1H-Pyrrole-1-carboxamide,3-ethyl-2,5-dihydro-4-methyl-2-oxo-N-(2-phenylethyl)

This is the chemical name of "3-ethyl-2,5-dihydro-4-methyl-2-oxo-N - (2-phenethyl) -1H-pyrrole-1-formamide". Its chemical structure is based on a pyrrole ring, with formamide at 1 position, ethyl at 3 position, methyl at 4 position, and carbonyl at 2 position, and the nitrogen atom of the formamide group is connected to 2-phenethyl group. The
pyrrole ring has a five-membered nitrogen-containing heterocyclic structure and is aromatic. Formamido is an amide functional group formed by linking a carbonyl group to an amino group. Ethyl is obtained by removing an alkyl group from a hydrogen atom from ethane, and methyl is obtained by removing a hydrogen atom from methane. 2-Phenethyl is composed of a benzene ring connected to a methylene group and then an ethyl group. The interaction of various groups in the structure of this compound affects its chemical and physical properties. It may have important uses in organic synthesis, medicinal chemistry and other fields, or exhibit specific biological activities and reaction characteristics due to its unique structure.

This is 3-ethyl-2,5-dihydro-4-methyl-2-oxo-N- (2-phenethyl) -1H-pyrrole-1-formamide. Its physical properties are as follows:
This substance is either solid at room temperature and pressure, and it may be white to quasi-white crystalline powder, because this structural feature often has such an appearance. Its melting point or in a specific temperature range, but the exact value needs to be accurately determined by experiments.
In terms of solubility, in organic solvents, or slightly soluble in common petroleum ether, n-hexane and other non-polar solvents, because its molecular structure contains polar parts, the interaction with non-polar solvents is weak. In polar organic solvents such as ethanol and acetone, or have good solubility, because the polar parts of the molecule can form hydrogen bonds or other intermolecular forces with polar solvents. In water, due to the large proportion of the overall hydrophobic part of the molecule, it may be only slightly soluble or even insoluble.
Its density may be different from that of water, or greater than that of water. Due to the combination of the types and quantities of atoms in the molecule, its unit volume mass may be greater than that of water.
In addition, the stability of this substance may be affected by environmental factors. In light, high temperature, high humidity environment, or decomposition reaction occurs, resulting in structural changes and poor stability. However, it is properly stored in a dry, cool, dark place, or can maintain relatively stable structure and properties. Its volatilization property may not be significant, because its structure is relatively stable, the intermolecular force is moderate, and it is not easy to volatilize from solid or liquid to gas phase.

3-Ethyl-2,5-dihydro-4-methyl-2-oxo-N- (2-phenylethyl) -1H-pyrrole-1-formamide is widely used. In the field of medicine, it can be used as a key raw material to develop new drugs for the treatment of specific diseases. Due to its unique structure, it can interact with specific targets in the body, or show good results in the treatment of certain diseases.
In the chemical industry, it can act as an intermediate for the synthesis of special materials. With its own chemical properties, it participates in many complex chemical reactions, and helps to synthesize materials with special properties, such as some polymer materials with special stability or functionality, which contributes to the diversification of chemical products.
At the level of scientific research and exploration, as a new type of compound, it provides a new object for research in the fields of chemistry and biology. Scientists can expand the boundaries of chemical knowledge by studying its properties and reaction mechanisms, explore unknown chemical phenomena and laws, and contribute to the theoretical development of related fields. In conclusion, 3-ethyl-2,5-dihydro-4-methyl-2-oxo-N - (2-phenylethyl) -1H-pyrrole-1-formamide is of great significance in many fields and plays an indispensable role in promoting the development of various fields.

To prepare 3-ethyl-2,5-dihydro-4-methyl-2-oxo-N- (2-phenethyl) -1H-pyrrole-1-formamide, there are many ways to synthesize it.
First, you can start from a suitable pyrrole derivative. First, take a specific pyrrole compound, put it in a suitable reaction vessel, and protect it with an inert gas such as nitrogen to create an oxygen-free environment. Add an appropriate amount of base, such as potassium carbonate, to adjust the pH of the reaction system, which is conducive to the reaction. The addition of ethyl-containing halogenated hydrocarbons, such as bromoethane, is heated and stirred at an appropriate temperature, such as 60-80 ° C. After nucleophilic substitution, ethyl can be introduced at the 3rd position of the pyrrole ring.
Then, for the construction of the 2,5-dihydro-2-oxo structure of the pyrrole ring. The above reaction product is slowly added dropwise under ice bath cooling, and an acid-binding agent such as acetyl chloride is accompanied by triethylamine. This can capture the hydrogen halide generated by the reaction and promote the forward movement of the reaction. After this step, an intermediate product with a 2-oxo structure can be obtained.
As for the introduction of 4-methyl, methylation reagents, such as iodomethane, can be used under strong basic conditions, such as the presence of sodium hydride, in a suitable organic solvent such as tetrahydrofuran, heating reaction, so that methyl successfully attached to the fourth position of the pyrrole ring.
Finally construct N - (2-phenethyl) structure. The aforementioned product is mixed with 2-phenethylamine, and in the presence of a condensing agent such as dicyclohexyl carbodiimide (DCC) and a catalyst such as 4-dimethylaminopyridine (DMAP), in a solvent such as dichloromethane, stirred at room temperature. After amidation, the final product is 3-ethyl-2,5-dihydro-4-methyl-2-oxo-N - (2-phenethyl) -1H-pyrrole-1-formamide. In the process of synthesis, it is necessary to pay attention to the precise control of the conditions of each step of the reaction, such as temperature, reagent dosage, reaction time, etc., and the product after each step of the reaction needs to be properly separated and purified to ensure the purity and yield of the final product.

This is a 1H-pyrrole-1-formamide compound with the chemical name 3-ethyl-2,5-dihydro-4-methyl-2-oxo-N - (2-phenethyl). Regarding the safety of this substance, although there is no direct record in ancient books, it can be briefly inferred from the scientific perspective and the regularity of similar substances today.
Looking at its chemical structure, it contains specific groups, or has certain reactivity. Organic amides are often involved in biological activity, and some of these substances may interfere with physiological processes due to structural fit with molecules in organisms. In this compound, ethyl, methyl, phenethyl and other hydrocarbon groups affect its fat solubility, or easily penetrate the biofilm, increasing the chance of interacting with biological macromolecules.
In terms of toxicity, or due to binding with proteins, nucleic acids, etc., disrupt the normal metabolism of cells. Some contain similar structural substances, which can cause damage to the liver, kidneys and other organs in animal experiments. Because of its metabolic transformation to produce active intermediates, it covalently binds with cellular components. However, the specific toxicity of this compound needs to be confirmed by experiments.
In terms of environmental safety, if released into the environment, its fat solubility or accumulation in organisms will be enriched through the food chain. And because of its chemical stability, or difficult to rapidly degrade, it persists in the environment for a long time, affecting the ecological balance.
Although there is no exact ancient conclusion, with modern scientific reasoning, this compound needs to be treated with caution. Experiments are conducted to clarify its safety and prevent potential hazards.