tert-Butyl 3a-benzyl-2-methyl-3-oxo-3a,4,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-5(3H)-carboxylate

This compound is named tert-butyl 3a-benzyl-2-methyl-3-oxo-3a, 4,6,7-tetrahydro-2H-pyrazolo [4,3-c] pyridine-5 (3H) -carboxylic acid ester. Its main uses are commonly found in the fields of organic synthesis and medicinal chemistry.
In organic synthesis, such compounds containing nitrogen heterocyclic structures can be used as key intermediates. Due to its unique molecular structure, it can be connected with other organic molecules by means of a variety of chemical reactions, such as nucleophilic substitution, electrophilic addition, etc., to construct more complex organic compounds, laying the foundation for the synthesis of new functional materials and natural product analogs.
In the field of pharmaceutical chemistry, compounds containing pyrazolopyridine structures often exhibit diverse biological activities. Studies have shown that such structures may have potential pharmacological activities, such as anti-tumor, anti-inflammatory, and antibacterial. Researchers can modify and optimize the structure of this compound, design and synthesize a series of derivatives, and search for lead compounds with high activity and low toxicity through biological activity screening, providing an important direction and material basis for the development of new drugs.

To prepare tert - Butyl 3a - benzyl - 2 - methyl - 3 - oxo - 3a, 4,6,7 - tetrahydro - 2H - pyrazolo [4,3 - c] pyridine - 5 (3H) -carboxylate, the following method can be followed.
First, a compound containing pyrazole and pyridine structures is used as the starting material. The starting material is first benzylated, and a suitable benzylation reagent, such as benzyl halide, can be selected to introduce benzyl into a specific position in the presence of a base. The choice of base is crucial. Inorganic bases such as potassium carbonate and sodium carbonate, or organic bases such as triethylamine, can depend on the reaction conditions and the characteristics of the substrate.
Then, the resulting intermediate is methylated. Commonly used methylating reagents are iodomethane, dimethyl sulfate, etc. This reaction also needs to be carried out under the catalysis of an appropriate base to promote the successful insertion of methyl groups.
Then, the reaction of constructing a carbonyl group can be carried out. It can be achieved by means of oxidation reaction or condensation with a carbonyl-containing reagent. For example, a suitable oxidizing agent is selected to oxidize a specific group to a carbonyl group; or a carbonyl group is introduced by reacting with an acylating agent. < Br >
is then cyclized within the molecule to construct the fused ring structure of pyrazolopyridine. This step requires the selection of suitable reaction conditions, such as temperature and solvent. Suitable solvents such as toluene, dichloromethane, etc., the temperature depends on the specific reaction mechanism and substrate activity.
During the synthesis process, each step of the reaction needs to be carefully monitored. The reaction process can be tracked by thin-layer chromatography (TLC) to see if the reaction is complete and whether the substrate is exhausted. After the reaction is completed, the separation and purification of the product is also crucial. Column chromatography can be used to select an appropriate silica gel column and elute with layers of eluents of different polarities to obtain a pure target product. The whole synthesis process requires rigorous operation and attention to the control of various reaction conditions, so that tert-Butyl 3a-benzyl-2-methyl-3-oxo-3a, 4,6,7-tetrahydro-2H-pyrazolo [4,3-c] pyridine-5 (3H) -carboxylate can be successfully prepared.

Alas! This is an organic compound, tert-butyl 3a-benzyl-2-methyl-3-oxo-3a, 4,6,7-tetrahydro-2H-pyrazolo [4,3-c] pyridine-5 (3H) -formate. To understand its physical and chemical properties, let me tell you one by one.
Its physical properties are at room temperature, or in a solid state. Because there are many cyclic and heteroatoms in its structure, the intermolecular force is strong. As for the color, it may be colorless to yellowish, because there is no strong chromogenic group in the structure. Its melting point, or in a certain temperature range, covers the binding force between molecules. When heated to a certain temperature, the lattice begins to break and turn into a liquid state.
As for chemical properties, there are ester groups in the structure, which are active groups. In contact with water or under acid-base catalysis, hydrolysis can occur. When catalyzed by acid, the proton first binds to the carbonyl oxygen of the ester group to enhance the positive electricity of the carbonyl carbon, and the hydrophilic attack forms carboxylic acids and alcohols; when catalyzed by alkali, the hydroxide nucleophilic attack carbonyl carbon, and the ester bond breaks to form carboxylate and alcohol. And its structure contains the ring system of pyrazolopyridine, which has certain aromaticity and can participate in electrophilic substitution reactions, such as halogenation and nitrification. The electron cloud density distribution on the ring is different, and the specific position is vulnerable to electrophilic attack. In addition, there are methyl and benzyl groups in the molecule, although they are relatively stable, they can also participate in the reaction under strong oxidation or free radical initiation conditions, such as benzyl hydrogen can be replaced by halogen atoms. This is its approximate physical and chemical properties.

I don't know what the market price of tert - Butyl + 3a - benzyl - 2 - methyl - 3 - oxo - 3a, 4,6,7 - tetrahydro - 2H - pyrazolo [4,3 - c] pyridine - 5 (3H) -carboxylate is. This compound is very complex, or it is a special chemical reagent, and its price varies according to quality, purity, source and purchase quantity.
If you ask for it in ordinary pharmacies or chemical shops, the price may be different. For high quality and high purity, the price will be high; if you buy it in large quantities, there may be discounts. However, I have not personally seen its market sale, and there are no examples of past transactions to refer to. It is difficult to determine the range of its price.
And market conditions are fickle, and the price of materials changes with supply and demand and current situations. Or the price is low at that time, and the price is high at this time; or the price is low in A, and the price in B is high. Therefore, if you want to know the exact price, you need to consult a merchant specializing in chemical reagents, or check the relevant chemical product trading platform to get a near-real price.

Fu tert - Butyl 3a - benzyl - 2 - methyl - 3 - oxo - 3a, 4,6,7 - tetrahydro - 2H - pyrazolo [4,3 - c] pyridine - 5 (3H) -carboxylate is one of the organic compounds. The related derivatives of this compound are often used in the field of organic synthesis in various reaction processes.
In the process of organic synthesis, it is used as a starting material, or it can be used for nucleophilic substitution reactions to introduce other functional groups at specific positions. For example, on nitrogen atoms or carbon atoms, due to a certain electron cloud density, it can interact with nucleophilic reagents to derive new compounds containing different substituents.
Or in the reduction reaction, the intracellular carbonyl group may be reduced to derive the corresponding alcohol derivative. This reduction process may use reducing agents such as metal hydrides to change the structure and properties of the compound.
Furthermore, in the cyclization reaction, the compound may further undergo intramolecular cyclization due to its own specific structure to form derivatives such as fused rings or bridging rings, which may be achieved by suitable catalysts and reaction conditions.
In the field of biological activity exploration, such derivatives may exhibit different biological activities. For example, some derivatives may have inhibitory activity on specific enzymes, or combine with receptors in organisms to affect physiological processes. These are all possible scenarios for related derivatives of this compound. In organic chemistry and related fields, in-depth investigation of them may reveal more valuable chemical and biological phenomena.