tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylate

This substance tert - butyl 4- (4,4,5,5 - tetramethyl - 1,3,2 - dioxaborolan - 2 - yl) -3,6 - dihydro - 2H - pyridine - 1 - carboxylate, in Chinese or can be called 4- (4,4,5,5 - tetramethyl - 1,3,2 - dioxoboran - 2 - yl) -3,6 - dihydro - 2H - pyridine - 1 - tert-butyl carboxylate. Its main uses are mostly involved in the field of organic synthesis.
In the process of organic synthesis, this compound is often used as a key intermediate. The delicate nature of organic synthesis, such as the construction of delicate pavilions, all intermediates are indispensable masonry. The borate groups contained in this substance have unique reactivity. In the palladium-catalyzed cross-coupling reaction, it is like a smart dancer who can dance elegantly with halogenated aromatics or halogenated olefins to form carbon-carbon bonds. Through such reactions, complex structures can be cleverly spliced, paving the way for the creation of new organic molecules.
Furthermore, in the field of pharmaceutical chemistry, organic synthesis is a sharp edge for the creation of new drugs. This compound may be the cornerstone for the synthesis of specific biologically active molecules. By modifying and derivatization of its structure, it is expected to give birth to new drug lead compounds. After pharmacological screening and optimization, it may become a good medicine for the world and contribute to human health and well-being. In the process of drug development such as anti-cancer and anti-infection, such intermediates may silently play a key role behind the scenes, helping researchers explore the cure for diseases.

To prepare tert - butyl 4- (4,4,5,5 - tetramethyl - 1,3,2 - dioxaborolan - 2 - yl) -3,6 - dihydro - 2H - pyridine - 1 - carboxylate, the method of synthesis, common people have the following.
One, can be started by the corresponding pyridine derivative. First, the pyridine ring is modified, and a group capable of reacting with borate esters is introduced at a suitable check point. For example, using pyridine with a suitable substituent as a raw material, through halogenation, the pyridine ring is connected to a halogen atom at a specific position. Subsequently, under the catalysis of palladium, the boration reaction is carried out with diphenoxanal borate. This process requires careful selection of reaction conditions. The type of palladium catalyst, the collocation of ligands, the choice and dosage of bases will all affect the reaction. Commonly used palladium catalysts such as Pd (PPh), the base can be selected from potassium carbonate, etc., in a suitable organic solvent, such as dioxane, react at a certain temperature to promote the substitution of the halogen with the borate ester group to form the borate part of the target product. At the same time, another amino group protected by tert-butoxycarbonyl (Boc) needs to be introduced on the pyridine ring, which can be achieved by reacting with reagents such as Boc-acid anhydride under appropriate conditions, and the final target product is obtained. < Br >
Second, starting from the nitrogen-containing heterocyclic construction strategy. The structure of the dihydropyridine ring can be constructed first, and the functional groups that can be further reacted can be reserved at suitable positions. For example, the dihydropyridine ring is constructed by the condensation reaction of the enamide and the carbonyl compound under the catalysis of acid. Subsequently, the borate group is introduced through a boration reaction similar to the above, and then the tert-butoxycarbonyl protective amino group is introduced to complete the synthesis of the target product. This route requires fine regulation of the reaction conditions at each step to ensure the selectivity of the cyclization reaction and the accuracy of subsequent functional group introduction.
Third, stepwise splicing from simple raw materials can also be considered. For example, the compound containing amino group and double bond is used as the starting material, first reacts with suitable acylation reagents, introduces carboxyl group related fragments, and then constructs dihydropyridine ring through cyclization reaction. After that, boration reaction and tert-butoxycarbonylation reaction, borate ester group and tert-butoxycarbonyl are introduced in sequence to obtain the target product. Although this path is simple in raw materials, it has many steps, and requires high reaction conditions and purification of intermediates. Each step needs to be carefully controlled to improve yield and purity.

