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What are the physical properties of 1- (p-tolylsulfonyl) -2,5-dihydropyrrole?
1- (p-toluenesulfonyl) -2,5-dihydropyrrole, this is a class of compounds in the field of organic chemistry. Its physical properties are quite critical and are related to many practical applications.
The first to bear the brunt, the melting point and boiling point characteristics of this substance are remarkable. The melting point is the temperature at which the substance changes from solid to liquid. After careful study, 1- (p-toluenesulfonyl) -2,5-dihydropyrrole has a specific melting point. At this temperature, its lattice structure disintegrates and the molecules are able to move in a more free state. The same is true for boiling points. Under a specific pressure environment, the temperature at which the substance converts from liquid to gas. This kind of data provides a key reference for experimental operations, separation and purification processes, just like a river or sea needs to distinguish the wind direction and water flow.
Furthermore, solubility is also an important property. It dissolves differently in various solvents. In organic solvents such as ethanol, ether, etc., according to the principle of similar compatibility, its molecular structure is similar to that of some organic solvents, so it can be dissolved to varying degrees. Or partially dissolved, or completely miscible, this phenomenon provides a broad choice for organic synthesis reactions, just like a craftsman's selector, which is used according to material characteristics. In water, due to the difference between molecular polarity and water, the solubility may not be good, which in turn provides ideas for operations such as separation and recovery.
In addition, the appearance and morphology are also an important part of physical properties. It may be a colorless to light yellow liquid, or a solid powder. The characterization of color and morphology is of great significance in intuitively judging the purity and state of a substance, just like the appearance and complexion of a person, which can be used to judge whether it is healthy or not.
And density, which is the mass per unit volume. Density data of 1- (p-toluenesulfonyl) -2,5-dihydropyrrole are indispensable in scenarios such as mixed system research, mass and volume conversion. It is like a scale for weighing weight and accurately measuring material properties.
In summary, the physical properties of 1- (p-toluenesulfonyl) -2,5-dihydropyrrole, such as melting point, boiling point, solubility, appearance morphology and density, are like the cornerstone of the building of organic chemistry, and are of great value in scientific research and production.
What is the chemical synthesis method of 1- (p-tolylsulfonyl) -2,5-dihydropyrrole?
To prepare 1- (p-toluenesulfonyl) -2,5-dihydropyrrole, the method is as follows:
Pyrrole is often used as the starting material. First, pyrrole reacts with p-toluenesulfonyl chloride in the presence of a suitable base. This base can be triethylamine or the like, and stirred at low temperature in a suitable solvent, such as dichloromethane. The nitrogen atom of pyrrole is nucleophilic and can attack the sulfur atom of p-toluenesulfonyl chloride. The chlorine leaves to form 1- (p-toluenesulfonyl) pyrrole.
Then, 1- (p-toluenesulfonyl) pyrrole is partially hydrogenated to obtain the target product 1- (p-toluenesulfonyl) -2,5-dihydropyrrole. The method of partial hydrogenation can be catalytic hydrogenation. Select a suitable catalyst, such as palladium-carbon catalyst, and react in an alcohol solvent such as methanol under mild hydrogen pressure. By regulating the reaction conditions, such as hydrogen pressure, reaction temperature and time, the pyrrole ring can be partially hydrogenated to form a 2,5-dihydropyrrole structure, resulting in 1- (p-toluenesulfonyl) -2,5-dihydropyrrole. When operating, it is necessary to pay attention to the precise control of reaction conditions and pay attention to safety, as hydrogen is involved.
In which fields is 1- (p-tolylsulfonyl) -2,5-dihydropyrrole used?
1-% (p-tolylsulfonyl) -2,5-dihydropyrrole is one of the organic compounds. It has applications in various fields and is very useful.
In the field of organic synthesis, this compound often acts as a key intermediate. Because of its unique structure, it can be converted into other complex organic molecules through various chemical reactions. If it reacts with nucleophiles, it can form novel carbon-carbon bonds or carbon-heteroatom bonds, which is useful in the synthesis of biologically active natural products and drug molecules. For example, in the synthesis of specific anti-cancer drug intermediates, 1-% (p-tolylsulfonyl) -2,5-dihydropyrrole can be embedded in the target molecular structure through clever reaction steps, laying the foundation for subsequent synthesis.
