1h Pyrrole 2 Carboxylic Acid 4 Bromo Ethyl Ester
pyridine pyrrole pyrazine piperidine piperazine

1H-Pyrrole-2-carboxylic acid, 4-bromo-, ethyl ester

    Specifications

    HS Code

    268458

    Chemical Formula C7H8BrNO2
    Molar Mass 218.05 g/mol
    Appearance Solid (usually a white - off - white powder)
    Melting Point Data may vary, typical organic compound melting range
    Boiling Point Data may vary, related to its molecular structure and intermolecular forces
    Solubility Soluble in some organic solvents like dichloromethane, chloroform
    Density Data specific to compound, related to mass and volume relationship
    Flash Point Relevant for handling in case of fire risk, specific value needed
    Refractive Index Value indicating how light is bent when passing through, specific to compound
    Pka Related to its acidic - basic properties in solution, specific value

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    General Information
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    Frequently Asked Questions

    As a leading 1H-Pyrrole-2-carboxylic acid, 4-bromo-, ethyl ester supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 1H-Pyrrole-2-carboxylic acid, 4-bromo-, ethyl ester
    4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester is a kind of organic compound. Its physical properties are as follows:
    Looking at its appearance, it often shows the shape of white to light yellow crystalline powder, which is intuitively recognized by the naked eye. It has a certain melting point, about [X] ° C. The measurement of the melting point is one of the important indicators for the identification of this substance, which can be accurately measured by a melting point meter. In terms of solubility, the substance exhibits good solubility in organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc., but in water, the solubility is quite limited. This property is closely related to the molecular structure of the substance. In its molecular structure, there are both hydrophobic groups and ester groups and other functional groups, which make it dissolve differently in water and organic solvents.
    Under normal temperature and pressure, 4-bromo-1H-pyrrole-2-carboxylate ethyl ester is relatively stable. However, it should be noted that if it is in a special environment such as high temperature, high humidity or light, its stability may be affected. At high temperature, the hydrolysis reaction of ester groups may be triggered, resulting in changes in the molecular structure; light may also trigger some photochemical reactions, resulting in changes in its properties. Therefore, when storing the substance, it should be stored in a cool, dry, and dark place to ensure the stability of its physical and chemical properties and to avoid deterioration due to external factors.
    What is the chemical synthesis method of 1H-Pyrrole-2-carboxylic acid, 4-bromo-, ethyl ester
    The method of preparing 4-bromo-1H-pyrrole-2-carboxylic acid ethyl ester can follow the following steps.
    First take 1H-pyrrole-2-carboxylic acid as the starting material, and place it in a round bottom flask with an appropriate amount of ethanol and concentrated sulfuric acid. Concentrated sulfuric acid is used as a catalyst to promote the esterification reaction of the two. Control the temperature within an appropriate range, and often heat it in an oil or water bath to make the reaction proceed smoothly. During the reaction, pay close attention to temperature changes, and do not cause side reactions to increase if the temperature is too high.
    After the esterification reaction is completed, cool the reaction mixture. Subsequently, the organic phase is separated by a separation funnel and washed with an appropriate amount of saturated sodium carbonate solution to remove unreacted acid and residual sulfuric acid. The organic phase is then washed several times with distilled water to remove residual salts and other impurities.
    After that, the organic phase is dried with anhydrous sodium sulfate to remove residual moisture. After drying, the sodium sulfate is filtered to obtain a filtrate.
    Take this filtrate and separate it by reduced pressure distillation to obtain 1H-pyrrole-2-carboxylate ethyl ester.
    Take this ester and dissolve it in a suitable organic solvent such as dichloromethane. In this solution, slowly add brominating reagents, such as N-bromosuccinimide (NBS). During the reaction, add an appropriate amount of initiator, such as benzoyl peroxide, to initiate the reaction by light or heat. Bromine atoms can selectively replace hydrogen atoms at the 4-position of pyrrole ring to form ethyl 4-bromo-1H-pyrrole-2-carboxylate.
    After the reaction is completed, the product is further purified by column chromatography or recrystallization, and impurities are removed to obtain pure ethyl 4-bromo-1H-pyrrole-2-carboxylate. The operation process must be careful and follow the safety regulations of chemical experiments to ensure the safety of personnel and the environment.
    1H-Pyrrole-2-carboxylic acid, 4-bromo-, ethyl ester in which applications
    4-Bromo-1H-pyrrole-2-carboxylate ethyl ester, which is useful in various fields. In the field of pharmaceutical research and development, it can be a key raw material for the creation of new drugs. The structure of Geinpyrrole is common in many bioactive molecules. The introduction of bromine atoms may endow compounds with unique physical and chemical properties and biological activities, which can help drugs to combine with specific targets, and then open up new ways for disease treatment.
    In the field of organic synthesis, it is an important building block for the construction of complex organic molecules. With the ester group and bromine atoms it contains, it can be connected with other organic fragments through various organic reactions, such as nucleophilic substitution, coupling reaction, etc., to construct complex organic compounds, which contribute to the development of organic synthetic chemistry.
    also has potential applications in materials science. After rational design and modification, materials with special properties, such as optoelectronic materials, may be prepared. Pyrrole-like compounds may exhibit unique optoelectronic properties in optoelectronic devices due to their own electronic structure characteristics, and the special structure of this compound may further optimize material properties, making it popular in electronic devices and other fields.
    What is the market price of 1H-Pyrrole-2-carboxylic acid, 4-bromo-, ethyl ester
    I think what you are asking is about the market price of 1H-pyrrole-2-carboxylic acid, 4-bromo-ethyl ester. However, the market price of this compound is difficult to generalize, because many factors interact.
    First, the state of supply and demand has a huge impact on the price. If the demand for this compound is strong and the supply is limited, the price will increase; conversely, if the supply exceeds the demand, the price will naturally decline. Second, the difficulty of preparation is also the key. If the synthesis requires complicated steps, the raw materials are rare and expensive, or the reaction conditions are harsh, the production cost will be high, resulting in a high market price. Third, the situation of market competition cannot be ignored. If there are many congeneric products and merchants compete for profits, the price may be lowered; if there are few competing products in the market and they dominate, the price may remain high.
    And market prices often change dynamically and fluctuate over time. Sometimes due to the rise and fall of raw material prices, sometimes due to easier policies and regulations, and sometimes due to the rise and fall of production efficiency caused by technological progress, prices can vary. Therefore, if you want to know the exact market price of this product, you should carefully check the real-time quotation of the chemical raw material trading platform, or consult the merchants specializing in such chemicals, in order to get a relatively accurate price.
    What are the storage conditions for 1H-Pyrrole-2-carboxylic acid, 4-bromo-, ethyl ester?
    4-Bromo-1H-pyrrole-2-carboxylic acid ethyl ester, this medicine should be placed in a cool and dry place, avoid direct sunlight, to prevent changes in drug properties. The packaging of the medicine needs to be well sealed, so as to isolate the intrusion of external moisture, air and other factors, so that the composition of the medicine can remain stable.
    When storing, the temperature is also very critical. It should be stored in a place with a relatively constant temperature, and it should not be exposed to large fluctuations in temperature to prevent changes in the internal structure of the medicine and affect the efficacy of the medicine. If the temperature is too high, it may cause the decomposition of drug components; if the temperature is too low, it may also change some properties of the medicine.
    And this medicine should be placed out of the reach of children to avoid accidental ingestion and accidents.
    Also, the storage place should be kept away from fire sources, power sources, etc., for safety. The choice of drug storage environment is related to the survival of the drug effect, and it must not be ignored. It needs to be treated with caution, so as to ensure that the drug can exert its due effect when used.