1-BOC-Pyrrole-2-boronic acid, pinacol ester

1 + - + BOC + - + pyrrole-2-boronic acid pinacol ester, which has a wide range of uses. In the field of organic synthesis, it is often a key building block for the construction of complex organic molecules. It can participate in the Suzuki coupling reaction, which is an important means of building carbon-carbon bonds, and plays an important role in many aspects of medicinal chemistry and materials science.
In drug development, with the help of Suzuki coupling reaction, this compound can be used as a raw material to efficiently synthesize active molecules with diverse structures, laying the foundation for the creation of new drugs. For example, it can be coupled with halogenated aromatics to generate aromatic compounds containing pyrrole structures. Such compounds may have unique biological activities and can be used as potential drug precursors for in-depth research.
In the field of materials science, it can be introduced into the skeleton of polymer materials through related reactions. Due to its structural properties, or endowing materials with unique optoelectronic properties, such as being applied to organic Light Emitting Diode (OLED) materials to improve the luminous efficiency and stability of materials and enhance the display effect.
Or it can be used to prepare functional nanomaterials. Through rational design of reaction paths, the morphology and properties of materials can be adjusted to meet the needs of special functional materials in different fields. All these show that 1 + - + BOC + - + pyrrole-2-boronic acid pinacol esters are indispensable and important compounds in organic synthesis, drug development, materials science and other fields.

1 + - BOC-pyrrole-2-boronic acid pinacol ester, the physical properties of this substance are as follows. It is a white to off-white solid and is quite stable under normal conditions. Looking at its appearance, it is powder or crystalline, uniform and delicate.
Its melting point has a specific value, which is about a certain temperature range. This property is very critical in identification and purity testing, and can be used to determine whether its purity is up to standard. In terms of solubility, it has a certain solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide, but it has little solubility in water. This difference in solubility can be used in the synthesis and separation steps to achieve effective purification and purification.
Its density is relatively moderate. When chemical operation and storage, this factor should be considered, and the storage method and conditions should be reasonably arranged to avoid inconvenience or affect its chemical properties due to density differences. Due to its physical properties, it can be used as an important intermediate in many organic synthesis reactions, participating in the construction of various complex organic compounds, and occupying an important position in the research and production practice of organic chemistry.

The method of synthesizing 1 - (BOC) -pyrrole-2 -boronic acid pinacol ester can follow the following path.
First, pyrrole is used as the starting material. The nitrogen atom of pyrrole is first protected by BOC, and in this step, it can be reacted with di-tert-butyl dicarbonate (Boc -2 O) in the presence of a suitable base such as triethylamine. The base can assist in capturing the proton on pyrrole nitrogen, which prompts the smooth replacement of BOC groups to generate 1 - (BOC) -pyrrole. Subsequently, 1- (BOC) -pyrrole is borated. The commonly used boration reagent is the diphenylpyrrole-2-boronyl alcohol ester (B -2 pin -2), and a suitable metal catalyst, such as palladium catalyst, such as tetra (triphenylphosphine) palladium (Pd (PPh)), needs to be added. In a suitable organic solvent, such as toluene, the reaction is under heating conditions. The metal catalyst can activate the substrate and the boronizing reagent to successfully connect the boron atom to the No. 2 position of pyrrole, thereby obtaining 1- (BOC) -pyrrole-2-boronic acid pinacol ester.
Second, other suitable precursors can also be used. If there are pyrrole derivatives with suitable substituents that already have some of the desired structures, selective reactions can be carried out to treat other groups first, retaining the pyrrole ring structure, followed by BOC protection and boronation reactions. For example, if there are some easily convertible groups on the pyrrole ring, it can be converted into suitable intermediates first, then BOC protection, and finally boronation. This process requires careful selection of reaction conditions and reagents according to the specific substituent properties to ensure that the reaction proceeds along the desired path without affecting the pyrrole ring and other desired structures.

1 + - BOC-pyrrole-2-boronic acid pinacol ester has many things to pay attention to during storage. This substance should be placed in a cool, dry and well-ventilated place, and must not be exposed to high temperature or humidity. High temperature can easily cause its chemical properties to change, and humidity may cause reactions such as hydrolysis, which will damage its purity and quality.
Furthermore, it is necessary to strictly avoid contact with oxidants, acids, bases and other substances. Due to its chemical structure, such substances are prone to chemical reactions and cause product deterioration. When storing, it should be placed separately from the above items to prevent interaction.
When storing, also pay attention to the integrity of the packaging. If the package is damaged, the outside moisture, oxygen, etc. or intrusion will affect its stability. Therefore, it is necessary to check the package regularly. If there is any damage, appropriate measures should be taken immediately, such as changing the package.
In addition, the temperature and humidity of storage should be accurately controlled and recorded. Real-time monitoring can be done with the help of a thermometer to ensure that the environmental conditions are suitable. If conditions permit, storage equipment with temperature and humidity control function can be used to maintain a stable storage environment. In this way, the quality and performance of 1 + - BOC - pyrrole - 2 - boronic acid pinacol ester during storage can be guaranteed.

"Tiangong Kaiwu" is a scientific and technological masterpiece written by Song Yingxing in the Ming Dynasty, but there is no record of the market price of "1- (BOC-pyrrole-2-boronic acid, pinacol ester) ". This compound is a specific chemical in the field of organic synthesis, and its price is affected by many factors.
From the perspective of preparation, if the synthesis steps are complicated, many special reagents and catalysts are required, and the reaction conditions are harsh. If precise temperature, pressure control and inert gas protection are required, the cost will be high, and the price will also rise. The difficulty of obtaining raw materials is also critical. If raw materials are scarce or difficult to prepare, the overall cost will be pushed up.
The relationship between supply and demand in the market has a great impact. If the compound is in strong demand in pharmaceutical research and development, materials science and other fields, but the supply is limited, the price will rise; conversely, if the demand is low and the supply is sufficient, the price may stabilize or drop.
Quality and purity also affect the price. High-purity products require finer purification processes, consume more resources and costs, and the price is often higher than that of low-purity products.
Different suppliers have different pricing strategies. Well-known and reputable suppliers may have higher prices due to their advantages such as brand value, quality control and after-sales services; emerging or small suppliers may set lower prices in order to seize the market.
As far as the current market is concerned, it is difficult to determine the specific price due to the lack of exact data. However, you can consult chemical product suppliers, chemical reagent sales platforms, or inquire from industry insiders in relevant industry forums and professional communities to obtain more accurate price information.