This is called tert-butyl 4- (4,4,5,5-tetramethyl-1,3,2-dioxoboronyl-2-yl) -3,6-dihydro-2H-pyridine-1-carboxylate. Its physical and chemical properties are unique, let me tell you in detail.
The appearance of this substance is often white to light yellow crystalline powder. Looking at its solubility, in organic solvents, such as common dichloromethane, N, N-dimethylformamide, etc., it has a good solubility performance. This characteristic is due to the interaction between organic groups in its molecular structure and solvent molecules. However, in water, its solubility is poor, because the hydrophobic part of the molecule accounts for a large proportion.
The melting point is finely determined to be within a specific temperature range, which reflects the lattice energy and intermolecular forces. At this temperature, the lattice is destroyed and the solid state is converted to a liquid state.
In terms of boiling point, due to the molecular mass and intermolecular forces, it is necessary to obtain enough energy at a higher temperature to overcome the attractive forces between molecules before it can change from a liquid state to a gaseous state.
In terms of chemical properties, the boron ester groups in the molecule have unique reactivity. It can participate in many boron-related chemical reactions, such as Suzuki coupling reaction. In this reaction, the boron ester group can be coupled with halogenated aromatics or halogenated olefins under the action of suitable catalysts and bases to form new carbon-carbon bonds, which is an important means to construct complex molecular structures in organic synthesis. The tert-butyl and pyridine ring parts also affect the overall electron cloud distribution and reactivity of the molecule. Pyridine ring has a certain alkalinity and can react with acids to form corresponding salts. Tert-butyl has a significant effect on the selectivity of molecular reaction check points due to its large steric resistance. In some reactions, it can protect specific groups from premature reaction.

I see what you are inquiring about, but it is "tert - butyl 4- (4,4,5,5 - tetramethyl - 1,3,2 - dioxaborolan - 2 - yl) - 3,6 - dihydro - 2H - pyridine - 1 - carboxylate" in the market price range. However, the price of this product is difficult to sum up.
Because the market is impermanent, its price often changes for a variety of reasons. The first one to bear the brunt is the purity of the product. If the purity is extremely high and there are few impurities, the price will be high; if the purity is slightly inferior, the price may be slightly reduced.
Furthermore, the trend of supply and demand also affects its price. If there are many people seeking this product, but there are few suppliers, the price will rise; conversely, if the supply exceeds the demand, the price will drop.
Again, the difficulty of preparation and the cost of raw materials are also the key. Preparation is difficult, the price of raw materials is high, and the price of finished products is high; if preparation is easy and raw materials are cheap, the price may be close to the people.
As for the exact price range in the market, it is difficult to determine. To know the details, you can consult chemical product suppliers, traders, or visit relevant chemical trading platforms to get a more accurate price. The price also changes at any time, and it is necessary to pay attention to market dynamics in real time in order to grasp the trend of its price.

Tert - butyl 4- (4,4,5,5 - tetramethyl - 1,3,2 - dioxaborolan - 2 - yl) - 3,6 - dihydro - 2H - pyridine - 1 - carboxylate is an organic compound. To store it properly, appropriate conditions should be set according to its characteristics.
This product is quite sensitive to air and moisture, so the first thing is to store it in a dry and inert gas protected environment. For example, it can be placed in a closed container filled with nitrogen or argon to prevent the intrusion of air and moisture. Due to moisture or adverse reactions such as hydrolysis, it will deteriorate and damage its quality and utility.
Temperature is also critical. Usually it should be stored at a low temperature, preferably about -20 ° C to 0 ° C. Low temperature can slow down its chemical reaction rate and maintain its chemical stability. High temperature may cause its decomposition, polymerization and other reactions to accelerate, reducing its shelf life.
The storage place should be kept away from heat and fire sources. Because of its flammability, it may be dangerous in case of heat or open flame.
In addition, storage containers should also be carefully selected. Containers made of glass or specific plastic materials should be used. Such materials are chemically stable and not easy to react with the compound. And the container should be well sealed to prevent leakage and external factors. < Br >
Proper storage of this compound is of great significance in maintaining the stability of its quality and chemical properties. According to the above conditions, it can be maintained in good condition for a certain period of time for scientific research, production and other purposes.