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What is the chemical structure of 1- (furan-2-ylmethyl) -1H-pyrrole?
1-% (imidazole-2-methyl) -1H-pyrazole, the chemical structure of this substance is relatively complex. I will describe it in detail for you.
In this structure, 1H-pyrazole is the basic framework. 1H-pyrazole is a five-membered heterocyclic compound containing two adjacent nitrogen atoms, with unique electron cloud distribution and chemical activity. The hydrogen atom on its ring can participate in various reactions under specific conditions.
And "1-% (imidazole-2-methyl) " is the substituent attached to the 1H-pyrazole No. 1 position. Imidazole is also a five-membered heterocycle, containing two non-adjacent nitrogen atoms, which has strong aromaticity and stability. The carbon atom at the imidazole 2 position is connected to a methylene (-CH 2O -), which is then connected to the 1H-pyrazole 1 position, forming the overall structure of 1-% (imidazole-2-methyl) -1H-pyrazole.
In this structure, the two heterocycles of pyrazole and imidazole are connected by methylene, so that the molecule has a special spatial configuration and electronic effect. The nitrogen atom in the heterocycle is rich in lone pair electrons, which can be used as an electron donor to participate in coordination reactions or form hydrogen bonds with other molecules. This structure gives the compound potential application value in medicinal chemistry, materials science and other fields. For example, in drug development, its unique structure may be compatible with specific biological targets and exhibit pharmacological activity; in the field of materials, or due to special electronic structure and spatial configuration, it presents unique optical and electrical properties.
What are the physical properties of 1- (furan-2-ylmethyl) -1H-pyrrole?
1- (imidazole-2-methyl) -1H-pyrazole, this is an organic compound. It has many physical properties.
Looking at its appearance, under room temperature and pressure, it is mostly white to light yellow crystalline powder, with fine texture. It can be seen in sunlight with tiny crystals shimmering like fine stars.
When it comes to melting point, it is about a specific temperature range. After precise experiments, its melting point value is relatively stable. This characteristic makes it show a specific law when heated. In the fields of chemical synthesis and material preparation, melting point is an important consideration index, which is related to the purification and molding of substances.
In terms of boiling point, under specific pressure conditions, there is a corresponding boiling point value. The boiling point characteristic affects its performance in distillation, separation and other processes, according to which it can be effectively separated from other substances based on the difference in boiling point.
Solubility is also a key property. In organic solvents, such as common ethanol and dichloromethane, the compound exhibits a certain solubility. In ethanol, with the increase of temperature, the solubility may change, which is of great significance for solution preparation and reaction system construction; in water, its solubility is relatively limited, which is related to the polarity of the groups in its molecular structure. The proportion and distribution of hydrophilic groups determine its solubility in the aqueous phase.
Density, measured by professional instruments, has a specific density value. Density, as a basic property of a substance, affects the state and stability of the mixture when stored, transported, and mixed with other substances.
In addition, the stability of this compound is also worthy of attention. Under normal environmental conditions, it has certain chemical stability, but under extreme conditions such as strong acids, strong bases, or specific high temperatures and light, the structure may change, triggering chemical reactions and generating new substances. This characteristic requires special attention when using and storing.
In what fields is 1- (furan-2-ylmethyl) -1H-pyrrole used?
1- (imidazole-2-methyl) -1H-pyrazole has important applications in many fields such as medicine, pesticides, and materials science.
In the field of medicine, it exhibits significant biological activity. Many studies have shown that compounds containing this structure have potential antibacterial effects and can inhibit the growth and reproduction of some bacteria, opening up new paths for the development of new antibacterial drugs. In the exploration of anti-tumor drugs, it has also emerged, interfering with the proliferation of tumor cells through specific mechanisms, and is expected to become a key structural unit for the development of high-efficiency and low-toxicity anti-tumor drugs. In addition, in the research and development of drugs for neurological diseases, it may regulate physiological processes such as the transmission of neurotransmitters, bringing new hope for the treatment of related diseases.
In the field of pesticides, 1- (imidazole-2-methyl) -1H-pyrazole-related derivatives have good insecticidal and bactericidal properties. For some common crop pests, such as aphids, mites, etc., pesticides containing this structure can precisely act on specific physiological targets of pests, kill pests efficiently, and pollute the environment relatively little, which is in line with the current trend of green pesticide development. At the same time, common crop pathogens, such as powdery mildew, rice blast bacteria, etc., also show significant inhibitory activity, helping to stabilize agricultural production and increase income.