In the field of materials science, it is also involved. Due to the electronic properties and structural stability of the compound, it may be used to create functional materials. For example, when designing new optoelectronic materials, it can be introduced into the material structure, or the photoelectric properties of the material can be improved, such as improving its absorption and emission efficiency of specific wavelengths of light, and then applied to the research and development of optoelectronic devices such as organic Light Emitting Diodes (OLEDs), promoting progress in display technology and other fields.
In the field of pharmaceutical chemistry, 1-% (p-tolylsulfonyl) -2,5-dihydropyrrole has attracted much attention due to its potential biological activity. Researchers have explored its interaction with targets in vivo by modifying and modifying its structure. Some derivatives may exhibit antimicrobial, anti-inflammatory and other biological activities, providing an opportunity for the development of new drugs, which is expected to develop innovative drugs with better curative effect and less side effects, and benefit human health.
From this perspective, 1-% (p-tolylsulfonyl) -2,5-dihydropyrrole has important applications in organic synthesis, materials science, medicinal chemistry and other fields, providing indispensable support for many research and technological development.
How stable is 1- (p-tolylsulfonyl) -2,5-dihydropyrrole?
1 - (p-toluenesulfonyl) - 2,5 -dihydropyrrole, this is an organic chemical. The study of its stability depends on its structure, environmental conditions and other factors.
In terms of structure, the compound contains a pyrrole ring, and the double bond in the ring endows it with a certain reactivity. The p-toluenesulfonyl group is connected to the pyrrole ring, and this group has an electron-absorbing effect, or affects the electron cloud distribution of the pyrrole ring, which in turn affects the stability. Generally speaking, electron-withdrawing groups can reduce the density of the ring electron cloud, causing its electrophilic reactivity to decrease, but the nucleophilic reactivity may increase.
In terms of environmental conditions, temperature, pH, light, and the presence or absence of catalysts can all affect its stability. At high temperatures, the thermal motion of molecules intensifies, or the vibration of chemical bonds increases. When the energy reaches a certain level, the chemical bonds may break, and the stability is damaged. In a strong acid and alkali environment, it may change its structure due to protonation or deprotonation, and the stability is also affected. Light or luminescent chemical reactions cause chemical bonds to crack or rearrange, which affects the stability. If there is a suitable catalyst, it may also catalyze its reaction, reducing the stability.
If properly stored, placed in a low temperature, dark, neutral or near neutral environment, and avoid contact with active reagents, this compound may maintain a certain stability. However, once the environment changes, or under specific reaction conditions, it may exhibit reactivity, and various reactions occur, the stability will change accordingly.
What is the market price of 1- (p-tolylsulfonyl) -2,5-dihydropyrrole?
1-%28p-tolylsulfonyl%29-2%2C5-dihydropyrrole is an organic compound, but its market price varies due to a variety of factors, making it difficult to determine the value.
First, the quality has a great impact on the price. High purity, less impurities, good reaction effect, large demand in scientific research and high-end production fields, and the price is high; low purity, containing more impurities, or affecting the use, the price is low.
Second, the purchase quantity also affects the price. When purchasing in large quantities, suppliers may give discounts due to economies of scale, and the unit price is reduced; when purchasing in small quantities, the unit price is often high due to relatively high transaction costs.
Third, the market supply and demand relationship plays a significant role. If the demand for this compound is strong and the supply is tight, the price will rise; if the demand is small and the supply is large, the price will easily fall.
Fourth, different suppliers have different pricing strategies. Those with strong strength, excellent cost control, and wide channels may have competitive prices; those who are new to the market or have high operating costs may have slightly higher prices.
Usually in the chemical raw material market, the price fluctuates greatly. In the scientific research reagent market, the price of small-packaged high-purity products may be high; in the large-scale chemical production raw material market, the price may change significantly due to different batches. If you want to know the exact price, you can consult chemical product suppliers, traders, or check the quotation of professional chemical product trading platforms to obtain accurate price information.