1-METHYLPYRROLE-2-ACETIC ACID METHYL ESTER

1-Methyl pyrrole-2-acetate, this is an organic compound. Its shape may be colorless to light yellow liquid with a specific odor.
In terms of physical properties, its boiling point, melting point, density and other properties are determined by intermolecular forces and structures. Its boiling point may vary depending on the attractive force between molecules. If the attractive force between molecules is large, the boiling point is also high; the melting point is related to the lattice arrangement and the strength of the intermolecular force. The density is related to the molecular mass and the degree of packing.
In terms of chemical properties, it has unique reactivity due to the presence of ester groups and pyrrole rings. The ester group can undergo hydrolysis reaction, and under acidic or basic conditions, it is hydrolyzed into corresponding acids and alcohols. In alkaline environments, hydrolysis is more complete, because the generated acid can react with the base, causing the equilibrium to shift to the right.
The pyrrole ring is aromatic and can undergo electrophilic substitution. The lone pair electrons on the nitrogen atom participate in the conjugation, which increases the electron cloud density on the ring, and the electrophilic substitution reaction activity is higher than that of benzene. The common check point for electrophilic substitution reactions is the α position of the pyrrole ring, because the electron cloud density of this position is relatively higher.
In addition, this compound can also participate in reactions such as with Grignard reagents, showing rich chemical changes, and has important uses in the field of organic synthesis.

Methyl 1-methylpyrrole-2-acetate, an organic compound, has important uses in many fields such as chemical industry and medicine.
In the chemical industry, it is often used as an intermediate in organic synthesis. Many different types of organic compounds can be derived through specific chemical reactions through structural modification and transformation. For example, when building complex organic molecular structures, as a key starting material, it participates in various bonding reactions with its unique chemical structure, laying the foundation for the synthesis of organic materials with specific functions and structures, such as the synthesis of certain high-performance polymer additives, which can optimize the properties of polymers, such as improving their stability and flexibility.
In the field of medicine, its role is also quite critical. First, it can be used as an intermediate for drug synthesis. In the synthesis path of many drug molecules, 1-methylpyrrole-2-methyl acetate can be connected to the key structural fragments of drug molecules through a series of chemical reactions to help build biologically active drug entities. For example, when developing some anti-tumor drugs, this is used as a raw material to synthesize drugs containing specific pharmacoactive groups through multi-step reactions to achieve targeted effects on tumor cells and inhibit growth. Second, it may have certain biological activity research value. Scientists can deeply explore its interaction with targets in vivo based on its structure, providing ideas and lead compound templates for the development of new drugs. By optimizing and modifying its structure, it is expected to obtain innovative drugs with better efficacy and fewer side effects.

To prepare methyl 1-methylpyrrole-2-acetate, the following approach can be started.
Take the pyrrole first, and introduce the methyl into the pyrrole at the first position in an appropriate method. In this step, a suitable methylating agent, such as iodomethane, can be selected. Under the catalysis of a base, the nitrogen atom of the pyrrole undergoes a methylation reaction to obtain 1-methylpyrrole.
Then, let 1-methylpyrrole be oxidized with acetic anhydride or acetyl chloride, and the acetyl group is introduced at the second position of pyrrole under the catalysis of Lewis acid such as anhydrous aluminum trichloride to obtain 1-methyl-2-acetyl pyrrole.
Then oxidize 1-methyl-2-acetyl pyrrole, and a suitable oxidizing agent such as Jones reagent can be used to oxidize the acetyl group to a carboxyl group to obtain 1-methylpyrrole-2-acetic acid.
Finally, the esterification reaction between 1-methylpyrrole-2-acetic acid and methanol under the catalysis of concentrated sulfuric acid under heating conditions can obtain the target product 1-methylpyrrole-2-acetic acid methyl ester. In this process, concentrated sulfuric acid not only acts as a catalyst, but also facilitates the balance of the esterification reaction to move towards the formation of esters. After the reaction is completed, the product can be purified through conventional post-treatment operations such as neutralization, liquid separation, and distillation. The whole synthesis route needs to pay attention to the control of the conditions of each step of the reaction and the avoidance of side reactions to improve the yield and purity of the product.

Methyl 1-methylpyrrole-2-acetate is an organic compound. When storing and transporting, pay attention to the following things:
First, storage temperature. This compound should be placed in a cool place away from direct sunlight to prevent it from decomposing or triggering chemical reactions due to excessive temperature. Due to excessive temperature, molecular activity can be enhanced, reaction probability can be increased, and material stability can be damaged.
Second, humidity effect. It is necessary to keep the storage environment dry. Moisture or moisture may react with the compound or cause it to hydrolyze, which affects the quality. If in a humid environment, the ester group may be hydrolyzed by water attack.
Third, sealed and stored. In order to prevent oxidation and other reactions in contact with the air, it should be ensured that the storage container is well sealed. Oxygen, carbon dioxide and other components in the air or interact with compounds to change their chemical properties.
Fourth, shock-proof transportation. Avoid violent vibration and collision during transportation. If the packaging is damaged and the compound leaks, it will not only be wasted but also endanger the safety of transportation personnel and the environment.
Fifth, isolated storage. Do not mix and transport with strong oxidants, strong acids, strong bases and other substances. Because of its active chemical properties, contact with these substances or cause violent reactions, such as contact with strong acids and strong bases, ester compounds may undergo hydrolysis, saponification and other reactions.
Sixth, follow the regulations. No matter whether it is storage or transportation, it is necessary to strictly follow relevant chemical management regulations and safety standards to ensure the safety of personnel and the environment from pollution.

I look at the market price range of "1 - METHYLPYRROLE - 2 - ACETIC ACID METHYL ESTER". This substance is an organic compound, which is often used in chemical synthesis, pharmaceutical research and development and many other fields. However, its market price fluctuates and is subject to a variety of reasons.
The first to bear the brunt is the different manufacturers, resulting in different costs and different prices. Well-known large factories have high prices due to their exquisite technology and excellent equipment, and high product purity; while emerging small factories compete for the market or use low prices as a policy.
Furthermore, the trend of market supply and demand is also the key. If there is a strong demand for this product in industries such as pharmaceutical research and development, and the supply is limited, the price will rise; on the contrary, if the supply exceeds the demand, the price will fall.
Once again, changes in the cost of raw materials also affect its price. If the price of raw materials required for its synthesis fluctuates, the price of the product will change accordingly.
As for the specific price range, it is difficult to determine. In common trading scenarios, the price per gram may be between tens of yuan and hundreds of yuan. If a large number of purchases are made, the unit price may decrease due to the scale effect. However, in order to obtain an accurate price, it is necessary to consult the relevant chemical product suppliers in detail, and obtain an exact quotation according to the current market conditions, purchase volume and other factors.