1-methyl-2-[(E)-2-nitroethenyl]-1H-pyrrole

1 - methyl - 2 - [ (E) -2 - nitroethenyl] -1H - pyrrole is an organic compound with unique chemical properties.
The physical properties of this compound, at room temperature and pressure or as a solid, however, also depend on the specific environment. The exact values of its melting point and boiling point depend on precise experimental determination. From the perspective of molecular structure, it contains pyrrole rings, and is connected to methyl at 1 position and (E) -2 - nitrovinyl at 2 positions. This structure gives it special chemical activity.
In terms of chemical activity, pyrrole rings have certain aromatic properties and can participate in electrophilic substitution reactions. Because the nitrogen atom has a lone pair of electrons, it can provide an electron cloud, which increases the density of the electron cloud on the ring and makes it vulnerable to attack by electrophilic reagents. The methyl group is the power supply group, which can further increase the density of the electron cloud on the ring and enhance the activity of electrophilic substitution reaction. (E) -2 -nitrovinyl moiety, the nitro group has strong electron-absorbing properties, or affects the distribution of molecular electron clouds, making this part vulnerable to attack by nucleophiles.
In the field of organic synthesis, this compound may serve as a key intermediate. For example, by electrophilic substitution, other functional groups are introduced into the pyrrole ring to construct organic molecules with more complex structures. Because it contains double bonds and nitro groups, or can participate in addition reactions, reduction reactions, etc., with appropriate reagents and reaction conditions, functional group transformation can be achieved to prepare compounds with specific properties.
This compound is rich in chemical properties and may have important application value in organic synthesis and related fields, but the actual properties and applications still need to be verified and explored by experiments.

The common synthesis methods of 1-methyl-2-[ (E) -2-nitrovinyl] -1H-pyrrole include the following.
One is to use pyrrole as the starting material. The methylation of the first position of pyrrole is first carried out. Appropriate methylation reagents, such as iodomethane and potassium carbonate in a suitable organic solvent, can be used for heating reaction, and methyl groups can be introduced at the first position of pyrrole. Then, the 2 - [ (E) -2 -nitrovinyl] part is introduced by Wittig reaction or Wittig-Horner reaction. Taking the Wittig reaction as an example, the nitro-containing phosphorus ylide reagent is first prepared, which can be prepared by the reaction of the corresponding halogenated nitroethane with triphenylphosphine, and then reacted with 1-methylpyrrole-2-formaldehyde under alkaline conditions to obtain the target product 1-methyl-2- [ (E) -2-nitrovinyl] -1H-pyrrole.
Second, 2-methylpyrrole can also be started. First, 2-methylpyrrole is reacted with a suitable nitrogenation reagent to introduce nitro at the ortho-position of the methyl group at the 2-position of the pyrrole ring to form a nitromethylpyrrole derivative. Then, through a suitable dehydration reaction, the nitromethyl group is converted into (E) -2 -nitrovinyl structure. This process requires the selection of appropriate dehydrating agents, such as p-toluenesulfonic acid, to react under suitable reaction conditions to obtain 1-methyl-2- [ (E) -2 -nitrovinyl] -1H -pyrrole.
Furthermore, a palladium-catalyzed cross-coupling reaction strategy can also be used. Using 1-methyl-2-halo pyrrole and boric acid or borate containing (E) -2-nitrovinyl as raw materials, in the presence of palladium catalyst, ligand and base, the reaction is heated in an organic solvent. Commonly used palladium catalysts such as tetra (triphenylphosphine) palladium (0), ligands such as three tert-butyl phosphine, etc., bases such as potassium carbonate, etc. Through this cross-coupling reaction, the carbon-carbon double bond structure of the target product can be efficiently constructed to achieve the synthesis of 1-methyl-2 - [ (E) -2 -nitrovinyl] -1H -pyrrole.

1 - methyl - 2 - [ (E) -2 - nitroethenyl] -1H - pyrrole, this is an organic compound, which has applications in various fields.
In the field of medicine, it may be a key intermediate for the synthesis of biologically active compounds. The molecular structure of the genome contains specific functional groups, such as nitro and pyrrole rings, which may endow the synthesized drugs with unique pharmacological properties. For example, the presence of nitro groups may affect the interaction between drugs and targets. Pyrrole rings also play an important role in the binding of drugs to biomacromolecules, or can be used to develop antibacterial, anti-inflammatory and other drugs.
In the field of materials science, this compound may be used to prepare functional materials. Due to its unique structure, specific groups can be introduced by chemical modification to give the material special electrical and optical properties. Such as polymerizing it through specific reactions, or preparing materials with photochromic properties, it has potential applications in optoelectronic devices such as sensors and display materials.
In the field of organic synthetic chemistry, it is often used as a synthetic building block. Due to the activity of double bonds and pyrrole rings in molecules, it can participate in a variety of organic reactions, such as nucleophilic addition, cyclization reactions, etc., providing an effective way to construct complex organic molecular structures. Chemists can use it as a starting material to synthesize organic compounds with different structures by manipulating reaction conditions and reagents, enriching the strategies and methods of organic synthesis.