In the field of materials science, this compound can be used as an important building block for the construction of new functional materials. Due to its unique molecular structure and electronic properties, it can participate in the molecular design and assembly process of materials. For example, in the field of fluorescent materials, the introduction of this structure can regulate the luminous properties of materials, and prepare fluorescent materials with specific luminous wavelengths and intensities, which have potential application value in sensors and display technologies. In polymer materials, it can be used as a crosslinking agent or functional monomer to improve the mechanical properties and thermal stability of materials, expanding the application range of polymer materials.
What are the synthesis methods of 1- (furan-2-ylmethyl) -1H-pyrrole?
The synthesis method of 1- (imidazole-2-methyl) -1H-pyrrole is an important topic in the field of organic synthetic chemistry. There are many synthesis methods, each with its own advantages, and varies according to different starting materials and reaction conditions.
First, the target structure is constructed by using a nitrogen-containing heterocyclic compound as the starting material through suitable reaction steps. For example, select a specific imidazole derivative, use an alkylation reaction, introduce methyl at the 2-position of imidazole, and then form a 1H-pyrrole structure through a cyclization reaction. In this process, the condition control of the alkylation reaction is very critical, and the precise selection of base, solvent and reaction temperature is required to improve the yield and selectivity of the reaction.
Second, a multi-step reaction strategy is adopted. The key intermediates are first prepared through a series of reactions, and then the intermediates undergo cyclization and condensation reactions to generate the target product. For example, starting from simple nitrogen and carbon-containing feedstocks, the molecular skeleton of 1- (imidazole-2-methyl) -1H-pyrrole is gradually constructed through nucleophilic substitution, oxidation, cyclization and other steps. Although this path is complicated, the molecular structure can be finely regulated to obtain high-purity products.
Furthermore, the synthesis method of transition metal catalysis has also attracted much attention. With the unique activity of transition metal catalysts, the formation of carbon-nitrogen bonds and carbon-carbon bonds is promoted, and the efficient synthesis of target compounds is achieved. For example, using transition metals such as palladium and copper as catalysts, under mild reaction conditions, catalytic substrates undergo coupling reactions, cyclization reactions, etc., to achieve the synthesis of 1- (imidazole-2-methyl) -1H-pyrrole. This method has mild reaction conditions, is environmentally friendly, and has a high yield, which has good application prospects.
There is also an idea of bionic synthesis. The synthesis of 1- (imidazole-2-methyl) -1H-pyrrole is achieved under milder conditions by using enzymes or catalysts to simulate the chemical reaction mechanism in living organisms. This method is green and environmentally friendly, with high selectivity, but it is currently limited by the source and stability of enzymes and has not been widely used in industrial production.
How stable is 1- (furan-2-ylmethyl) -1H-pyrrole?
The characterization of 1- (imidazole-2-methyl) -1H-pyrrole is based on multiple factors. In this compound, the characterization of imidazole-pyrrole phase is affected by molecular properties, molecular effects, and space resistance. For
molecules, imidazole is aromatic, and pyrrole is also aromatic. The aromatic phase of the pyrrole forms a larger co-ordination, which makes the distribution of the molecules of the whole molecule more average, and the energy is reduced, so the qualitative improvement is improved. The co-effect of the aromatic system can effectively disperse the charge and reduce the imbalance of molecular components. This is an important factor in determining the molecule.
The sub-effect is also affected. 2-Methyl is applied to the imidazole, and the methyl group is supplied to the imidazole group to increase the density of the imidazole group, and the common effect is reduced to the pyrrole group, so that the density distribution of the whole molecule can be changed. Donating the molecular group can increase the degree of some resistance in the molecule, improve its ability to resist externalized reaction, and increase the quality.
In terms of space resistance, the existence of 2-methyl is not significant, but it still affects the interaction of molecules to a certain extent. If there are other molecules in the surrounding environment close, the space of methyl groups will affect the interaction, which may cause the reaction of the molecule to be generated and maintain its own stability.
However, external components such as dissolution, dissolution, and chemical properties can also affect the characterization of 1- (imidazole-2-methyl) -1H-pyrrole. High temperature may increase the energy of the molecule, exceeding a certain limit, and the transformation of the molecule may be cracked, resulting in a decrease in the characterization of the molecule. Specific dissolution may form an interaction with the molecule, change the distribution of its molecules or break the original interaction of the molecule, and affect the characterization. In the reaction, if the oxidation or the original reaction is encountered, the molecule may be reacted, and the reaction will be changed and the characterization will be reduced.
Therefore, 1- (imidazole-2-methyl) -1H-pyrrole itself has a certain degree of certainty due to factors such as molecular and molecular effects, but the transformation of external components may still cause its qualitative effects.