thieno[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester

This is the chemical structure analysis of 3-aminothiopheno [2,3-b] pyridine-2-carboxylate ethyl ester. In its structure, thiopheno [2,3-b] pyridine is the core parent ring. The thiophene ring and the pyridine ring are fused in a specific way to form this unique cyclic structure. At the second position of the pyridine ring, there is a carboxyl-derived ethyl ester group, which is formed by esterification of carboxyl groups with ethanol, giving the molecule specific chemical activity and physical properties. The 3 position is connected to the amino group, which has nucleophilic properties and has a great influence on the reactivity and biological activity of the compound. Overall, the structure of the compound fuses different functional groups, and the interaction of each functional group determines its chemical behavior and potential applications. This structure may show unique value in the fields of organic synthesis, pharmaceutical chemistry, etc., because different functional groups can participate in a variety of chemical reactions, laying the foundation for the synthesis of complex compounds or the development of drugs with specific activities.

Thiopheno [2,3-b] pyridine-2-carboxylic acid, 3-amino-, ethyl ester, the physical properties of this substance are as follows:
Its appearance is usually white to off-white crystalline powder, with a fine and uniform texture. It exists stably at room temperature and pressure, is not easy to volatilize, and has no special odor. Melting point is one of the important physical constants for identifying the substance. Its melting point is in a specific temperature range. At this temperature, the substance changes from solid to liquid. This temperature range is of great significance to the determination of the purity of the substance. If the purity is high, the melting point range is relatively narrow and the fluctuation is small; if it contains impurities, the melting point will be reduced and the melting range will be widened.
In terms of solubility, it shows different solubility characteristics in some common organic solvents. In organic solvents such as ethanol and acetone, it has a certain solubility and can be partially or completely dissolved to form a homogeneous solution. This characteristic is widely used in organic synthesis and separation and purification processes. It can effectively separate the substance from the mixture by means of differences in solubility of different solvents. However, the solubility in water is poor, and it is basically insoluble or slightly soluble, which is related to the fact that there are few hydrophilic groups in the molecular structure of the substance and a large proportion of hydrophobic structures.
Density, as a material characteristic, reflects the mass per unit volume, and has a fixed value under specific conditions. It provides a reference for studying the distribution and behavior of the substance in different systems. For example, when mixed with other liquids, the stratification situation and mixing characteristics are judged according to the density difference.
The above are the common physical properties of thiopheno [2,3-b] pyridine-2-carboxylic acid, 3-amino-, ethyl ester, which are of great significance for in-depth understanding of its properties and applications in various chemical processes.

Thiopheno [2,3-b] pyridine-2-carboxylic acid, 3-amino-, ethyl ester This substance has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate to help create new drugs. Its unique structure is often favored by chemists when building complex active molecular structures. It can endow drug molecules with unique activities and characteristics, or can enhance the affinity and selectivity of drugs to specific targets, thereby enhancing drug efficacy and reducing side effects.
In the realm of organic synthesis, it is an important building block. Through various organic reactions, such as nucleophilic substitution, coupling reactions, etc., it can be connected to various functional groups or structural units to construct rich and diverse organic compounds, providing key raw materials for materials science, total synthesis of natural products and other fields.
In addition, in the field of biological activity research, its structure is similar to that of some active substances in organisms, or it has potential biological activities, such as anti-inflammatory, antibacterial, and anti-tumor. Scientists can conduct in-depth research based on this, explore its mechanism of action, and develop new bioactive molecules to contribute to human health. Therefore, thiopheno [2,3-b] pyridine-2-carboxylic acid, 3-amino-ethyl ester has important value and broad application prospects in many fields.

There are currently methods for the synthesis of 3-amino-thiopheno [2,3-b] pyridine-2-carboxylic acid ethyl ester, which are described in detail below.
First, thiopheno [2,3-b] pyridine-2-carboxylic acid is taken as the starting material and reacted with suitable reagents to introduce amino groups. This step is often carried out with ammonia or amino-containing compounds under suitable reaction conditions. For example, a catalyst can be added to a specific organic solvent, and the temperature and reaction time can be controlled to make the reaction occur smoothly to obtain 3-amino-thiopheno [2,3-b] pyridine-2-carboxylic acid.
Subsequently, the obtained 3-amino-thiopheno [2,3-b] pyridine-2-carboxylic acid is esterified with ethanol under acid catalysis. Commonly used acids such as sulfuric acid and p-toluenesulfonic acid are reacted under the condition of heating and refluxing, which prompts the esterification of carboxylic acid and ethanol to generate 3-amino-thiopheno [2,3-b] pyridine-2-carboxylic acid ethyl ester. After the reaction, the purified product can be obtained by conventional separation and purification methods such as extraction, distillation, recrystallization, etc.
Another way is to use suitable nitrogen-containing heterocyclic compounds and thiophene derivatives as raw materials to construct a thiopheno [2,3-b] pyridine skeleton through multi-step reaction, and at the same time introduce amino and carboxyl groups, and finally carry out esterification to obtain the target product. During the reaction process, it is necessary to precisely control the reaction conditions of each step to ensure the selectivity and yield of the reaction, so that 3-amino-thiopheno [2,3-b] pyridine-2-carboxylate can be efficiently synthesized. Ethyl ester.

I don't know the price range of this "thieno [2,3 - b] pyridine - 2 - carboxylic acid, 3 - amino -, ethyl ester" in the market. This is a rather professional chemical substance, and its price often varies due to many factors.
First, purity is crucial. If the purity is very high, almost perfect, and there is no impurity interference, the price will be high; if the purity is slightly lower, with some impurities, the price may drop.
Second, the supply channel also affects. If it is obtained from a stable and well-known supplier, the price may be fixed due to guaranteed quality; if it is from a small factory or a new source, or due to reputation pending, the price may be different.
Third, the market supply and demand trend is the key. If the demand for this product is strong, people compete to buy it, and the supply is limited, just like water in a dry time, the price will rise; if the demand is low and the supply is excessive, just like rain in a flood, the price will decline.
Fourth, the difficulty of preparation is related to the cost, which in turn affects the price. If the preparation process is complicated and requires exquisite skills and special raw materials, the cost will be high and the price will be high; if the preparation is relatively simple, the cost is controllable, and the price is close to the people.
To know the exact price range, you need to consult the chemical product trading platform, professional chemical suppliers, or the relevant chemical market survey.