole ring structure. Then, on the basis of the completion of the construction of the pyrrole ring, according to the above similar method, the formyl group is first introduced, and then the esterification reaction is carried out to gradually obtain the target product. During operation, attention should be paid to the precise control of the reaction conditions, such as temperature, reaction time and reagent dosage, because these factors have a great influence on the reaction process and product yield.
Third, there is a strategy to use aromatic hydrocarbons with suitable substituents as the starting materials and convert them into the target product through multi-step reactions. First, the aromatic hydrocarbons are converted into intermediates containing pyrrole structures through a series of reactions, and then formyl groups and ethyl ester groups are introduced in turn. This route is relatively complicated, but if the reaction of each step can be planned reasonably, the target product 1H-pyrrole-2-carboxylic acid, 5-formyl-ethyl ester with higher yield can also be obtained.

1H-pyrrole-2-carboxylic acid, 5-formyl-, ethyl ester is useful in various fields. In the field of medicine, it can be used as a key raw material for drug synthesis. Its unique chemical structure can endow the drug with specific biological activities, or have antibacterial and antiviral effects, or can be used for the creation of anti-tumor drugs. Its structure interacts with specific targets of cancer cells to inhibit tumor growth.
In the context of materials science, it may be able to participate in the preparation of functional materials. Due to its special functional groups, polymer materials can be chemically modified to improve material properties, such as enhancing the hydrophilicity of materials, improving their mechanical properties, or imparting materials with light and electrical response characteristics, which are used in optoelectronic devices, sensors, etc.
In the field of organic synthesis, it is an important intermediate. Chemists can use its various reaction check points to construct complex organic molecular structures through various organic reactions, providing the possibility for the synthesis of novel organic compounds, promoting the progress of organic chemistry research, enriching the variety of organic compounds, and laying the foundation for subsequent research and application.
In chemical production, or used in the manufacture of fine chemicals. It can generate a range of high-value-added products, enhance the diversity and quality of chemical products, and inject vitality into the development of the chemical industry. It plays an important role in the industrial production chain and has high economic value and application potential.

What you are asking is the market price of "1H - Pyrrole - 2 - carboxylic acid, 5 - formyl -, ethyl ester". However, the market price of this compound often varies for many reasons. The preparation is difficult and easy. If the preparation process is complicated, many steps and special reagents are required, the cost will be high, and the price will also rise. If the raw materials are scarce or rare, the price will be high. If the market demand for this product is strong, the supply will exceed the demand, and the price will also rise. In addition, the competition between suppliers and the market also affects the price.
In the chemical reagent market, the price of such fine chemicals is often not fixed. To know the exact price, you need to consult the chemical reagent supplier. Different suppliers may have different quotations due to cost control and business strategies. You can visit common reagent sales platforms, such as search banner, McLean, etc., to check their quotations, or call the supplier directly to inquire about prices and bulk purchase discounts. In this way, accurate information on their market prices can be obtained.