tert-butyl 2-bromo-6,7-dihydro-4H-thiazolo[5,4-c]pyridine-5-carboxylate

This is about the chemical structure of "tert - butyl 2 - bromo - 6,7 - dihydro - 4H - thiazolo [5,4 - c] pyridine - 5 - carboxylate". This compound is composed of a specific atomic combination and connection method. "Tert - butyl" is a tert-butyl group, whose structure is a carbon atom connected to three methyl groups, namely - C (CH < unk >) < unk >, which is commonly used as a substituent in organic chemistry. "2 - bromo" indicates that at a specific position in the main structure, that is, the number 2, there is a bromine atom as a substituent, and the bromine atom is a halogen element, which is chemically active. " 6,7 - dihydro - 4H - thiazolo [5,4 - c] pyridine "part, the thiazolo-pyridine ring system is formed by fusing the thiazolo ring with the pyridine ring, and the 6 and 7 positions are in the form of dihydrogen, which means that the carbon atoms at these two positions are connected to the hydrogen atom to form an unsaturated bond state." 5 - carboxylate "indicates the presence of a carboxylate group at position 5, which forms an ester bond with a carboxyl group and an alcohol, namely - COO - R, where R is tert-butyl. In summary, the structure of this compound is composed of tert-butyl, bromine atom, dihydrothiazolopyridine ring and 5-position carboxylic acid ester group, and each part is connected and combined to form a unique chemical structure, which endows the compound with specific chemical and physical properties. It has important research and application value in the fields of organic synthesis, medicinal chemistry, etc.

Tert-butyl 2-bromo-6,7-dihydro-4H-thiazolo [5,4-c] pyridine-5-carboxylic acid ester has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the creation of new drugs. Its unique chemical structure can interact with specific biological targets, or can be used to develop drugs with antibacterial, anti-inflammatory, anti-tumor and other effects. For example, in the development of antibacterial drugs, by modifying the structure of the compound, it can precisely act on specific metabolic pathways or key proteins of bacteria to inhibit bacterial growth and reproduction.
In the field of organic synthesis, this compound is an important starting material for the construction of complex organic molecules. With its bromine atom, thiazolopyridine structure and carboxylic acid ester group, other functional groups can be introduced through various chemical reactions, such as nucleophilic substitution, coupling reaction, etc., to expand the complexity and diversity of molecular structures, so as to construct organic materials with unique properties and functions.
In the field of materials science, after specific chemical modifications, materials may be endowed with unique photoelectric properties. For example, the introduction of conjugate structure improves its charge transport ability, which can be used to prepare optoelectronic devices such as Light Organic Emitting Diodes and solar cells to improve device performance and efficiency.
In summary, tert-butyl 2-bromo-6,7-dihydro-4H-thiazolo [5,4-c] pyridine-5-carboxylate has important application value in the fields of medicine, organic synthesis and materials science, providing a key material foundation and innovation possibility for the development of related fields.

To prepare tert-butyl 2-bromo-6,7-dihydro-4H-thiazolo [5,4-c] pyridine-5-carboxylic acid ester, the synthesis method can be carried out according to the following steps.
First, a suitable pyridine derivative is used as the starting material. This pyridine derivative needs to have a functional group that can be reacted and converted into the pyridine part of the target structure. In a suitable reaction vessel, add the pyridine derivative and create a suitable reaction environment, such as selecting an appropriate reaction solvent, which needs to be able to dissolve the reactants without interfering with the reaction process. Common organic solvents such as dichloromethane, N, N-dimethylformamide, etc. can be considered.
Then, introduce a reagent capable of constructing a thiazole ring. This reagent should have the activity of reacting with a specific functional group of the pyridine derivative to form a thiazolopyridine structure. During the reaction process, the reaction temperature and time must be precisely controlled. If the temperature is too high or too low, the reaction may be biased towards side reactions or the reaction may be too slow. In general, you can try to start the reaction near room temperature first. If the reaction is too slow, it will be moderately heated; if the side reactions increase, it will be appropriately cooled.
After the thiazolopyridine structure is initially formed, suitable brominating reagents can be selected for the introduction of 2-bromine in the target product. Common brominating reagents such as N-bromosuccinimide (NBS). When adding brominating reagents, pay attention to the addition method and rate. You can add them dropwise slowly to make the reaction proceed smoothly and reduce the occurrence of side reactions.
As for the introduction of tert-butyl ester groups, esterification reagents containing tert-butyl groups can be selected. This reagent reacts with the corresponding functional groups in the reaction system to obtain the structure of tert-butyl ester. After the reaction is completed, the product is often mixed with impurities and needs to be separated and purified. Column chromatography can be used to separate the product and impurities according to the difference in the partition coefficient between the stationary phase and the mobile phase. Or use the recrystallization method to select a suitable solvent to dissolve the product and recrystallize it to obtain pure tert-butyl 2-bromo-6,7-dihydro-4H-thiazolo [5,4-c] pyridine-5-carboxylate. During the whole synthesis process, each step of the reaction needs to be carefully monitored and regulated to achieve the ideal synthesis effect.

