1-O-tert-butyl 2-O-methyl (2S)-2,5-dihydropyrrole-1,2-dicarboxylate

1-O-tert-butyl-2-O-methyl- (2S) -2,5-dihydropyrrole-1,2-dicarboxylate is widely used in the field of organic synthesis.
It can be used as a key building block in the construction of complex organic molecular structures. Due to its unique chemical structure, it can exhibit special activities in many reactions. For example, in some cyclization reactions, the properties of its own dihydropyrrole ring and ester group can guide the reaction in a specific direction, assisting chemists to construct complex compounds containing pyrrole rings, which are often found in natural products and bioactive molecules.
Furthermore, in the field of asymmetric synthesis, the (2S) configuration of this compound endows it with chiral properties. Chirality is crucial in drug synthesis and other aspects, because it can induce reactions to generate products of specific configurations, thereby enhancing the activity and selectivity of drugs. For example, in asymmetric catalytic reactions, it can act as a chiral adjuvant and cooperate with catalysts to promote the reaction to generate the desired chiral products efficiently and selectively, providing an important raw material for the development of new chiral drugs.
In addition, in the field of materials science, this compound can be suitably modified and polymerized to form polymeric materials with special properties. The ester group can participate in the polymerization reaction to build a polymer structure, while the dihydropyrrole ring may impart specific optical and electrical properties to the material, such as for the preparation of organic materials with special optoelectronic properties, which are used in the field of optoelectronic devices.

The synthesis method of 1-O-tert-butyl + 2-O-methyl + (2S) -2,5-dihydropyrrole-1,2-dicarboxylate has various paths.
First, it can be started by a suitable pyrrole derivative. Find a pyrrole with a modifiable group, use tert-butyl alcohol and the corresponding activation reagent, and under appropriate conditions, connect the 1-position oxygen of pyrrole to the tert-butyl group. In this case, the catalysis of a basic agent may be required to help it form bonds. Then, the methylation reagent, such as iodomethane, is used to bind the 2-position oxygen to the methyl group in a suitable solvent and an alkaline environment, and the target product is finally obtained through a series of reactions.
Second, you can start from a simple carboxylic acid ester. Select the appropriate dicarboxylic acid ester, first introduce the chiral center at one end to shape the (2S) configuration, and then connect the 1-position to the tert-butyl group and the 2-position to the methyl group in turn. This process requires fine control of the reaction conditions, such as temperature, reaction duration, and reagent ratio, to ensure the selectivity and yield of the reaction.
Third, it can also be achieved by cyclization reaction. Using chain-like compounds containing specific functional groups as raw materials, under suitable catalyst and reaction conditions, intramolecular cyclization occurs to construct dihydropyrrole rings, and tert-butyl and methyl are introduced at the 1st and 2nd positions at the same time. This approach requires quite high requirements for raw material design and reaction conditions, but if successful, it may have the advantage of high efficiency.
All kinds of synthesis methods have their advantages and disadvantages. Experimenters need to weigh and choose according to many factors such as raw material availability, cost, and reaction difficulty. Only by careful implementation can 1-O-tert-butyl + 2-O-methyl + (2S) -2,5-dihydropyrrole-1,2-dicarboxylate be synthesized efficiently.

1-O-tert-butyl-2-O-methyl- (2S) -2,5-dihydropyrrole-1,2-dicarboxylate, this is an organic compound. Its physical properties are quite critical and are of great significance in chemical research and related application fields.
Looking at its properties, it is mostly colorless to light yellow liquid under normal circumstances, with uniform and clear texture, like a quiet pool water, with invisible impurities or suspended solids, showing a pure state. < Br >
When it comes to the melting point, the melting point of this compound is relatively low, between -20 ° C and -10 ° C. It is like thin ice that is easy to melt under the warm sun in winter. When the temperature increases slightly, it will quietly transform from solid to liquid.
In terms of boiling point, it is about 230 ° C to 240 ° C. Under specific temperature conditions, its molecules can break free from the liquid phase and turn into gaseous ascension.
Solubility is also an important property. It is soluble in common organic solvents, such as dichloromethane, chloroform, ether, etc., and naturally fuses like fish entering water. It exhibits good solubility in these solvents, but it has little solubility in water, just like oil and water. It is difficult to blend, and its molecular structure makes it less hydrophilic.
The density is about 1.10-1.15 g/cm ³, which is slightly heavier than water. If it is placed in the same container as water, it will settle below like a stone sinking to the bottom.
In addition, the refractive index of this compound also has a specific value, about 1.480-1.490. When light passes through this substance, it will be refracted at a specific angle. This property may be used as a basis for identification and identification in optical related research and analysis.
The physical properties of this compound are like its unique "identity", which lays the foundation for its application in many fields such as organic synthesis and drug development. According to its properties, researchers can precisely design experiments to achieve the expected chemical reactions and application goals.

The chemical stability of 1-O-tert-butyl + 2-O-methyl + (2S) -2,5-dihydropyrrole-1,2-dicarboxylate is related to the resistance and survival of various chemical changes.
Looking at its structure, tert-butyl has a steric resistance, which can protect ortho-ester groups and increase the stability of molecules in specific environments. The presence of methyl groups affects molecular polarity and electron cloud distribution, and also plays a role in stability.
From the theory of reactivity, the double bond in the 2,5-dihydropyrrole ring has reactivity such as electrophilic addition, but the surrounding ester groups and substituents may inhibit or guide specific reaction pathways, preventing random reactions, and maintaining its stability to a certain extent.
In common chemical environments, if the temperature is not too high, there are no extreme conditions such as strong acids and bases and strong oxidants, its structure can be relatively stable. In case of strong acids, ester groups or hydrolysis; in case of high temperatures and strong oxidants, double bonds and ester groups may be damaged. In conclusion, the chemical stability of 1-O-tert-butyl + 2-O-methyl + (2S) -2,5-dihydropyrrole-1,2-dicarboxylate is relatively stable under normal conditions based on its structural characteristics, but it is variable under special chemical reactions.

The price of 1-O-tert-butyl+2-O-methyl+ (2S) -2,5-dihydropyrrole-1,2-dicarboxylate in the city is difficult to determine. The price of this product depends on many factors.
First, the source and quality of the material. If the raw materials are easy to harvest and of good quality, the cost of production may decrease, and the price will also decrease; on the contrary, if the raw materials are rare or of poor quality, the price will increase.
Second, the methods of preparation are different. The method of preparation is simple, labor-saving and time-saving, and the cost is reduced and the price is appropriate; if the method is difficult, high-precision techniques and tools are required, and the cost will increase and the price will be high.
Third, the supply and demand of the city are also the main reasons. < Br >
Fourth, the difference between the rules of trade and the land also has an impact. Taxes, freight, etc. vary, resulting in different prices in different places.
To sum up, if you want to know the exact price of this thing, you should carefully examine the raw materials, production methods, supply and demand, and trade conditions. Now only according to the name mentioned, it is difficult to determine the scope of its price.