tert-butyl 2H,4H,5H,6H,7H-pyrazolo[4,3-b]pyridine-4-carboxylate

This is an investigation into the chemical structure of tert-butyl-2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylic acid esters. In its structure, tert-butyl (-C (CH < unk >) < unk >) is a specific group attached to a specific parent nucleus structure. The parent nucleus is pyrazolo [4,3-b] pyridine, which is formed by fusing the pyrazole ring with the pyridine ring in a specific way. The pyrazole ring contains two adjacent nitrogen atoms, and the pyridine ring is a six-membered nitrogen-containing aromatic ring. The two fuse to form unique spatial and electronic properties. 4-Carboxylic acid esters indicate that there is a carboxylic acid ester group (-COOR) attached to the pyridine ring at position 4, where R is tert-butyl (-C (CH < unk >) < unk >). This structure endows the compound with specific physical and chemical properties. In the field of organic synthesis and medicinal chemistry, due to its unique structure, or specific biological activity and reaction characteristics, it may have potential applications in the development of new drugs and organic functional materials.

Tert-butyl 2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylic acid esters, which are widely used. In the field of medicinal chemistry, it is often a key intermediate, enabling the creation of new drugs. The structure of Geinpyrazolo-pyridine can exhibit a variety of biological activities in the design of drug molecules, such as anti-tumor, anti-viral, anti-inflammatory, etc. Tert-butyl 2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylic acid esters are chemically modified and optimized, and new drugs with excellent efficacy and minor side effects may be developed.
In the field of organic synthesis, it is an important building block for the construction of complex organic molecules. With its specific structure and reactivity, it can participate in many organic reactions, such as nucleophilic substitution, cyclization, etc., to build organic compounds with special structures and functions, and lay the foundation for materials science, total synthesis of natural products and other fields.
also has potential application value in pesticide research and development. After rational design and modification, high-efficiency, low-toxicity, and environmentally friendly pesticide varieties may be developed, which have good control effects on pests, pathogens, etc., and contribute to sustainable agricultural development.
In short, tert-butyl 2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylic acid esters have important uses in many fields such as medicine, organic synthesis, and pesticides. With the deepening of scientific research, its application prospects may be broader.

To prepare tert-butyl 2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylic acid esters, the following method can be followed.
First, a suitable pyridine derivative is used as the starting material, and this derivative needs to contain functional groups that can be converted into a pyrazolo [4,3-b] pyridine structure through a specific reaction. This pyridine derivative is co-reacted with a hydrazine-containing reagent under suitable reaction conditions. This reaction condition should include suitable solvents, such as polar organic solvents, such as N, N-dimethylformamide (DMF), to assist in the dissolution of the reactants and facilitate the reaction. At the same time, it is necessary to control the reaction temperature and time. Generally, the reaction can be carried out for several hours under moderate heating conditions to promote the condensation reaction between the pyridine derivative and the hydrazine reagent to initially construct the structure of the pyrazole ring.
After the initial formation of the pyrazole ring, tert-butoxycarbonyl (Boc) is introduced to construct the structure of the tert-butyl ester. Tert-butyl dicarbonate (Boc -2 O) is selected as the donor of tert-butoxycarbonyl and the reaction is carried out in the presence of an organic base. Commonly used organic bases such as triethylamine can help neutralize the acidic substances produced by the reaction and promote the positive reaction. This reaction at room temperature or slightly above room temperature, after several hours, the tert-butoxycarbonyl can be successfully connected to the position of pyrazolo [4,3-b] pyridine-4-carboxylic acid, and the final tert-butyl 2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylic acid ester is obtained.
After the reaction is completed, suitable separation and purification methods are required, such as column chromatography, silica gel column, and a suitable eluent system, such as petroleum ether and ethyl acetate mixed in a certain proportion of eluents, to separate and purify the target product from the reaction mixture to obtain pure tert-butyl 2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylate.

Tert-butyl 2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylic acid ester, this is an organic compound. Its physical properties are quite important, and it is related to many chemical and practical application scenarios.
First, let's talk about the appearance. It is usually a white to light yellow crystalline powder, just like the fine snow that falls in the early winter, or the light yellow frost at the end of autumn. It is delicate and distinct in color. This appearance feature can help chemists preliminarily determine its purity and state.
In addition, the melting point is about 100-120 ° C, just like cooking at the right temperature. In this temperature range, the compound will change from solid to liquid state. The accurate determination of the melting point is of great significance for the identification and purity evaluation of compounds, just like an accurate scale.
As for solubility, it is slightly soluble in water, but easily soluble in common organic solvents, such as dichloromethane, ethanol, etc., just like the adaptability of fish in water and different media. This solubility characteristic determines the solvent selection in various chemical reactions and preparation processes.
In addition, density is also one of its important physical properties, about 1.2 - 1.3 g/³ cm, just like the internal compactness of the substance, which is indispensable for the calculation of the relationship between mass and volume in the reaction system.
The physical properties of tert-butyl 2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylic acid esters play a key role in organic synthesis, drug development and other fields. By grasping these properties, chemists can more accurately control related chemical reactions and processes.

Today there are tert-butyl 2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylate, and its market prospects are worth exploring. This compound may have extraordinary potential in the field of pharmaceutical chemistry. Looking at the past medical research and development, new nitrogen-containing heterocyclic structures are often the key cornerstones for the creation of special drugs. Tert-butyl 2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylate contains a unique pyrazolopyridine structure, which may be precisely compatible with specific biological targets, and has emerged in the development of anti-tumor, anti-inflammatory and neuroprotective drugs.
In the field of materials science, it may contribute to the synthesis of new functional materials. For example, in the field of organic optoelectronic materials, nitrogen-containing heterocyclic compounds can optimize the photoelectric properties of materials due to their unique electronic structure. the particularity of the structure of tert-butyl 2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylate may endow materials with novel optical and electrical properties, providing new opportunities for the development of cutting-edge materials such as organic Light Emitting Diodes and solar cells.
However, there are challenges in the marketing of its activities. The complexity of the synthesis process or the high production cost limit its large-scale production and application. And there are many competing compounds in the same category. To win a place in the market, it is necessary to demonstrate advantages in performance and cost-effectiveness. But overall, if we can break through the synthesis bottleneck and optimize the production process, tert-butyl 2H, 4H, 5H, 6H, 7H-pyrazolo [4,3-b] pyridine-4-carboxylate is expected to open up a broad market space and stimulate new changes in the industry.