Tert-butyl 2-bromo-6,7-dihydro-4H-thiazolo [5,4-c] pyridine-5-carboxylate is an organic compound with unique physical properties. Its properties are mostly solid, due to intermolecular forces and structures. Melting point is a key indicator to consider its purity and stability, but the exact melting point varies depending on the preparation method and impurity content, and is roughly within a certain temperature range. Boiling point is also an important physical property, reflecting the volatility of the compound. A higher boiling point indicates that its volatility is low at room temperature and pressure.
The solubility of this compound is closely related to molecular polarity. Due to the structure containing polar groups and non-polar moieties, the solubility in organic solvents varies. In polar organic solvents such as dimethyl sulfoxide (DMSO) and N, N-dimethylformamide (DMF), it has good solubility due to polar interaction; in non-polar organic solvents such as n-hexane, the solubility is poor, because the non-polar moiety is difficult to interact with non-polar solvent molecules.
Density is also one of the physical properties. It characterizes the mass of a unit volume of a compound and is closely related to molecular accumulation. Accurate density determination requires experimental equipment, which is affected by temperature and pressure. It is usually measured under standard conditions as a basis for compound identification and quality control.
In terms of appearance, pure tert-butyl 2-bromo-6,7-dihydro-4H-thiazolo [5,4-c] pyridine-5-carboxylate or white to light yellow solid, color or due to the presence of impurities, so the appearance observation can preliminarily judge its purity.
The physical properties of this compound are of great significance in organic synthesis, drug development and other fields. For example, knowledge of melting point and boiling point helps to separate and purify compounds, solubility information guides the selection of reaction solvents, and appearance and density are indispensable for quality control and product identification.

Wen Jun inquired about the market prospect of "tert - butyl 2 - bromo - 6,7 - dihydro - 4H - thiazolo [5,4 - c] pyridine - 5 - carboxylate". This substance is a key intermediate in organic synthesis and has great potential in the field of pharmaceutical and pesticide research and development.
Looking at the field of medicine, the demand for new drug creation has increased in recent years. Many pharmaceutical companies are making every effort to explore novel active compounds to overcome difficult diseases. Due to its unique chemical structure, this intermediate can be derived from a variety of molecules with biological activity, or can be used to develop anti-tumor, anti-viral and other drugs. According to the research and development process of new drugs in the past, similar structural intermediates have attracted more attention, and there are many successful research and development cases. For example, a new anti-cancer drug uses similar intermediates in its key synthesis steps, and the market response after listing is quite good, and the sales volume is considerable. From this perspective, in the frontier exploration of pharmaceutical research and development, this intermediate is expected to gain more favor, and the market demand may increase with the development process of new drugs.
As for pesticides, people's demand for high-efficiency, low-toxicity, and environmentally friendly pesticides is increasing. This intermediate may provide the possibility for the creation of new pesticides, and help to develop pesticides and fungicides with unique mechanisms of action. Looking back at the development of pesticides, new structural intermediates often open up a new era of pesticide creation. For example, a new type of fungicide is synthesized based on a specific intermediate. Once launched, it occupies a considerable market share because of its high efficiency and environmental protection characteristics. Therefore, in the field of pesticides, this intermediate also has broad prospects and is expected to follow the development trend of green pesticides and become an important raw material for innovative research and development of pesticide companies.
However, its market prospects are also restricted by many factors. The complexity of the synthesis process is related to the production cost. If the process is cumbersome, the cost remains high, or its large-scale application is limited. And the research and development cycle of new drugs and new pesticides is long, the risk is quite high, and the research and development is frustrated or failed, which will But overall, driven by innovation in the fields of medicine and pesticides, the market prospects for "tert - butyl 2 - bromo - 6,7 - dihydro - 4H - thiazolo [5,4 - c] pyridine - 5 - carboxylate" are quite promising, and over time, it may emerge in the chemical intermediates market.