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What is the chemical structure of Tert-Butyl 4- [ (Trifluoromethyl) Sulfonyloxy] -5,6-Dihydropyridine-1 (2H) -Carboxylate?
This compound is called tert-butyl 4- [ (trifluoromethyl) sulfonyloxy] -5,6-dihydropyridine-1 (2H) -carboxylate.
Looking at its name, it can be seen that this is an organic compound. "Tert-butyl" is a specific hydrocarbon structure, which is shaped like a hydrogen atom in butane is replaced by other groups to form a group with a specific spatial structure. It is often used as a protective group in organic synthesis or affects the spatial resistance of compounds.
"4- [ (trifluoromethyl) sulfonyloxy]", indicating that at the 4th position of the pyridine ring, there is a group of (trifluoromethyl) sulfonyloxy. ( Among trifluoromethyl) sulfonyloxy groups, trifluoromethyl has strong electron-absorbing properties, which has a great influence on the electron cloud distribution and chemical properties of compounds; sulfonyloxy groups endow compounds with certain reactivity, which is often the activity check point for reactions such as nucleophilic substitution.
"5,6-dihydropyridine-1 (2H) -formate", revealing the partial structure of the pyridine ring. The pyridine ring is hydrogenated at positions 5 and 6, 1 (2H) indicates a specific number and unsaturation, and the first position is connected with a formate group. This structural unit gives the compound a certain conjugate system and potential reactivity.
In the structure of this compound, the interaction of various groups determines its physical and chemical properties. It may have important application value in the fields of organic synthesis, medicinal chemistry, etc. It can be used as an intermediate for the synthesis of more complex organic compounds.
What are the main uses of Tert-Butyl 4- [ (Trifluoromethyl) Sulfonyloxy] -5,6-Dihydropyridine-1 (2H) -Carboxylate
Tert-butyl 4- [ (trifluoromethyl) sulfonyloxy] -5,6 -dihydropyridine-1 (2H) -formate, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate.
Looking at its structure, it has unique functional groups and can lead to a variety of chemical reactions. In the process of constructing complex pyridine compounds, it can add specific groups to the pyridine ring through specific reactions, such as nucleophilic substitution, thereby expanding the diversity of molecular structures and laying the foundation for the synthesis of other nitrogen-containing heterocyclic compounds.
In the field of medicinal chemistry, or can be used as a synthesis module for lead compounds. Since the pyridine structure is common in many drug molecules, and functional groups such as trifluoromethyl sulfonyloxy can adjust the physical and chemical properties of the molecule, such as lipophilicity and stability, it may help to develop new drugs with better pharmacological activity and pharmacokinetic properties.
In the field of materials science, through appropriate reactions, polymer systems may be introduced to endow materials with special properties. For example, the pyridine structure can participate in coordination, or make the material exhibit the ability to recognize specific ions; the introduction of trifluoromethyl may improve the chemical resistance and thermal stability of the material.
What is the synthesis method of Tert-Butyl 4- [ (Trifluoromethyl) Sulfonyloxy] -5,6-Dihydropyridine-1 (2H) -Carboxylate
The synthesis of tert-butyl 4- [ (trifluoromethyl) sulfonyloxy] -5,6 -dihydropyridine-1 (2H) -formate is a delicate chemical process. The starting point of its synthesis often requires the selection of suitable pyridine derivatives as raw materials. This raw material needs to have a specific structure in order to construct the basic structure of the target product in the subsequent reaction.
The first step, or the appropriate activation treatment of the pyridine derivative. The reactivity can be improved by introducing a specific substituent. The selection of this substituent requires precise consideration of the selectivity and yield of the reaction. For example, a nucleophilic substitution reaction can be used to connect a specific group to a specific position in the pyridine ring. < Br >
In the next step, under suitable reaction conditions, the activated pyridine derivative is reacted with a reagent containing trifluoromethyl sulfonyl group. This reaction requires strict control of the reaction temperature, time and the ratio of reactants. If the temperature is too high or too low, the reaction may deviate from the expected path, or reduce the yield, or form by-products. The control of time is also critical. If it is too short, the reaction will not be completed, and if it is too long, it will cause an overreaction. The precise allocation of the ratio of reactants can ensure that the reaction proceeds efficiently in the direction of generating the target product.
Furthermore, in the process of synthesizing tert-butyl 4- [ (trifluoromethyl) sulfonyloxy] -5,6 -dihydropyridine-1 (2H) -carboxylate, the use of protective groups is also an important link. Tert-butoxycarbonyl, as a common group for protecting amino groups, can be introduced and removed at appropriate stages to avoid unnecessary reactions of amino groups during the reaction process and ensure the selectivity of the reaction and the purity of the product.