1 - methyl - 2 - [ (E) - 2 - nitroethenyl] - 1H - pyrrole, Chinese name or 1 - methyl - 2 - [ (E) - 2 - nitroethenyl] - 1H - pyrrole, this is an organic compound. Its physical properties, let me talk about it in detail.
Looking at its appearance, under room temperature and pressure, it may be in a solid state. As for the color, it may be colorless to light yellow, but it is also disturbed by the amount of impurities. If there are few impurities, it will be light in color, and if there are many impurities, it will be dark in color. < Br >
When it comes to the melting and boiling point, the melting point is about [X] ° C, and the boiling point is about [X] ° C. The melting point is the critical temperature for a substance to change from a solid state to a liquid state; the boiling point is the critical temperature for a substance to change from a liquid state to a gaseous state. The melting and boiling point of this compound is determined by the intermolecular force. There is a van der Waals force between its molecules, and due to the presence of nitro ispolar groups, the molecular polarity is enhanced, and the intermolecular force also increases, so the melting and boiling point is relatively high.
In terms of solubility, it has a certain solubility in organic solvents such as dichloromethane and chloroform. Due to the principle of "similar miscibility", the compound has a certain polarity and can interact with polar organic solvents such as dichloromethane, and then dissolve. However, in water, the solubility is not good, because water is a strong polar solvent, and the polarity of this compound does not reach the degree of mutual solubility with water.
Above the density, it is about [X] g/cm ³, which is slightly heavier than water. The density is also the mass of the substance per unit volume. This value is related to the mass of the molecule and the degree of molecular accumulation. Its molecular mass is large, and the molecular accumulation is relatively tight, so the density is large.
In addition, the compound has a certain volatility. At room temperature, a small amount of molecules can escape from the solid or liquid surface into the air. The strength of volatility is inversely proportional to the magnitude of the intermolecular force. If the intermolecular force is small, the volatility is strong. The intermolecular force of this compound is not extremely strong, so it has a certain volatility.
The above physical properties are of key significance in the fields of chemical synthesis, separation and purification, and application research. During synthesis, the reaction temperature needs to be controlled according to its melting point; when separating and purifying, the appropriate solvent can be selected according to the solubility; in application research, the properties such as density and volatility also affect its use mode and scene.

1 - methyl - 2 - [ (E) -2 - nitroethenyl] -1H - pyrrole is one of the organic compounds. To view its market prospects, it needs to be viewed from multiple angles.
In the field of chemical industry, this compound may be a key intermediate for the synthesis of other complex organic molecules. The chemical industry is constantly seeking new raw materials and synthesis paths. If 1 - methyl - 2 - [ (E) -2 - nitroethenyl] -1H - pyrrole has unique reactivity and can lay the foundation for new synthesis methods, it may have a chance to emerge in the process of chemical synthesis. For example, based on it, novel drug molecular architectures can be developed, or materials with special properties can be prepared.
In the field of pharmaceutical research and development, organic compounds are often the source of new drug creation. If this compound is proven to have affinity or regulatory effects on specific disease targets through pharmacological studies, or even has potential biological activity, pharmaceutical companies will flock to it. For example, many small organic molecules in the past were initially unknown, but after in-depth research, they eventually became best-selling drugs. 1-methyl-2 - [ (E) -2 - nitroethenyl] -1H - pyrrole If it has such potential, the pharmaceutical market may open up doors for it.
In terms of materials science, with the growing demand for materials with special properties, this compound may find a place in the fields of optoelectronic materials and polymer materials due to its structural properties. If it can participate in the construction of material systems with special electrical and optical properties, it will gain attention and application in electronic equipment, display technology and other industries.
However, its market expansion also faces challenges. The complexity and cost of the synthesis process are key constraints. If the synthesis requires harsh conditions and expensive reagents, mass production and cost control will become difficult. And safety assessment is also indispensable. When the data on toxicity and environmental impact are unknown, the promotion and application are hindered.
In summary, 1 - methyl - 2 - [ (E) -2 - nitroethenyl] -1H - pyrrole market prospects, although there are opportunities, but also need to overcome various obstacles such as synthesis and safety, in order to shine in the market.