Finally, after the reaction is completed, a series of separation and purification steps are required. Methods such as extraction and column chromatography can effectively remove impurities in the reaction system and obtain high-purity target products. Each step requires careful operation to successfully synthesize tert-butyl 4- [ (trifluoromethyl) sulfonyloxy] -5,6 -dihydropyridine-1 (2H) -formate.
What are the physical properties of Tert-Butyl 4- [ (Trifluoromethyl) Sulfonyloxy] -5,6-Dihydropyridine-1 (2H) -Carboxylate
Tert-butyl 4- [ (trifluoromethyl) sulfonyloxy] -5,6-dihydropyridine-1 (2H) -formate, the physical properties of this substance are as follows:
Its appearance is mostly white to off-white crystalline powder, which is caused by the arrangement of atoms and groups in the molecular structure, which forms a relatively regular crystal structure under conventional conditions. Under normal temperature and pressure, the properties are stable. This stability is due to the strength and spatial configuration of chemical bonds in the molecule, which makes the molecule less prone to chemical reactions. The melting point range of
is about [specific value]. The specific value of the melting point depends on the size of the intermolecular force. The steric resistance and electronic effect of the groups such as tert-butyl and trifluoromethyl sulfonyloxy in the molecule work together on the intermolecular interaction, and then determine the melting point.
In terms of solubility, it is slightly soluble in water. Although the molecule contains polar sulfonyloxy and formate groups, but there are non-polar tert-butyl and trifluoromethyl at the same time. The overall polarity is limited, and the interaction with water molecules is weak, so it is difficult to dissolve in water. The solubility is good in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF), etc. This is because these organic solvents can form interactions such as van der Waals forces and hydrogen bonds with the molecules of the substance, thereby promoting dissolution.
The density is about [specific value], and the density is determined by the relative molecular mass of the molecule and the degree of molecular packing compactness. The number and arrangement of atoms in the molecular structure of this substance give it a specific density value.
In addition, the substance has a certain degree of volatility, but the degree of volatility is low. In the conventional storage and use environment, the volatilization loss is relatively small, which is due to the fact that the intermolecular forces are sufficient to limit the escape of molecules from the liquid or solid surface.
In summary, the physical properties of tert-butyl 4- [ (trifluoromethyl) sulfonyloxy] -5,6 -dihydropyridine-1 (2H) -formate esters are determined by their unique molecular structures, which play a key role in their synthesis, storage, transportation, and application.
What is the market outlook for Tert-Butyl 4- [ (Trifluoromethyl) Sulfonyloxy] -5,6-Dihydropyridine-1 (2H) -Carboxylate?
Tert-Butyl 4 - [ (Trifluoromethyl) Sulfonyloxy] -5, 6 - Dihydropyridine - 1 (2H) -Carboxylate, that is, 4 - [ (trifluoromethyl) sulfonyloxy] -5, 6 - Dihydropyridine - 1 (2H) -tert-butyl carboxylate, this product has a specific position in the field of chemical and pharmaceutical research and development, and its market prospect is quite promising.
In the chemical industry, with the rapid development of the fine chemical industry, the demand for special structural organic compounds is increasing day by day. Due to its unique structure and chemical properties, this compound can be used as a key intermediate for the synthesis of many complex organic molecules. For example, in the synthesis process of new polymer materials, it can introduce special functional groups, thereby endowing the material with unique properties, such as better chemical stability and thermal stability. With the increasing demand for high-performance materials in the electronic information industry, the market for fine chemical products continues to expand, which brings broad market opportunities for 4- [ (trifluoromethyl) sulfonyloxy] -5,6 -dihydropyridine-1 (2H) -tert-butyl carboxylate.
In the field of pharmaceutical research and development, fluorinated organic compounds often exhibit unique biological activities due to the special properties of fluorine atoms, such as high electronegativity and small atomic radius. The trifluoromethyl sulfonyloxy part of this compound may have a key impact on its interaction with biological targets, and it is very likely to become an important starting material for the development of new drugs. At present, innovative drug research and development has attracted much attention, and there is a strong demand for compounds with novel structures and potential biological activities. Therefore, from the perspective of pharmaceutical research and development, 4- [ (trifluoromethyl) sulfonyloxy] -5,6-dihydropyridine-1 (2H) -tert-butyl carboxylate is expected to emerge on the stage of new drug development with its unique structure, and the market prospect is promising.
However, its market development also faces some challenges. On the one hand, the synthesis of this compound may involve more complicated processes and high costs, which may hinder large-scale production and limit its market supply scale. On the other hand, although its potential application prospects are broad, the specific application effect still needs a lot of experiments and studies to verify, and the market acceptance of it will take some time. Overall, the market prospect of 4- [ (trifluoromethyl) sulfonyloxy] -5,6-dihydropyridine-1 (2H) -tert-butyl carboxylate is promising, but it needs to overcome the difficulties of synthesis and market recognition in order to fully unleash its market potential.